Role of Preoperative Dexamethasone Nebulization in Reducing Bougie Complications Encountered After Sleeve Gastrectomy: a Prospective Double-Blind Control Interventional Study

Almustafa, Mahmoud; Obeidat, Firas; Mismar, Ayman; Rashdan, Mohammad; Jabaiti, Khaled; AlRyalat, Saif Aldeen; Al-Hardan, Dalia; Suleiman, Aiman

doi:10.1007/s11695-019-04202-x

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…In agreement with our results, (7) A prospective interventional study that included 80 patients. The patients were assigned to two groups, 40 patients in each group: the dexamethasone group (D) which received nebulized dexamethasone 8 mg 1 h before surgery and the control group (S) which received saline nebulizer instead.…”

Section: Justification Of Sample Sizesupporting

confidence: 92%

Post-Extubation Sore Throat; How Far Nebuliz

Mohamed

Farag

Mostafa

et al. 2021

Ain Shams Medical Journal

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Background: Post-operative sore throat (POST) is a frequent complaint that occurs in 21-65% of patients receiving general anesthesia (GA) with endotracheal intubation. Effective prevention of postoperative sore throat is thus needed. The inhaled corticosteroids deliver the drug to the site of action without systemic effects. Dexamethasone is a potent synthetic glucocorticoid with anti-inflammatory effects.

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Section: Justification Of Sample Sizesupporting

confidence: 92%

Post-Extubation Sore Throat; How Far Nebuliz

Mohamed

Farag

Mostafa

et al. 2021

Ain Shams Medical Journal

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“…In addition to preventing POST, cough and hoarseness, prophylactic administration of corticosteroids has been reported to reduce the incidence of postoperative laryngeal edema and reintubation[ 41 ]. The nebulized corticosteroids included in this review include dexamethasone(8mg)[ 10 , 42 , 43 ], budesonide(0.2mg-0.5mg)[ 23 , 43 ], beclomethasone(50μg)[ 44 , 45 ], mometasone[ 46 ], and fluticasone(0.5mg)[ 47 ]. We were trying to figure out which corticosteroids had the best effects.…”

Section: Discussionmentioning

confidence: 99%

Nebulized pharmacological agents for preventing postoperative sore throat: A systematic review and network meta-analysis

Ren

Min

et al. 2020

PLoS ONE

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Postoperative sore throat is one of the most common complications following endotracheal intubation. Nebulization therapy, a preferable and safety method of drug delivery, has been shown to be effective in postoperative sore throat prevention in many studies. However, the relative efficacy of various nebulized agents remains unknown. In this review, we aimed to quantify and rank order the efficacy of available nebulized agents for various postoperative sore throat-related outcomes. A comprehensive literature search of PubMed, EMBASE, CENTRAL and Google Scholar was conducted to identify eligible studies from inception to 25 May 2020. Incidence of postoperative sore throat 1hour and 24hours postoperatively and severity of postoperative sore throat 24 hours postoperatively were the primary outcomes. We conducted a Bayesian network meta-analysis to combine direct and indirect evidence to estimate the relative effects between treatments as well as the probabilities of ranking for treatments based on their protective effects. We identified 32 trials assessing 6 interventions. Overall inconsistency and heterogeneity were acceptable. Nebulized corticosteroids, magnesium, and ketamine differed from non-analgesic methods on the three primary outcomes. Based on the surface under the cumulative ranking curve, nebulized corticosteroids ranked first in almost all outcomes among the nebulized drugs. Considering only high-quality and 2-arm design studies, nebulized corticosteroids still seemed best. In conclusion, prophylactic use of nebulized corticosteroids, magnesium, and ketamine can effectively prevent postoperative sore throat, and nebulized corticosteroids appears to be the overall best approach.

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“…The incidence of POST was 27.5% compared to 72.5% in the dexamethasone and control groups respectively (P < 0.05). 13 Due to its anti-nociceptive and anti-inflammatory properties, ketamine, an NMDA receptor antagonist, has been administered as a gargle or nebulizer to lessen the frequency and intensity of POST. 14 Interestingly, a prior study by Nejati et al (2010) supported intranasal ketamine in lowering pain related to nasogastric tube placement.…”

Section: Discussionmentioning

confidence: 99%

Role of preoperative dexamethasone nebulization versus ketamine nebulization in reducing complications of nasogastric tube after laparoscopic surgery

Zakaria,

Aboulella,

Hassanein

et al. 2024

Anaesth. pain intensive care

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Background & objective: Nasogastric (NG) tube insertion is a frequently performed medical procedure. Most of the time, the oropharyngeal discomfort is usually underestimated, and insertions are carried out with just regular lubricant jelly and no additional painkillers, which results in less-than-ideal pain management. We compared the effectiveness of preemptive use of nebulized ketamine and dexamethasone in preventing post-operative sore throat following NG tube insertion in laparoscopic surgery. Methods: This prospective randomized double-blind controlled study was carried on 108 patients of both sexes with ASA physical status I-II. aged 20-60 years, undergoing laparoscopic abdominal surgeries under general anesthesia. Patients were randomized into 3 equal groups. Group D received a dose of 8 mg nebulized dexamethasone. Group K received 50 mg nebulized ketamine. Group S received 5 ml of nebulized saline. NG tube was passed after induction of general anesthesia. Postoperative sore throat was enquired from the patients at full recovery (zero hour), then at 2, 8, 12 and 24 h. Computer software (SPSS 15.0.1. for Windows; SPSS Inc, Chicago, IL, 2001) was used for data analysis. Non-parametric quantitative data, median, range, percentages, and numbers are given for qualitative data. The appropriate analysis was conducted in line with the data obtained. P < 0.05 was regarded as significant. Results: The incidence of postoperative sore throat (POST) was lower with both nebulized dexamethasone and nebulized ketamine compared with nebulized saline; and significantly lower with dexamethasone compared with ketamine at 0 h (P < 0.001), 2 h (P < 0.001), 8 h (P < 0.001), 12 h (P < 0.001), and 24 h (P < 0.001). Conclusion: The current study revealed that preoperative nebulized dexamethasone was more effective than nebulized ketamine in reducing postoperative sore throat. Abbreviations: NG- Nasogastric; NMDA- N-Methyl-D-Aspartate; PONV- Postoperative Nausea and Vomiting; POST- Postoperative Sore Throat; VAS- Visual Analogue Scale Key words: Nebulization; Dexamethasone; Ketamine; Laparoscopic Surgery; Nasogastric Tube Citation: Zakaria MM, Mohammed Aboulella SK, Hassanein SMK, Elsayed El Hennawy AM, Salah El Din Shabana TS. Role of preoperative dexamethasone nebulization versus ketamine nebulization in reducing complications of nasogastric tube after laparoscopic surgery. Anaesth. pain intensive care 2024;28(1):62-67. DOI: 10.35975/apic.v28i1.2275 Received: 22 July, 2023; Reviewed: 04 October 2023; Accepted: 30 October 2023

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Role of Preoperative Dexamethasone Nebulization in Reducing Bougie Complications Encountered After Sleeve Gastrectomy: a Prospective Double-Blind Control Interventional Study

Cited by 6 publications

References 23 publications

Post-Extubation Sore Throat; How Far Nebuliz

Post-Extubation Sore Throat; How Far Nebuliz

Nebulized pharmacological agents for preventing postoperative sore throat: A systematic review and network meta-analysis

Role of preoperative dexamethasone nebulization versus ketamine nebulization in reducing complications of nasogastric tube after laparoscopic surgery

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