Role of normothermic machine perfusion in liver transplantation: Current trends and outcomes

Moein, Mahmoudreza; Capelin, Johnathan; Toth, Joseph; Tylor, Dylan; Weiss, Z; Murugesan, Bhavani G.; Saidi, Reza F.

doi:10.1016/j.sipas.2022.100077

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…Technological advancements for ‘de-fatting’ livers prior to transplant may hold future promise for improving both utilization and outcomes with these grafts [118]. A recent systematic review found that NMP holds immense potential to recondition and improve evaluation of less-than-ideal liver grafts [119 ▪ ], while remaining cost-effective compared with static cold storage [120].…”

Section: Other Notable Opportunities To Increase Liver Utilizationmentioning

confidence: 99%

Beyond donation to organ utilization in the USA

Stewart

Lonze

2023

Current Opinion in Organ Transplantation

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Purpose of reviewThe deceased donor organ pool has broadened beyond young, otherwise healthy head trauma victims. But an abundance of donated organs only benefits patients if they are accepted, expeditiously transported and actually transplanted. This review focuses on postdonation challenges and opportunities to increase the number of transplants through improved organ utilization. Recent findingsWe build upon recently proposed changes in terminology for measuring organ utilization. Among organs recovered for transplant, the nonuse rate (NUR REC ) has risen above 25% for kidneys and pancreata. Among donors, the nonuse rate (NUR DON ) has risen to 40% for livers and exceeds 70% for thoracic organs. Programme-level variation in offer acceptance rates vastly exceeds variation in the traditional, 1-year survival benchmark. Key opportunities to boost utilization include donation after circulatory death and hepatitis C virus (HCV)þ organs; acute kidney injury and suboptimal biopsy kidneys; older and steatotic livers.

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Section: Other Notable Opportunities To Increase Liver Utilizationmentioning

confidence: 99%

Beyond donation to organ utilization in the USA

Stewart

Lonze

2023

Current Opinion in Organ Transplantation

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“…However, transport of living cells, tissue cultures, organs on chips, and bioengineered tissues under warm physiological conditions is becoming more common 8 , and we anticipate that normothermic perfusion will become more important with time particularly as a means of assessing organs prior to transplantation in combination with the low-temperature storage strategies discussed in the following sections. Normothermic liver preservation by perfusion can lead to the expansion of the liver donor pool by increased use of livers from donors after cardiac death compared with traditional static cold liver storage 9 , 10 . Normothermic machine perfusion preservation of deceased donor livers reduces both posttransplant early allograft dysfunction and ischemic biliary complications 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Normothermic liver preservation by perfusion can lead to the expansion of the liver donor pool by increased use of livers from donors after cardiac death compared with traditional static cold liver storage 9 , 10 . Normothermic machine perfusion preservation of deceased donor livers reduces both posttransplant early allograft dysfunction and ischemic biliary complications 9 .…”

Section: Introductionmentioning

confidence: 99%

Freezing Biological Time: A Modern Perspective on Organ Preservation

Criswell

Swart²,

Stoudemire

et al. 2022

Stem Cells Translational Medicine

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Transporting tissues and organs from the site of donation to the patient in need, while maintaining viability, is a limiting factor in transplantation medicine. One way in which the supply chain of organs for transplantation can be improved is to discover novel approaches and technologies that preserve the health of organs outside of the body. The dominant technologies that are currently in use in the supply chain for biological materials maintain tissue temperatures ranging from a controlled room temperature (+25 °C to +15 °C) to cryogenic (−120 °C to −196 °C) temperatures (reviewed in Criswell et al. Stem Cells Transl Med. 2022). However, there are many cells and tissues, as well as all major organs, that respond less robustly to preservation attempts, particularly when there is a need for transport over long distances that require more time. In this perspective article, we will highlight the current challenges and advances in biopreservation aimed at “freezing biological time,” and discuss the future directions and requirements needed in the field.

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Role of normothermic machine perfusion in liver transplantation: Current trends and outcomes

Cited by 2 publications

References 27 publications

Beyond donation to organ utilization in the USA

Beyond donation to organ utilization in the USA

Freezing Biological Time: A Modern Perspective on Organ Preservation

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