Role of myosin 1H gene polymorphisms in mandibular retrognathism

Arun, R; Lakkakula, Bhaskar Vks; Chitharanjan, Arun B

doi:10.1016/j.ajodo.2015.10.028

Cited by 32 publications

(30 citation statements)

References 26 publications

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“…A study by Arun et al evaluated MYO1H gene polymorphisms and haplotypes as risk factors for mandibular retrognathism and identified a single-nucleotide polymorphism rs3825393 to be associated with mandibular retrognathism. 132 Previous studies have shown that there are distinct combinations of myosin heavy chain isoforms in the masseter muscles and that these muscle combinations may have mutual effects on bones. SCD patients may have a genetic predisposition for mandibular retrognathism influencing their susceptibility to develop OSAS.…”

Section: Lower Facial Skeletons In Scdmentioning

confidence: 99%

<p>Sleep-disordered breathing and comorbidities: role of the upper airway and craniofacial skeleton</p>

Brennan

Kirkham

Gavlak

2020

NSS

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Obstructive sleep-disordered breathing (SDB), which includes primary snoring through to obstructive sleep apnea syndrome (OSAS), may cause compromise of respiratory gas exchange during sleep, related to transient upper airway narrowing disrupting ventilation, and causing oxyhemoglobin desaturation and poor sleep quality. SDB is common in chronic disorders and has significant implications for health. With prevalence rates globally increasing, this condition is causing a substantial burden on health care costs. Certain populations, including people with sickle cell disease (SCD), exhibit a greater prevalence of OSAS. A review of the literature provides the available normal polysomnography and oximetry data for reference and documents the structural upper airway differences between those with and without OSAS, as well as between ethnicities and disease states. There may be differences in craniofacial development due to atypical growth trajectories or extramedullary hematopoiesis in anemias such as SCD. Studies involving MRI of the upper airway illustrated that OSAS populations tend to have a greater amount of lymphoid tissue, smaller airways, and smaller lower facial skeletons from measurements of the mandible and linear mental spine to clivus. Understanding the potential relationship between these anatomical landmarks and OSAS could help to stratify treatments, guiding choice towards those which most effectively resolve the obstruction. OSAS is relatively common in SCD populations, with hypoxia as a key manifestation, and sequelae including increased risk of stroke. Combatting any structural defects with appropriate interventions could reduce hypoxic exposure and consequently reduce the risk of comorbidities in those with SDB, warranting early treatment interventions.

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Section: Lower Facial Skeletons In Scdmentioning

confidence: 99%

<p>Sleep-disordered breathing and comorbidities: role of the upper airway and craniofacial skeleton</p>

Brennan

Kirkham

Gavlak

2020

NSS

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“…In a recent article, Sun et al (2018) have shown that the expression of MYO1H orthologous genes were detected at mandibular jaw of zebrafish model, whereby jaw cartilage defects were demonstrated in the MYO1H knockdown model. These developmental and functional studies strongly demonstrate the importance of MYO1H gene for proper jaw growth and development and its contribution towards the pathogenesis of mandibular prognathism and mandibular retrognathism in human (Arun et al, 2016;Sun et al, 2018). Tassopoulou-Fishell et al (2013) reported significant association between MYO1H SNP (rs10850110) with mandibular prognathism patients whom are mostly Caucasian.…”

Section: Myo1h Genesmentioning

confidence: 89%

“…Class 1 myosin is necessary for cell motility; phagocytosis and vesicle transport (Rowlerson et al, 2005). Myosin heavy chain isoforms was revealed to be found in the masseter muscle via immunohistochemical staining and gene expression studies (Arun et al, 2016). Few studies suggest that muscle affect the skeletal growth during embryonic stage, postnatal stage, and homeostatic relationship in adult and aging process (Brotto, 2015).…”

Section: Myo1h Genesmentioning

confidence: 99%

Genetics of malocclusion: A review

Mokhtar¹,

Bakar

Tahir

2020

IJOHS

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Malocclusion is one of the most common craniofacial problems observed worldwide. Affected individuals suffer not only from aesthetic concerns but also from functional problems, such as with mastication and pronunciation. The prevalence of malocclusion in East Asians is higher than in other races. Reports have shown besides environmental factors, there is association between certain types of malocclusion with specific genes. Positive association of mandibular prognathism has been implicated to genes such as Matrilin-1; while mutation in DUSP6 has also been shown to contribute to the incidence of malocclusion. This review aimed to briefly discuss the involvement of other additional genes such as MYO1H and PAX9 in the incidence of malocclusion as observed from our local institution.

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“…The research of Balkhande et al has shown that there is a correlation between mandibular retrognathism and matrilin-1 gene [ 4 ]. The myosin 1H gene is also thought to be closely related to mandibular retrognathism [ 5 ]. In addition, genes such as KAT6B , HDAC4 , and GHR are also considered to be related to mandibular retrognathism [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%