Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

Abstract

PurposeRetinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG.MethodsA total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48). A complete ophthalmological examination including visual field examination, A-scan ultrasound, Fundus photography, and measurement of platelet parameters were performed for NVG subjects.ResultsThere was no statistical difference in the mean age and gender among the RVO, DR, and control groups (p>0.05). The mean level of platelet distribution width (PDW) was higher (p<0.001) in the RVO group (15.16±2.13fl) and DR group (16.17±1.66fl) when compared with the control group (13.77±2.99fl). The mean plateletcrit (PCT) value of the RVO group (0.229±0.063%) was also higher (p = 0.049) than the control group (0.199±0.045). In the DR group, mean platelet volume (MPV) value (10.72±1.57fl) was significantly higher (p = 0.002) than the control group (9.75±0.89fl). A similar trend was observed when platelet parameters were compared among the 3 groups with respect to age. The mean level of PDW was significantly higher (p<0.001) in the DR group (16.17±1.66fl) compared with the DM group (13.80±3.32fl). Stepwise multiple logistic regression analysis revealed that PDW (OR = 1.44, 95%CI = 1.149–1.805, p = 0.002) and MPV (OR = 1.503, 95%CI = 1.031–2.192, p = 0.034) were associated with the DR group, PDW (OR = 1.207, 95%CI = 1.010–1.443, p = 0.039) and PCT (OR = 1.663, 95%CI = 1.870–2.654, p = 0.036) were associated with the RVO group.ConclusionOur results suggest that increased PDW and MPV are associated with the NVG secondary to DR group, elevated PDW and PCT are associated with the RVO group. It indicates that platelets might be an important factor in the onset and/or development of NVG.

The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis

“…A total of 12 articles with 1681 patients explored the relationship between PDW and DR [ 21 , 23 , 32 , 50 , 58–60 , 65 , 67–69 , 71 ]. Considering the significant heterogeneity amongst the 12 studies ( I 2 = 79.3; P <0.01), random-effect model was applied when we performed the meta-analysis.…”

The relationship between mean platelet volume and diabetic retinopathy: a systematic review and meta-analysis

“…After duplicates were removed, only 42 full-text studies were evaluated. After exclusion of review and no-related articles, a total of 14 studies [ 10 – 23 ] were included in the final meta-analysis according to the inclusion criteria, including 2 cross-section studies [ 10 , 14 ] and 11 case control studies [ 11 – 13 , 15 – 23 ]. There are 1252 cases in the DR group, 1359 cases in T2DM without DR group and 1133 cases in control group.…”

Association between Platelet Parameters and Glaucoma Severity in Primary Open-Angle Glaucoma

“…Measuring platelet parameters, which can partially imply platelet function and activation, has been widely used to evaluate disease development and progression [12, 13]. Our previous study reported that mean platelet distribution width (PDW) and mean platelet volume (MPV), both of which are markers of platelet activation, were increased in patients with neovascular glaucoma and primary angle-closure glaucoma [14, 15]. To our knowledge, no previous study has investigated the association between platelet parameter and POAG.…”