Role of Positive Emotions in Takotsubo Cardiomyopathy

Sultana, Syeda S.; Nisar, Sibtain; Kumar, FNU Manoj; Khan, Haysum; Saeed, Hamayle; Ahmed, Gulfam; Malik, Jahanzeb

doi:10.1016/j.cpcardiol.2023.101997

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…Notably, acute exposure to nighttime noise‐related stress can even trigger a specific condition known as “stress cardiomyopathy” or “Takotsubo syndrome.” This condition is often referred to as “broken heart disease” because it can mimic the symptoms of a heart attack and is associated with extreme emotional stress. 10 Figure 1 shows the stress signaling by noise and leading to CVDs.…”

Section: Mechanism Of Noise Causing Cvdmentioning

confidence: 99%

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Association of transportation noise with cardiovascular diseases

Shah,

Raj,

Kaur

et al. 2024

Clinical Cardiology

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This comprehensive article delves into the intricate and multifaceted issue of noise pollution, shedding light on its diverse sources, profound health implications, and the economic burden it imposes on societies. Noise pollution is an increasingly prevalent environmental challenge, impacting millions of people worldwide, often without their full awareness of its adverse effects. Drawing from a wealth of scientific research, the article underscores the well‐established links between noise pollution and a spectrum of health issues, including cardiovascular diseases, sleep disturbances, and psychological stress. While exploring the sources and consequences of noise pollution, the article highlights the urgent need for a holistic and collaborative approach to mitigate its impact. This entails a combination of regulatory measures, technological innovations, urban planning strategies, and public education campaigns. It is increasingly evident that the detrimental effects of noise pollution extend beyond physical health, encompassing mental and social well‐being. The article also addresses the synergistic relationship between noise pollution and other environmental stressors, emphasizing the importance of considering noise in conjunction with factors like air pollution and access to green spaces. It examines the potential of green spaces to mitigate the effects of noise pollution and enhance overall health.

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Section: Mechanism Of Noise Causing Cvdmentioning

confidence: 99%

“…This condition is often referred to as "broken heart disease" because it can mimic the symptoms of a heart attack and is associated with extreme emotional stress. 10 Figure 1 shows the stress signaling by noise and leading to CVDs.…”

Section: Mechanism Of Noise Causing Cvdmentioning

confidence: 99%

Association of transportation noise with cardiovascular diseases

Shah,

Raj,

Kaur

et al. 2024

Clinical Cardiology

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View full text Add to dashboard Cite

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Histological and functional assessment of a Takotsubo cardiomyopathy model established by immobilization stress

Pei,

Yang,

et al. 2024

Pacing Clinical Electrophis

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IntroductionTakotsubo cardiomyopathy (TTC), also known as stress‐induced cardiomyopathy, resembles acute heart failure syndrome but lacks disease‐specific diagnosis and treatment strategies. TTC accounts for approximately 5–6% of all suspected cases of acute coronary syndrome in women. At present, animal models of TTC are often created by large amounts of exogenous catecholamines such as isoproterenol. However, isoproterenol injection cannot fully simulate the onset of stress‐induced cardiomyopathy in humans since stress is not an instantaneous event.MethodsRats were immobilized for 6 h per day for 1–14 days. To examine whether the TTC model was successful, echocardiography was employed; Elisa detected serum sympathetic activation markers; and the Open‐Field test (OFT) was used to analyze behavioral changes in rats after stress. Western blot and histology were used to assess sympathetic remodeling, inflammation levels, and fibrosis; qRT‐PCR was used to explore the levels of fibrosis and myocardial hypertrophy. The electrical stability of ventricular was determined by electrophysiological testing.ResultsThe rats showed severe stress behavior and local sympathetic remodeling of the heart after only 1 day of stress. After 3 days of stress, the induction of ventricular tachyarrhythmia increased prominently. The highest incidence of TTC in rats was at 5 days of immobilization stress. The pathological left ventricular remodeling caused by immobilization (IMO) stress includes inflammatory infiltration, fibrosis, and myocardial hypertrophy.ConclusionsOur study confirms the hypothesis that IMO stress can mimic Takotsubo cardiomyopathy, and the various effects on the heart depending on the duration of IMO stress. We observed the highest incidence of TTC occurred after 5 days of stress. Furthermore, there is a gradual occurrence of electrical and structural remodeling as the stress duration prolongs.

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Recovery of Left Ventricular Function and Long-Term Outcomes in Patients with Takotsubo Syndrome: A Case Series

Riaz,

Zahid,

Kumar

et al. 2024

Preprint

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AIM. The objective of this case series was to evaluate the recovery of left ventricular (LV) function and long-term outcomes in patients with Takotsubo Syndrome (TTS) and identify clinical predictors of major outcomes, including recurrence and complications. METHODS. This study included 32 patients diagnosed with TTS. Baseline characteristics, cardiac biomarkers, and electrocardiographic findings were documented. LV function, wall motion abnormalities, recurrence, complications, and quality of life were assessed at baseline, 3 months, 6 months, and 1 year. Logistic regression analysis was used to identify predictors of LV recovery and long-term complications. RESULTS. The mean age was 68 ± 10 years, with 90.6% of patients being female. LVEF improved from 35% ± 10% at baseline to 60% ± 5% at 1 year. Wall motion abnormalities resolved in 93.8% of patients, while recurrence of TTS occurred in 3.1% at 1 year. Younger age (< 65 years) and initial LVEF ≥ 30% were associated with better LV recovery. Emotional stress triggers and hypertension were significant predictors of long-term complications. Quality of life improved from 0.45 ± 0.15 to 0.85 ± 0.07 in 1 year, with a 96.9% survival rate. CONCLUSION. TTS patients generally experience favorable outcomes with significant LV recovery. Emotional stress and hypertension predict long-term complications, while younger age and higher initial LVEF indicate better recovery.

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Role of Positive Emotions in Takotsubo Cardiomyopathy

Cited by 3 publications

References 44 publications

Association of transportation noise with cardiovascular diseases

Association of transportation noise with cardiovascular diseases

Histological and functional assessment of a Takotsubo cardiomyopathy model established by immobilization stress

Recovery of Left Ventricular Function and Long-Term Outcomes in Patients with Takotsubo Syndrome: A Case Series

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