Role of free radicals and antioxidant status in childhood nephrotic syndrome

Ghodake, SR; Suryakar, Adinath N.; Ankush, R. D.; Katkam, R. V.; Shaikh, Kayyum; Katta, Ashok

doi:10.4103/0971-4065.78062

Cited by 17 publications

(14 citation statements)

References 27 publications

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“…MDA is an important end-product generated by lipid peroxidation and has been used to demonstrate increased oxidative stress during chronic kidney disease [ 45 ]. In our study, rats in ADR-treated group presented with high level of plasma MDA which indicated an increased lipid peroxide concentration [ 46 , 47 ]. ZWT decreased plasma MDA and inhibited the lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Protection Effect of Zhen‐Wu‐Tang on Adriamycin‐Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage

Liang

Lai

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Zhen-wu-tang (ZWT), a well-known formula in China, is widely used to treat chronic kidney diseases. However, very little information on ZWT's mechanism of action is currently available. In this study, we investigated the possible protective role and underlying mechanism of ZWT on nephrotic syndrome (NS) induced by Adriamycin (intravenous injection, 6.0 mg/kg) in rats using biochemical and histopathological approaches. ZWT decreased urine protein excretion and the serum levels of total cholesterol, triglycerides, blood urea nitrogen, and creatinine significantly in diseased rats. A decrease in plasma levels of total protein and albumin was also recorded in nephropathic rats. Pathological results show an improved pathological state and recovering glomerular structure in ZWT treatment groups. ZWT decreased renal IL-8 level but increased renal IL-4 level. In addition, rats subjected to ZWT exhibited less IgG deposition in glomerulus compared with model group. RT-PCR results showed that ZWT decreased the mRNA expression of NF-κB p65 and increased the mRNA expression of IκB. Furthermore, ZWT reduced the level of MDA and increased SOD activity. These results demonstrated that ZWT ameliorated Adriamycin-induced NS in rats possibly by inhibiting Adriamycin-induced inflammation damage, enhancing body's antioxidant capacity, thereby protecting glomerulus from injury.

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Section: Discussionmentioning

confidence: 99%

Protection Effect of Zhen‐Wu‐Tang on Adriamycin‐Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage

Liang

Lai

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Oxidative stress plays an important role in the pathogenesis of several diseases, including renal diseases, and may be associated with the pathogenesis of proteinuria in NS patients [4]. Reactive oxygen species (ROS) play an important role in the development of progressive renal damage [5].…”

Section: Introductionmentioning

confidence: 99%

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Yazılıtaş

Öztek-Celebi

Erel

et al. 2019

Nephron

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Background: There is a growing body of evidence showing that there is an association between oxidative damage and kidney injury in patients with nephrotic syndrome (NS). Dynamic thiol/disulphide homeostasis (DTDH) is an important antioxidant system. The aim of this study was to determine if DTDH could be used as a biomarker of antioxidant status in pediatric NS patients using a novel automated method. Methods: The study included 39 patients with NS and 40 healthy controls. The DTDH level was measured using a calorimetric and automated method developed by Erel and Neselioglu. In the NS group, DTDH was measured during first-attack episode, relapse, and remission. Results: The native thiol, total thiol, and disulphide levels were significantly lower, the native thiol/total thiol ratio was significantly lower, and the disulphide/native thiol and disulphide/total thiol ratios were significantly higher in the NS patients during relapse and first-attack episode than during remission and in the controls. In addition, the native thiol and total thiol levels, and the native thiol/total thiol ratio were significantly lower, and the disulphide/native thiol and disulphide/total thiol ratios were significantly higher in the NS group during remission than those in the control group. Conclusions: The present findings show that DTDH shifted toward disulphide formation in the NS patients, even during remission. A clearer understanding of the mechanism of this disruption to homeostasis in NS patients might lead to the development of novel therapeutic strategies.

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“…To date, several studies [9][10][11][12][13][14][15][16] have showed the alterations of these parameters in the INS subjects. However, the relative small number of participants limited the statistical power, and some of the results were in conflict.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis

Mao¹,

Zhang²,

Huang³

2014

Renal Failure

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It is well documented that oxidative stress is involved in the pathogenesis of idiopathic nephrotic syndrome (INS). Malondialdehyde (MDA) is a measurement of lipid oxidation; vitamin C and E are important components of antioxidants. However, the association between MDA, vitamin C or E levels and INS remains elusive. A meta-analysis was performed to investigate the alteration of serum levels of MDA, vitamin C and E in INS compared with controls. Eight studies were included in our meta-analysis according to predefined criteria. Active INS patients demonstrated significantly higher level of serum MDA (SMD: 2.13, 95% CI: 1.511 to 2.749, p510 ) and similar level of serum vitamin E compared with those in controls. No significant publication bias was observed. In conclusion, the disorder of MDA and vitamin C persists in the remission stage of INS. It seems that the serum levels of vitamin C and E is associated with the responsiveness of INS to steroids. However, more studies should be performed in the future.

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Role of free radicals and antioxidant status in childhood nephrotic syndrome

Cited by 17 publications

References 27 publications

Protection Effect of Zhen‐Wu‐Tang on Adriamycin‐Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage

Protection Effect of Zhen‐Wu‐Tang on Adriamycin‐Induced Nephrotic Syndrome via Inhibiting Oxidative Lesions and Inflammation Damage

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis

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