Role of IL-2 and Helper T-Lymphocytes in Limiting Periapical Pathosis

Correlation Between Platelet-derived Growth Factor B Chain and Bone Resorption in Rat Periapical Lesions

“…These findings are in agreement with the concept that accumulation of inflammatory cells represents a protective host response aimed at eradicating the invading microorganisms and preventing the host from direct bacterial invasion of the bone surrounding the tooth apex (21,22). It has been reported that lymphocytes and their byproducts play an important role in limiting the development of periapical lesion (23). We found that the lymphocytes were the predominant PDGF-B-positive cell.…”

The Expression of Macrophage and Neutrophil Elastases in Rat Periradicular Lesions

“…Periradicular lesions were induced as described previously (27,28). In brief, all animals were anesthetized, and the pulpal tissues in the left and right mandibular first molars were exposed so that perforation of the furcation would be avoided.…”

“…The area of the lesion was the periodontal ligament between the root apex and alveolar bone in the mesial root. The cells reactive with antimacrophage and antineutrophil elastases were counted in an area 0.6 mm square of the periapical portion surrounding the root apex of the mesial root, and the number of antigen-positive cells per unit area (cells/mm 2 ) was calculated (28).…”

Expression of a Novel PDGF Isoform, PDGF-C, in Experimental Periapical Lesions

“…In addition, lymphocytes were the predominant cell type; this is in agreement with previous findings (15), and the lymphocytes were the predominant PDGF-C-positive cell. It has also been reported that lymphocytes and their byproducts play an important function in limiting the development of periapical lesion (31). All these points indicate that PDGF-C might limit the development of periapical lesion during the chronic phase.…”