Role of Gastric Motility in Development of Stress-Induced Gastric Lesions of Rats

Yano, Shingo; Akahane, Masuo; Harada, Masatoshi

doi:10.1254/jjp.28.607

Cited by 95 publications

(25 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric ulcers can be induced in experimental animals and humans by physical or psychological stress (Takagi and Okabe, 1968;Grossman, 1981). The main factors in the gastric lesion formation include: increase of acid secretion (Kitagawa et al, 1979;Menguy, 1969;Brodie et al, 1962) and increase of gastric motility (Garrick et al, 1986;Yano et al, 1978;Watanabe, 1966), decrease of gastric mucosal blood flow (Hase and Moss, 1973;Guth, 1972;Menguy, 1969;Guth PH, Kozbur, 1968) and decrease of alkaline secretion (Takeuchi et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Ulcerogenic Activities of Chantaleela Recipe

Sireeratawong¹,

Khonsung²,

Piyabhan³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Chantaleela recipe is indicated for relieving fever in Thai traditional folk medicine. In the present study, Chantaleela recipe was investigated for anti-inflammatory, analgesic, antipyretic and anti-ulcerogenic activities. In preliminary investigation Chantaleela recipe was found to exert an inhibitory activity on the acute phase of inflammation as seen in ethyl phenylpropiolate-induced ear edema as well as in carrageenan-induced hind paw edema in rats. The results suggest that the anti-inflammatory activity of Chantaleela recipe may be due to an inhibition via cyclooxygenase pathway. In the analgesic test, Chantaleela recipe showed a significant analgesic activity in both the early and late phases of formalin test, but exerted the most pronounced effect in the late phase. The analgesic activity of Chantaleela recipe may act via mechanism at peripheral and partly central nervous system. In antipyretic test, Chantaleela recipe significantly decreased rectal temperature of brewer's yeast-induced hyperthermia rats, probably by inhibiting synthesis and/or release of prostaglandin E 2 in the hypothalamus. Therefore, the key mechanism of anti-inflammatory, analgesic, and antipyretic activity of the Chantaleela recipe likely involves the inhibition of the synthesis and/or release of inflammatory or pain mediators, especially prostaglandins. The oral administration of the Chantaleela recipe reduced ulcer formation in acute gastric ulcer models (EtOH/HCl-, indomethacin-, and stress-induced gastric lesions). In contrast, this recipe did not reduce the secretory rate, total acidity, and increase pH in rat stomach. These results indicated that Chantaleela seem to possess anti-ulcerogenic effect. This activity may be due to the increase of gastric mucosal resistance or potentiation of defensive factors and/or the decrease of aggressive factors but did not associate the anti-secretory activity. Moreover, the high oral doses treated did not cause acute toxicity in rats and the long term oral administration did not produce gastric and ileum lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Ulcerogenic Activities of Chantaleela Recipe

Sireeratawong¹,

Khonsung²,

Piyabhan³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

show abstract

“…On the other hand, pirenzepine did not exhibit such a marked effect against ethanol-induced PD reduction. The role of gastric motor activity in the pathogenesis of gastric lesions has been recently suggested (11,(33)(34)(35). For example, hypermotility might be a major factor in the genesis of gastric lesions induced by a necrotizing agent such as absolute ethanol (11,33,34), because there is a relationship between the grade of ethanol-induced gastric lesions and the increase of gastric motility.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Profile of Gastric Mucosal Protection by Marmin and Nobiletin from a Traditional Herbal Medicine, Aurantii Fructus Immaturus

Takase¹,

Yamamoto²,

Hirano³

et al. 1994

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

ABSTRACT-We studied the effects of marmin and nobiletin on the experimental acute gastric lesions, gastric transmucosal potential difference (PD) and gastric motor activity in rats and the contractions of isolated guinea pig ileum. Oral administration of marmin and nobiletin inhibited both the appearance of ethanol-induced gastric hemorrhagic lesions dose-dependently in a dose range of 10-50 mg/kg, with ED50 values for marmin and nobiletin being 17.2 and 8.0 mg/kg, respectively. However, marmin and nobiletin had minimal effects on aspirin-induced gastric lesions at a dose of 50 mg/kg, respectively. Marmin and nobiletin had no significant influence on the basal PD. Intragastrical administration of marmin and nobiletin at a dose of 25 mg/kg significantly prevented the PD reduction induced by ethanol. Both marmin and nobiletin given intragastrically at 25 mg/kg significantly inhibited gastric motor activity measured as intraluminal pressure recordings. Marmin and nobiletin exhibited concentration-dependent relaxations of contractions induced by acetylcholine, transmural electrical stimulation and histamine in isolated guinea pig ileum, respectively. These findings suggest that the anti-ulcer effects of marmin and nobiletin are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine.

show abstract

“…Hypercontraction, an increase in gastric contraction, is a major pathogenic mechanism of ulcers induced by necrotizing agents 22) and stress. 23,24) a-LA signiˆcantly delayed gastric emptying in a dose-dependent manner, which suggested that a-LA inhibited gastric contraction. This delay of gastric emptying may be related to the increase of gastric ‰uid volume and gastric mucus volume.…”

Section: )mentioning

confidence: 95%

“…33) Delay of gastric emptying [19][20][21]34) and inhibition of gastric contraction 22,23) have been shown to contribute to gastroprotection. Hypercontraction, an increase in gastric contraction, is a major pathogenic mechanism of ulcers induced by necrotizing agents 22) and stress.…”

Section: )mentioning

confidence: 99%

“…[11][12][13] In addition to activation of PG synthesis, defense mechanisms of the gastric mucosa include stimulation of mucus 11,14) and bicarbonate secretion, 11,15,16) increase in gastric ‰uid volume, 17,18) and inhibition of gastric motility (emptying and contraction). [19][20][21][22][23][24] Under the hypothesis that a-LA aŠects these defense mechanisms, and strengthens gastric mucosa before exposure to damaging factors, we investigated the eŠects of a-LA on PGE2 content in gastric tissue, gastric mucin content, gastric luminal pH, gastric ‰uid volume, and gastric emptying in naive rats. We also examined the correlation between PG synthesis and the eŠects of a-LA on these defense mechanisms.…”

mentioning

confidence: 99%

See 1 more Smart Citation