Role of &lt;i&gt;Bifidobacterium bifidum&lt;/i&gt; and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis.

Al‐Okbi, Sahar Y.; Mohamed, Doha A.; Donya, Souria M.; Khalek, Ameen Abdel

doi:10.3989/gya.089810

Cited by 6 publications

(6 citation statements)

References 57 publications

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“…Other study demonstrated the similar reduction of the viable cells related to the inflammatory effect and proliferation of pathogenic strains [23]. An increase in the metabolic activity could determine a secondary synthesis of other compounds with antimicrobial effects.…”

Section: Resultsmentioning

confidence: 64%

Probiotic Strains Influence on Infant Microbiota in the In Vitro Colonic Fermentation Model GIS1

et al. 2015

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The main goal of our study was to evaluate the effect of the individual administration of five lyophilized lactic acid bacteria strains (Lactobacillus fermentum 428ST, Lactobacillus rhamnosus E4.2, Lactobacillus plantarum FCA3, Lactobacillus sp. 34.1, Weissella paramesenteroides FT1a) against the in vitro simulated microbiota of the human colon using the GIS1 system. The influence on the metabolic activity was also assessed by quantitative determination of proteins and polysaccharides at each segment of human colon. The obtained results indicated that the lactic acid bacteria L. rhamnosus E4.2 and W. paramesenteroides FTa1 had better efficiency in synthesising exopolysaccharides and also a better probiotic potential and therefore could be recommended for use in probiotics products or food industry.

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Section: Resultsmentioning

confidence: 64%

Probiotic Strains Influence on Infant Microbiota in the In Vitro Colonic Fermentation Model GIS1

et al. 2015

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“…The anticancer effect of tocopherols could mainly belong to γ-and δ-tocopherols because they can scavenge reactive oxygen and nitrogen species in addition to their antiangiogenic effects and their ability to inhibit nuclear factor-kappa B pathway (39). Total phenolic compounds were present as 3.97 and 2.57 g gallic acid equivalent/100 g in NI and NII, respectively while β-carotene was 0.53 and 33.95 mg/100 g (13). In the present study NI contained higher content of flavonoids compared to NII which could reflect the flavonoids content of green tea compared to broccoli while the flavonols of NII were higher than that of NI.…”

Section: Discussionmentioning

confidence: 99%

“…Plant extractions were carried out as reported previously (13). The dried powder of tomato and carrot were placed separately in a continuous extraction apparatus (soxhlet) and subjected to extraction using acetone for extraction of carotenoids including lycopenes.…”

Section: Preparation Of Plant Extractsmentioning

confidence: 99%

“…Nutraceutical II (NII) was prepared from crude ethanol extract of broccoli, hazelnuts oil and acetone extract of carrot as 1:1:1 (w/w/w). The nutraceuticals were prepared as described previously (13).…”

Section: Preparation Of Nutraceuticals (Extracts' Mixtures)mentioning

confidence: 99%

“…Carrots, tomatoes, broccoli, green tea, hazelnuts and wheat germ are reported as rich sources of antioxidant and anti-inflammatory bioactive constituents (11,12). In previous studies belonged to the present research team; nutraceuticals prepared from a mixture of ethanol extract of green tea, wheat germ oil and acetone extract of tomato and another mixture of ethanol extract of broccoli, hazelnuts oil and acetone extract of carrot were shown to possess anti-inflammatory effect in adjuvant arthritis as well as in vitro antioxidant activity and inhibiting effect on cell line liver carcinoma (HEPG2) (13,14). So, it is of interest to investigate the in-vivo protective effect of such nutraceuticals towards initiation of malignancy during exposure to carcinogenic agent.…”

Section: Introductionmentioning

confidence: 99%

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Amelioration of oxidative stress, inflammation and liver function by nutraceuticals in rat model of hepatic cancer initiation induced by N-nitrosodiethylamine

Al‐Okbi

Mohamed

Elbakry

2021

J Herbmed Pharmacol

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Introduction: Nutraceuticals might serve as protective agent against liver cancer induced by pro-cancerous chemicals that initiate high oxidative stress, inflammation and affect DNA integrity. The aim of the present research was to study the prevention of hepatocellular carcinoma initiation induced by N-nitrosodiethylamine (NDEA) through treatment by nutraceuticals. Methods: Two nutraceuticals were prepared; the first (NI) was a mixture of different extracts of green tea, wheat germ and tomato, the second one (NII) was composed of extracts mixture of broccoli, hazelnuts and carrot. Total flavonoids and flavonols were determined in the nutraceuticals. Four groups of rats were run; the first served as control normal, the other three groups were treated by intraperitoneal injection of NDEA, one of these groups was designated as control NDEA, the other two groups (test groups) were treated daily with oral doses of NI and NII, respectively. The experiment continued for 8 weeks. Plasma transaminases, alkaline phosphatase and catalase activities, total protein, albumin, malondialdehyde (MDA) and tumor necrosis factor-α (TNF-α) along with liver MDA level and catalase activity were assessed. Results: NI showed higher flavonoids and lower flavonols than NII (P < 0.05). High oxidative stress and inflammation biomarkers, liver dysfunction, reduced plasma albumin and total protein were demonstrated in control NDEA compared to control normal (P < 0.05). Test groups showed significant improvement in all parameters (P < 0.05) compared to NDEA control. NI was superior in improving plasma transaminases and catalase activities, MDA and TNF-α levels and liver catalase activity compared to NII (P < 0.05). Conclusion: Both NI and NII might prevent liver cancer initiation during exposure to carcinogenic agents, NI being superior to NII.

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Application of liquisolid technology for promoting the renoprotective efficacy of walnut extracts in chronic renal failure rat model

Al‐Okbi

Mohamed

Hamed

et al. 2018

Drug Development and Industrial Pharmacy

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Chronic renal failure (CRF) is among the major health problems that could lead to increased morbidity and mortality among population. 'Nutraceuticals' is an emerging field for natural agents from plant foods that could reduce the progression of such disease. Many newly developed drugs are having bioavailability problems owing to their water insolubility. Liquisolid technique is one of the promising technological approaches to increase solubility and hence, drug absorption. The aim of the present research is to prepare and evaluate the renoprotective effect of the walnut extracts liquisolid formulations in CRF rat model. Saturation solubility study claimed PEG 400 and Tween 20 as good solubilizers for walnut extracts, thus chosen for preparation. The angle of slide was determined for the carrier; microcrystalline cellulose and coating material; silicon dioxide and liquid load factor was evaluated. Eight liquisolid systems were prepared employing 25% and 50% of liquid medication. Their flow and compressibility parameters showed good properties. Dissolution study was more in favor of formulations prepared using PEG 400. Of these, formulation F8 comprising carrier/coat ratio (10:1) and 50% liquid medication, showing superior dissolution properties was selected to perform stability and in-vivo evaluations. Two CRF induced rat groups received F8 at two oral doses (50 and 100 mg/kg). Biochemical and nutritional parameters were compared with both normal and CRF control rats. Results showed improvement of renal function, oxidative stress, antioxidant and inflammatory biomarkers as well as increased appetite and body weight gain on administration of both doses of walnut liquisolid formulation, F8.

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Role of <i>Bifidobacterium bifidum</i> and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis.

Cited by 6 publications

References 57 publications

Probiotic Strains Influence on Infant Microbiota in the In Vitro Colonic Fermentation Model GIS1

Probiotic Strains Influence on Infant Microbiota in the In Vitro Colonic Fermentation Model GIS1

Amelioration of oxidative stress, inflammation and liver function by nutraceuticals in rat model of hepatic cancer initiation induced by N-nitrosodiethylamine

Application of liquisolid technology for promoting the renoprotective efficacy of walnut extracts in chronic renal failure rat model

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