Role of intestinal surfactant-like particles as a potential reservoir of uropathogenic Escherichia coli

Mahmood, Akhtar; Engle, Michael J.; Hultgren, Scott J.; Goetz, G.S.; Dodson, Karen W.; Alpers, David H.

doi:10.1016/s0304-4165(00)00095-7

Cited by 15 publications

(10 citation statements)

References 50 publications

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“…For instance, the periplasmic complex of FaeG and FaeE is able to agglutinate erythrocytes [Mol et al, 2001] and is recognised by monoclonal antibodies directed against conformational epitopes of F4 fimbriae [Bakker et al, 1991a]. This observation is in agreement with other fimbrial systems of which chaperone-adhesin complexes bind to their receptor [Kuehn et al, 1991;Mahmood et al, 2000]. However, expression of most fimbrial subunits also needs the periplasmic disulfide isomerase DsbA that catalyses disulfidebound formation [Hung and Hultgren, 1998;Jacob-Dubuisson et al, 1994a], but FaeG does not have cysteine residues [Klemm, 1981].…”

Section: Chaperone-subunit Complexes Are Folded Native-like and Prevementioning

confidence: 65%

F4 Fimbriae Expressed by Porcine Enterotoxigenic <i>Escherichia coli</i>, an Example of an Eccentric Fimbrial System?

Verdonck

Cox²,

Goddeeris³

2004

Microb Physiol

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An overwhelming number of infectious diseases in both humans and animals are initiated by bacterial adhesion to carbohydrate structures on a mucosal surface. Most bacterial pathogens mediate this adhesion by fimbriae or pili which contain an adhesive lectin subunit. The importance of fimbriae as virulence factors led to research elucidating the regulation of fimbrial expression and their molecular assembly process. This review provides an overview of the current knowledge of induction, expression and assembly of F4 (K88) fimbriae and discusses its unique as well as its identical characteristics compared to other intensively studied fimbriae or pili expressed by Escherichia coli.

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Section: Chaperone-subunit Complexes Are Folded Native-like and Prevementioning

confidence: 65%

F4 Fimbriae Expressed by Porcine Enterotoxigenic <i>Escherichia coli</i>, an Example of an Eccentric Fimbrial System?

Verdonck

Cox²,

Goddeeris³

2004

Microb Physiol

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“…One possible reason for this modulation could be that SLP prevents the interaction between the pathogen and the epithelial layer. Involvement of SLP in this kind of immune response can be speculated in the light of a similar study, where adhesion of uropathogenic E. coli is mediated at the tips of the pilli by the papG adhesion in presence of SLP (Mahmood et al. 2000).…”

Section: Discussionmentioning

confidence: 92%

Influence of Intestinal Surfactant Like Particles on Differential Activation of Secondary Signaling Molecules During Salmonella Typhimurium Infection

Sofi

Bhatnagar

Sapra

et al. 2010

Journal of Food Safety

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Interaction between the enteric pathogen Salmonella typhimurium and the luminal surface of the intestine provoke an acute inflammatory response mediated in part by various inflammatory molecules. Surfactant‐like particles (SLP) are known to cover the surface of the intestinal epithelium, act as lubricants and/or as a vehicle to deliver digestive enzymes to the luminal fluid. Recently we have shown that SLP plays an important protective role during microbial insult. The data suggested that SLP‐induced diet prevents the damage of intestinal villi caused by S. typhimurium infection. The present study was designed to assess the role of SLP on secondary signaling molecules during S. typhimurium infection. The Peyer's patch, intraepithelial and lamina propria mononuclear cells were analyzed under various conditions for secondary signaling molecules, including calcium, inositol triphosphate and protein kinase C. SLP‐induced diet along with infection showed significant variation in these secondary signaling molecules, particularly in Peyer's patches, as compared to infection group alone. In addition, the cells isolated from the infected group upon incubation in vitro with SLP also showed a considerable variation of these molecules. These results suggested an important influence of SLP on secondary signaling molecules and, in turn, could be important in overall immune modulation during infection. PRACTICAL APPLICATIONS Salmonella are known to cause disease in humans, animals and birds worldwide. Over 1.4 million cases of salmonellosis (gastroenteritis) per year occur in the U.S.A. and other industrialized countries. Countries with poor sanitation have a much higher incidence of salmonellosis. The disruption of epithelial barrier integrity by Salmonella has pathological consequences. Intestinal epithelium secretes surfactant‐like particles (SLP); these particles have the ability to cover the surface of the cell in the intestinal lumen. They are known to have ability in binding of uropathogenic Escherichia coli and in protecting the disruption of intestinal villi. The present study provides further evidence for its role in regulating secondary signaling molecules and overall immune response. SLP induced by dietary fat enhanced the resistance to intestinal infections, as it possibly decreases the colonization and translocation of S. typhimurium. The SLP and microbe interaction may thus represent a delicate balance between symbiosis and pathogenesis.

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“…Indeed, supportive experimental data exist (Adlerberth et al, 1995;Herı´as et al, 1995Herı´as et al, , 1997Mahmood et al, 2000;Wold et al, 1988). This hypothesis provides a more plausible mechanism for the evolution of these traits than does the associated enhanced pathogenicity, since the ability to cause selflimited or even fatal disease provides no obvious evolutionary advantage to E. coli.…”

Section: Virulence Versus Colonization Factorsmentioning

confidence: 84%

Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli

Johnson

Russo

2005

International Journal of Medical Microbiology

226

209

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Role of intestinal surfactant-like particles as a potential reservoir of uropathogenic Escherichia coli

Cited by 15 publications

References 50 publications

F4 Fimbriae Expressed by Porcine Enterotoxigenic <i>Escherichia coli</i>, an Example of an Eccentric Fimbrial System?

F4 Fimbriae Expressed by Porcine Enterotoxigenic <i>Escherichia coli</i>, an Example of an Eccentric Fimbrial System?

Influence of Intestinal Surfactant Like Particles on Differential Activation of Secondary Signaling Molecules During Salmonella Typhimurium Infection

Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli

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