Role of Marginal Zone B Lymphocytes in Invariant NKT Cell Activation

Bialecki, Emilie; Paget, Christophe; Fontaine, Josette; Capron, Moníque; Trottein, François; Faveeuw, Christelle

doi:10.4049/jimmunol.0802273

Cited by 57 publications

(61 citation statements)

References 60 publications

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“…In one of these studies, MZ B cells required DCs to activate NKT cells [7]. This raises the question as to whether our results are also due to DCs present in the cell preparations.…”

Section: Discussionmentioning

confidence: 51%

“…Supporting Information Fig. 1 [4][5][6][7] that MZ B cells express high levels of CD1d. In fact, expression of this molecule by MZ B cells was seven to eight times higher than its expression by cDCs, two to three times higher when compared with splenic B cells and 4.5 times higher when compared with B1 cells from peritoneal cavity (Supporting Information Fig.…”

Section: Mz B Cells Express High Levels Of Cd1 and Co-stimulatory Molmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The major subset of CD1d-restricted murine NKT cells (invariant or type I) expresses a semi-conservative T-cell receptor (TCR) consisting of Va14-Ja18 in conjunction with Vb8.2, Vb7 or Vb2 (7,8,16). This population is able to recognize the glycolipid ligand a-galactosylceramide (aGalCer) bound to CD1d.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, MZ B cells have been shown to continuously shuttle between MZ and white pulp, which allows them to transport antigens into the follicles [3]. Remarkably, when compared to other mouse APCs, MZ B cells were found to express high levels of CD1d, the non-classical MHC I molecule responsible for presentation of lipid or glycolipid antigens to NKT cells [4][5][6][7].The major subset of CD1d-restricted murine NKT cells (invariant or type I) expresses a semi-conservative T-cell receptor (TCR) consisting of Va14-Ja18 in conjunction with Vb8.2, Vb7 or Vb2 (7,8,16). This population is able to recognize the glycolipid ligand a-galactosylceramide (aGalCer) bound to CD1d.…”

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ICOS‐dependent stimulation of NKT cells by marginal zone B cells

et al. 2011

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Marginal zone (MZ) B cells express high levels of CD1d molecules. In accordance, MZ B cells, like splenic conventional DCs (cDCs), efficiently trigger NKT-cell proliferation. Importantly, MZ B cells exclusively induced production of IL-4 and IL-13 by such cells whereas cDCs induced robust production of mainly IFN-c. NKT-cell proliferation, IL-4 and IL-13 production induced by MZ B cells were dependent on ICOS/ICOS ligand interaction while IFN-c and IL-17 induction by cDCs required glucocorticoid-induced TNF receptor/ glucocorticoid-induced TNF receptor ligand interplay. Our data illustrate that both MZ B cells and cDCs act as efficient APCs for NKT cells and might differentially influence the quality of the subsequent immune response. IntroductionThe marginal zone (MZ) represents a unique structure in spleen that surrounds the primary follicles. It consists of a mixture of different types of cells that include macrophages, DCs, NKT cells as well as so-called MZ B cells. MZ B cells are enriched in germline-encoded specificities with low level of self-reactivity [1]. Therefore, they are maintained in a pre-activated state, which allows them to respond rapidly and T-cell independently to pathogens by antibody production. In addition, MZ B cells express high levels of the complement receptor CD21, which may enhance their response to complement coated antigens. This results in short-lived antibody responses to antigenic determinants expressed on invading viral and encapsulated bacterial species [2]. Due to their strategic location, MZ B cells, in concert with other innate cells, serve as a first line of defense against blood-borne antigens that reach the spleen [1,2]. Beyond their fast and efficient protective antibody response, MZ B cells exhibit additional important functions. They were shown to directly activate T cells and interact with APCs [1]. Moreover, MZ B cells have been shown to continuously shuttle between MZ and white pulp, which allows them to transport antigens into the follicles [3]. Remarkably, when compared to other mouse APCs, MZ B cells were found to express high levels of CD1d, the non-classical MHC I molecule responsible for presentation of lipid or glycolipid antigens to NKT cells [4][5][6][7].The major subset of CD1d-restricted murine NKT cells (invariant or type I) expresses a semi-conservative T-cell receptor (TCR) consisting of Va14-Ja18 in conjunction with Vb8.2, Vb7 or Vb2 (7,8,16). This population is able to recognize the glycolipid ligand a-galactosylceramide (aGalCer) bound to CD1d. Yet, existence of a smaller, so-called variant (or type II), CD1d-restriced NKT-cell population was also shown [8,9] This population expresses a diverse repertoire of TCRab and is unable to recognize aGalCer.Ã These authors contributed equally to this work. 3125The biological function of NKT cells seems paradoxical. They are able to rapidly produce large amounts of either T H 1 or T H 2 as well as T H 17 cytokines [10,11] and might promote immune responses in some settings but suppress cell-mediated immun...

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“…In one of these studies, MZ B cells required DCs to activate NKT cells [7]. This raises the question as to whether our results are also due to DCs present in the cell preparations.…”

Section: Discussionmentioning

confidence: 51%

Section: Mz B Cells Express High Levels Of Cd1 and Co-stimulatory Molmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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ICOS‐dependent stimulation of NKT cells by marginal zone B cells

et al. 2011

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CD1d ‐Restricted Natural Killer T Cells

Hill

Bezbradica

Kaer

et al. 2016

Encyclopedia of Life Sciences

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Natural killer T (NKT) cells that express the semi‐invariant T‐cell receptor are innate‐like lymphocytes whose functions are controlled by self and foreign glycolipid ligands. Such ligands are presented by the antigen‐presenting, MHC class I‐like molecule CD1d, which belongs to a family of lipid antigen‐presenting molecules collectively called CD1. Activation of NKT cells in vivo results in rapid release of copious amounts of effector cytokines and chemokines with which they regulate innate and adaptive immune responses to pathogens, certain types of cancers and self‐antigens. The nature of CD1d‐restricted ligands, the manners in which they are recognised and the unique effector functions of NKT cells suggest an immunoregulatory role for this T‐cell subset. Their ability to respond fast and our ability to steer NKT cell cytokine responses to altered lipid ligands make them an important target for vaccine design and immunotherapies against autoimmune diseases. This article summarises our current understanding of CD1d‐restricted NKT cell biology and how these innate‐like lymphocytes control inflammation. Key Concepts CD1d molecules belong to a family of lipid antigen‐presenting molecules collectively called CD1. CD1d molecules resemble peptide antigen‐presenting MHC class I molecules. CD1d molecules restrict the specificity and functions of Natural killer T (NKT) cells. NKT cells recognise self‐ and nonself‐lipid ligands. Antigen recognition quickly activates NKT cells, which respond immediately by releasing proinflammatory and immunoregulatory cytokines and chemokines. Activated NKT cells communicate with cells of the innate and adaptive immune systems by cell–cell interactions and/or via soluble mediators. Such communications allow NKT cells to control immune responses to microbial pathogens and certain cancers. NKT‐cell activation has beneficial and, sometimes, adverse effects on certain autoimmune and metabolic disorders. NKT cells are targets for vaccine adjuvants and immunotherapies.

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Regulatory B cells and advances in transplantation

Luo

Wang

et al. 2018

Journal of Leukocyte Biology

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The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand–receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL‐10. In experimental animal models, the extensively studied IL‐10‐producing B cells have shown unique therapeutic advantages in the transplant field. In addition, adoptive transfer of B cell subsets with regulatory activity may reveal a new approach to prolonging allograft survival. Recent clinical observations on currently available therapies targeting B cells have revealed that Bregs play an important role in immune tolerance and that these cells are expected to become a new target of immunotherapy for transplant‐related diseases.

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Role of Marginal Zone B Lymphocytes in Invariant NKT Cell Activation

Cited by 57 publications

References 60 publications

ICOS‐dependent stimulation of NKT cells by marginal zone B cells

ICOS‐dependent stimulation of NKT cells by marginal zone B cells

CD1d ‐Restricted Natural Killer T Cells

Regulatory B cells and advances in transplantation

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