Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease 1,2 1This article is part of a series of reviews on “Reactive Oxygen and Nitrogen in Inflammation.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Giuseppe Poli

Pavlick, Kevin P.; Laroux, F. Stephen; Fuseler, John W.; Wolf, Robert; Gray, Laura; Hoffman, Jason M.; Grisham, Matthew B.

doi:10.1016/s0891-5849(02)00853-5

Cited by 335 publications

(88 citation statements)

References 82 publications

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“…Many studies have revealed that reactive metabolites of oxygen and nitrogen are a notable characteristic of IBD, leading to the pathologic aggravation of a series of freeradical chain reactions and a strong attack on DNA, proteins, enzymes, and biological membranes as well as the disruption of the integrity and function of the intestinal mucosal barrier and activation of inflammatory mediators [37,38].…”

Section: Tnbs-induced Colitis Is a Hapten-induced Model Of Chronicmentioning

confidence: 99%

The Effect of Hypericum perforatum (St. John’s Wort) on Experimental Colitis in Rat

et al. 2008

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The aim of the present study was to investigate the effect of Hypericum perforatum (HP) on the inflammatory and immune response of colonic mucosa in rat with induced inflammatory bowel disease and that on various enzyme activities in blood and bowel tissue. Male Wistar albino rats were divided into three main groups: control, third day, and seventh day of colitis. Third-day and seventh-day groups were divided into four subgroups. Colitis was induced in all groups except the control group by 2,4,6-trinitrobenzene sulfonic acid (TNBS). The colitis group received saline; treatment groups received HP extract (50, 150, and 300 mg/kg/day, respectively). Glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) activities in blood were measured. Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples. Colonic damage was significantly reduced by HP extract. Macroscopic scoring of colonic damage significantly reduced in groups given HP extract compared with in the colitis group (P < 0.001). Blood catalase levels were reduced in the HP (150 mg/kg/day) compared with the colitis group (P < 0.01). Blood GSH levels significantly increased in groups treated with HP compared with control (P < 0.001) on the third and seventh day. Tissue GR levels reduced in the colitis and HP (50 mg/kg/day) groups compared with control (P < 0.05). Tissue MPO activity increased in the colitis and treatment groups compared with control (P < 0.007). GSH-Px levels increased in the colitis group compared with control at day 3 (P = 0.006). HP has a protective effect on TNBS-induced inflammatory bowel disease (IBD), probably due to an anti-inflammatory and antioxidant mechanism.

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Section: Tnbs-induced Colitis Is a Hapten-induced Model Of Chronicmentioning

confidence: 99%

The Effect of Hypericum perforatum (St. John’s Wort) on Experimental Colitis in Rat

et al. 2008

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“…Recent experimental and clinical studies suggest that initiation and pathogenesis of these diseases are multifactorial, involving interactions among genetic, environmental, and immune factors [2].…”

Section: Introductionmentioning

confidence: 99%

The Effect of iNOS Inhibitors and Hyperbaric Oxygen Treatment in a Rat Model of Experimental Colitis

et al. 2008

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“…[1][2][3][4][5] The oxidative stress through an excessive release of reactive oxygen species (ROS) has been proposed to play a key role in IBD pathogenesis. 6,7) Considering this, the use of antioxidant compounds may be useful in limiting damage in IBD. In fact, it has been proposed that antioxidant activity may be responsible for the beneficial effects showed by 5-aminosalycilate derivatives in human IBD.…”

mentioning

confidence: 99%

Intestinal Anti-inflammatory Activity of Coumarin and 4-Hydroxycoumarin in the Trinitrobenzenesulphonic Acid Model of Rat Colitis

Luchini

Rodrigues-Orsi

Cestari

et al. 2008

Biological & Pharmaceutical Bulletin

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Coumarins represent an important class of phenolic compounds with multiple biological activities, including inhibition of lipidic peroxidation and neutrophil-dependent anion superoxide generation, anti-inflammatory and immunosuppressor actions. All of these proprieties are essential for that a drug may be used in the treatment of inflammatory bowel disease. The present study examined intestinal anti-inflammatory activity of coumarin and its derivative, the 4-hydroxycoumarin on experimental ulcerative colitis in rats. This was performed in two different experimental settings, i.e. when the colonic mucosa is intact or when the mucosa is in process of recovery after an initial insult. The results obtained revealed that the coumarin and 4-hydroxycoumarin, at doses of 5 and 25 mg/kg, significantly attenuated the colonic damage induced by trinitrobenzenesulphonic acid (TNBS) in both situations, as evidenced macroscopically, microscopically and biochemically. This effect was related to an improvement in the colonic oxidative status, since coumarin and 4-hydroxycoumarin prevented the glutathione depletion that occurred as a consequence of the colonic inflammation.

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Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease 1,2 1This article is part of a series of reviews on “Reactive Oxygen and Nitrogen in Inflammation.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Giuseppe Poli

Cited by 335 publications

References 82 publications

The Effect of Hypericum perforatum (St. John’s Wort) on Experimental Colitis in Rat

The Effect of Hypericum perforatum (St. John’s Wort) on Experimental Colitis in Rat

The Effect of iNOS Inhibitors and Hyperbaric Oxygen Treatment in a Rat Model of Experimental Colitis

Intestinal Anti-inflammatory Activity of Coumarin and 4-Hydroxycoumarin in the Trinitrobenzenesulphonic Acid Model of Rat Colitis

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