Role of Presepsin for the Assessment of Acute Cholangitis Severity

Lin, Jinkun; Sun, Haiqing; Jiangong, LI; Zheng, Yanhong; Shao, Chengchen; Zhang, Yang Hong; Chang, Hong

doi:10.7754/clin.lab.2015.150832

Cited by 10 publications

(8 citation statements)

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“…In another recent prospective study, procalcitonin was found to be increased significantly in either moderate or severe AC (28). Another inflammatory marker Presepsin was found to be significantly higher in patients with severe AC than in patients with moderate AC or with mild AC (29). In our study we found that IL-33 increased significantly in patients with moderate/severe AC who need immediate biliary drainage.…”

Section: Resultssupporting

confidence: 64%

İnterlökin-33 Düzeylerinin Erken veya Acil Safra Drenajı Gerektiren Akut Kolanjitli Hastalarda Tanısal Kullanımı

Gökbulut¹,

Ödemiş²,

Kalkan³

et al. 2021

Akdeniz Medical Journal

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Objective: Treatment of cholangitis is life-saving in patients with severe acute cholangitis (AC). We aimed to investigate usefulness of interleukin-33 (IL-33) to discriminate need of early or urgent biliary drainage in patients with acute cholangitis according to Tokyo Guidelines 2018 (TG18) grading system. Material and Methods:The study population consisted of a total of 79 subjects (48 AC and 31 healthy controls). Patients with AC were categorized based on TG18, and the IL-33 levels and laboratory markers were measured. Results: IL-33 level was significantly higher in the AC group (p <0.0001). ROC curve analysis was performed to distinguish patients with AC from normal healthy patients and to determine a cutoff value for IL-33. As a result of this analysis, the cut-off value for serum IL-33 was 0.59 pg / mL (sensitivity: 83.3% (95% CI: 69.8-92.5), specificity: 90.3% (95% CI: 74.2-98.0)) and the area under the ROC curve (AUC) was found to be 0.902 (p <0.0001; 95% CI: 0.814-0.957). The median IL-33 level was significantly higher in patients who needed early/emergency biliary drainage (moderate or severe AC) compared to patients with mild AC (0.79 vs 0.60, p = 0.01). Conclusion:This study showed that IL-33 increased significantly in patients with moderate/severe AC who need immediate biliary drainage.

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Section: Resultssupporting

confidence: 64%

İnterlökin-33 Düzeylerinin Erken veya Acil Safra Drenajı Gerektiren Akut Kolanjitli Hastalarda Tanısal Kullanımı

Gökbulut¹,

Ödemiş²,

Kalkan³

et al. 2021

Akdeniz Medical Journal

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“…Although the distributions also differed by the type of infection (Figure 3), which seemed to reflect the severity of infection and organ damage, the low incidence of complications prevented us from analyzing the diagnostic superiority of presepsin between local and systematic infections, which requires further investigation. However, given that the reported median or mean values of presepsin for local infection ranged from 590 to 721 pg/mL according to a very small number of studies, 2,28 our data are reasonable.…”

Section: Discussionmentioning

confidence: 50%

Diagnostic potential of presepsin in bacterial infection following hepato‐biliary‐pancreatic surgery: A prospective observational study

Yao

Kaido

Uozumi

et al. 2020

J Hepato Biliary Pancreat

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Background/Purpose: The aim in the present study was to elucidate the diagnostic ability of presepsin for postoperative infectious complications following major hepato-biliary-pancreatic (HBP) surgery. Methods: Between 2017 and 2019, 50 patients with major hepatectomy and 55 patients with pancreatoduodenectomy were enrolled. Presepsin, the neutrophil-tolymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin (PCT) were prospectively measured for the first 2 weeks after surgery. The diagnostic abilities of these biomarkers were compared multidirectionally. Results: All biomarkers returned to normal ranges within 2 weeks after surgery. However, presepsin, unlike the other biomarkers, showed less nonspecific elevation in response to the invasiveness of the surgical procedure immediately after surgery. Receiver operating characteristic curve analysis revealed that presepsin (area under the curve (AUC), 0.959) had a greater ability to discriminate bacterial infection than PCT (AUC, 0.723), CRP (AUC, 0.800), and the NLR (AUC, 0.804). A very high sensitivity of 93.3% and a specificity of 89.2% were achieved at the cutoff value of 620 pg/mL. Multivariable analysis revealed that presepsin on day 3 (P = .013) independently predicted bacterial infection after HBP surgery. Conclusions: Presepsin may have a better predictive ability than existing biomarkers for infection following major HBP surgery, which may help us achieve faster and more accurate detection of bacterial infections.

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“…It is an easy and effective scoring system, its usefulness has been con rmed, and it was taken over to the Updated Tokyo Guidelines for acute cholangitis and cholecystitis in 2018 [18,19]. Furthermore, PCT [6][7][8], endotoxin activity [20,21], NF-kB [22], IL-7 [23], delta-neutrophil index [24], and presepsin [25] have been reported as independent biomarkers for prognosis of acute cholangitis and PCT [6,23], endotoxin activity [20], and IL-7 [23] for bacteremia.…”

Section: Discussionmentioning

confidence: 99%

Proportion of Neutrophils in the White Blood Cells as a Useful Marker for Predicting Bacteremic Acute Cholangitis

Yamaguchi¹,

Wada²,

Moriuchi³

et al. 2021

Preprint

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Background A positive hemoculture in acute cholangitis is serious, and accordingly, a predictor for bacteremia at initial diagnosis would be particularly useful. We investigated the association between neutrophil proportion in the white blood cell count (Neut%) and bacteremic acute cholangitis. Methods In 166 patients of acute cholangitis diagnosed with Tokyo guideline 2013 from April 2014 to March 2015, ninety-four patients underwent blood culture assessment and were divided into a positive hemoculture (n = 48) and negative hemoculture (n = 46) group and these two group were compared. A receiver operating characteristic curve analysis was used to evaluate the predictive ability of Neut% and other inflammatory markers. Results Neut% was significantly higher in the positive hemoculture (91.7 ± 4.0% vs. 82.5 ± 9.0%, P < 0.0001). A cutoff Neut% value of 89.7% was strongly associated with bacteremia (area under the curve 0.86, sensitivity 77%, specificity 80%). A Neut% of ≥ 89.7% was a predictor of positive hemoculture in the univariate (P < 0.0001) and multivariate analyses (P < 0.001). Patients with a Neut% ≥89.7% needed early biliary drainage (30/46, 65.2% vs. 18/48, 37.5%, P = 0.0063). Conclusions Neut% is an independent predictor of bacteremia and prognosis in patients with acute cholangitis and may contribute to decision-making of early biliary drainage.

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Role of Presepsin for the Assessment of Acute Cholangitis Severity

Cited by 10 publications

References 0 publications

İnterlökin-33 Düzeylerinin Erken veya Acil Safra Drenajı Gerektiren Akut Kolanjitli Hastalarda Tanısal Kullanımı

İnterlökin-33 Düzeylerinin Erken veya Acil Safra Drenajı Gerektiren Akut Kolanjitli Hastalarda Tanısal Kullanımı

Diagnostic potential of presepsin in bacterial infection following hepato‐biliary‐pancreatic surgery: A prospective observational study

Proportion of Neutrophils in the White Blood Cells as a Useful Marker for Predicting Bacteremic Acute Cholangitis

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