Role of nitric oxide and neuropeptides in neurogenic vasodilatation of the guinea pig mesenteric artery

Gyoda, Yasuaki; Tsukada, Yuichi; Saito, Akira; Goto, Katsutoshi

doi:10.1016/0014-2999(95)00142-8

Cited by 17 publications

(12 citation statements)

References 21 publications

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“…Moreover, endothelial-derived substances have been shown to interfere with CGRP and VIP-release from sensory nerves [43,44] and hence, in the presence of the endothelium and its stimulation by vasoconstriction the release of vasodilative mediators by NANC-nerves is altered. Finally, an independent action of nNOS-derived NO and CGRP or VIP has been reported before [15].…”

Section: Discussionmentioning

confidence: 92%

“…In contrast, no clear vascular iNOSprotein expression could be demonstrated [14]. Perivascular presence of nNOS-containing, so called nitrergic, nerves perivascular has been demonstrated in numerous vascular beds and multiple species [15][16][17][18][19][20]. Functional studies underline the importance of these adventitial nNOSimmunoreactive fibers for regulation of vascular tone and mediating neurogenic vasodilation by releasing NO [19,21,22].…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Up-regulation of nNOS and associated increase in nitrergic vasodilation in superior mesenteric arteries in pre-hepatic portal hypertension

Jurzik

Froh

Straub

et al. 2005

Journal of Hepatology

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Up-regulation of nNOS and associated increase in nitrergic vasodilation in superior mesenteric arteries in pre-hepatic portal hypertension

Jurzik

Froh

Straub

et al. 2005

Journal of Hepatology

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“…In dog (Toda et al, 1991b), monkey (Toda and Okamura, 1992b), cow (Ahlner et al, 1991;Leckstrom et al, 1993), and guinea pig mesenteric arteries (Gyoda et al, 1995) partially contracted with vasoconstrictors, electrical nerve stimulation or nicotine caused a contraction that was reversed to a relaxation by treatment with ␣-adrenoceptor antagonists or adrenergic neuron blockers. The relaxation was independent of the endothelium and was abolished by the L-enantiomers of NOS inhibitors, and L-arginine restored the response.…”

Section: Digestive Tract Vasculaturementioning

confidence: 99%

“…It was suggested that CGRP is also involved (Gyoda et al, 1995) or the sole mediator (Matsuda et al, 1995) in the neurogenic relaxation in guinea pig mesenteric artery. Endothelium-independent neurogenic relaxation was supposed to be mediated by CGRP from capsaicinsensitive C fibers in rabbit mesenteric arteries (Kakuyama et al, 1998).…”

Section: Digestive Tract Vasculaturementioning

confidence: 99%

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

2003

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“…Similar locally mediated vasodilation may be a feature of POTS even in the absence of feeding. Biochemicals such as vasoactive intestinal polypeptide, substance P, CGRP, and NO are capable of producing vasodilation despite an intact autonomic nervous system and are known to antagonize sympathetic vasoconstrictive effects (9,14,16,35). Further speculation concerning these matters remains outside of the scope of the present investigation.…”

Section: Discussionmentioning

confidence: 79%

Splanchnic hyperemia and hypervolemia during Valsalva maneuver in postural tachycardia syndrome

Stewart¹,

Medow²,

Montgomery³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

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Prior work demonstrated dependence of the change in blood pressure during the Valsalva maneuver (VM) on the extent of thoracic hypovolemia and splanchnic hypervolemia. Thoracic hypovolemia and splanchnic hypervolemia characterize certain patients with postural tachycardia syndrome (POTS) during orthostatic stress. These patients also experience abnormal phase II hypotension and phase IV hypertension during VM. We hypothesize that reduced splanchnic arterial resistance explains aberrant VM results in these patients. We studied 17 POTS patients aged 15-23 yr with normal resting peripheral blood flow by strain gauge plethysmography and 10 comparably aged healthy volunteers. All had normal blood volumes by dye dilution. We assessed changes in estimated thoracic, splanchnic, pelvic-thigh, and lower leg blood volume and blood flow by impedance plethysmography throughout VM performed in the supine position. Baseline splanchnic blood flow was increased and calculated arterial resistance was decreased in POTS compared with control subjects. Splanchnic resistance decreased and flow increased in POTS subjects, whereas splanchnic resistance increased and flow decreased in control subjects during stage II of VM. This was associated with increased splanchnic blood volume, decreased thoracic blood volume, increased heart rate, and decreased blood pressure in POTS. Pelvic and leg resistances were increased above control and remained so during stage IV of VM, accounting for the increased blood pressure overshoot in POTS. Thus splanchnic hyperemia and hypervolemia are related to excessive phase II blood pressure reduction in POTS despite intense peripheral vasoconstriction. Factors other than autonomic dysfunction may play a role in POTS.vasoconstriction; splanchnic arterial resistance; mesenteric artery; autonomic dysfunction; orthostatic intolerance IN PREVIOUS WORK WE DEMONSTRATED (31) the dependence of decrease in blood pressure on degree of thoracic hypovolemia during phase II of the Valsalva maneuver in healthy volunteers. We later showed that splanchnic hypervolemia during the Valsalva maneuver determines the magnitude of decrease in thoracic blood volume during early phase II of the maneuver (31). This, in turn, governs pressure recovery during late phase II (31).Prior work has shown that postural tachycardia syndrome (POTS), characterized by excessive tachycardia when upright in association with symptoms of orthostatic intolerance, is linked to thoracic hypovolemia (31). In POTS, thoracic hypovolemia may be produced by absolute hypovolemia, as observed in a variant of POTS with low peripheral blood flow (15), or may be produced by an excessive redistribution of blood volume away from the thoracic compartment, as observed in other variants (33). One such subset of POTS patients with redistributive thoracic hypovolemia, we designated "normal-flow POTS." This variant is characterized by normovolemia, normal cardiac output, and normal peripheral blood flow while resting supine. During orthostasis, however, there is thoracic ...

show abstract

Role of nitric oxide and neuropeptides in neurogenic vasodilatation of the guinea pig mesenteric artery

Cited by 17 publications

References 21 publications

Up-regulation of nNOS and associated increase in nitrergic vasodilation in superior mesenteric arteries in pre-hepatic portal hypertension

Up-regulation of nNOS and associated increase in nitrergic vasodilation in superior mesenteric arteries in pre-hepatic portal hypertension

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

Splanchnic hyperemia and hypervolemia during Valsalva maneuver in postural tachycardia syndrome

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