Role of resveratrol in inhibiting pathological cardiac remodeling

Fan, Shaowei; Hu, Yuanhui; You, Yaping; Xue, Wenjing; Chai, Ruoning; Shou, Xintian; Shi, Jingjing

doi:10.3389/fphar.2022.924473

Cited by 21 publications

(10 citation statements)

References 213 publications

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“…Alcohol consumption had a protective role on mortality in our cohort, unlike in the literature ( 43 ), probably due to wine consumption rather than spirits. Red wine is a source of polyphenols, such as resveratrol and anthocyanin, with demonstrated antioxidant properties and protective role against cardiovascular diseases ( 44 – 46 ).…”

Section: Discussionmentioning

confidence: 99%

Contribution of macro- and micronutrients intake to gastrointestinal cancer mortality in the ONCONUT cohort: Classical vs. modern approaches

et al. 2023

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The aim of this study was to evaluate the contribution of macro- and micronutrients intake to mortality in patients with gastrointestinal cancer, comparing the classical statistical approaches with a new generation algorithm. In 1992, the ONCONUT project was started with the aim of evaluating the relationship between diet and cancer development in a Southern Italian elderly population. Patients who died of specific death causes (ICD-10 from 150.0 to 159.9) were included in the study (n = 3,505) and survival analysis was applied. This cohort was used to test the performance of different techniques, namely Cox proportional-hazards model, random survival forest (RSF), Survival Support Vector Machine (SSVM), and C-index, applied to quantify the performance. Lastly, the new prediction mode, denominated Shapley Additive Explanation (SHAP), was adopted. RSF had the best performance (0.7653711 and 0.7725246, for macro- and micronutrients, respectively), while SSVM had the worst C-index (0.5667753 and 0.545222). SHAP was helpful to understand the role of single patient features on mortality. Using SHAP together with RSF and classical CPH was most helpful, and shows promise for future clinical applications.

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Section: Discussionmentioning

confidence: 99%

Contribution of macro- and micronutrients intake to gastrointestinal cancer mortality in the ONCONUT cohort: Classical vs. modern approaches

et al. 2023

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“…The use of natural medicinal herbs in the treatment of cardiovascular disease is gradually gaining acceptance, and have been used in the clinical management of DCM for many years. Studies have also confirmed that some herbal formulas (Sun et al, 2017;Peng et al, 2022) and natural compounds can inhibit apoptosis (Fan et al, 2022), improve mitochondrial energy metabolism (Duan et al, 2015) and inhibit myocardial fibrosis (Chen Q. et al, 2022). A study of herbs associated with cuproptosis showed that most natural compounds, such as resveratrol and quercetin, mainly depend on folic acid to regulate cuproptosis-related genes (CRGs) (Dayuan et al, 2023).…”

Section: Introductionmentioning

confidence: 95%

Identification of cuproptosis-related biomarkers in dilated cardiomyopathy and potential therapeutic prediction of herbal medicines

Bian

Wang

et al. 2023

Front. Mol. Biosci.

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Background: Dilated cardiomyopathy (DCM) is one of the significant causes of heart failure, and the mechanisms of metabolic ventricular remodelling due to disturbances in energy metabolism are still poorly understood in cardiac pathology. Understanding the biological mechanisms of cuproptosis in DCM is critical for drug development.Methods: The DCM datasets were downloaded from Gene Expression Omnibus, their relationships with cuproptosis-related genes (CRGs) and immune signatures were analyzed. LASSO, RF, and SVM-RFE machine learning algorithms were used to identify signature genes and the eXtreme Gradient Boosting (XGBoost) model was used to assess diagnostic efficacy. Molecular clusters of CRGs were identified, and immune Infiltration analysis was performed. The WGCNA algorithm was used to identify specific genes in different clusters. In addition, AUCell was used to analyse the cuproptosis scores of different cell types in the scRNA-seq dataset. Finally, herbal medicines were predicted from an online database, and molecular docking and molecular dynamics simulations were used to support the confirmation of the potential of the selected compounds.Results: We identified dysregulated cuproptosis genes and activated immune responses between DCM and healthy controls. Two signature genes (FDX1, SLC31A1) were identified and performed well in an external validation dataset (AUC = 0.846). Two molecular clusters associated with cuproptosis were further defined in DCM, and immune infiltration analysis showed B-cell naive, Eosinophils, NK cells activated and T-cell CD4 memory resting is significant immune heterogeneity in the two clusters. AUCell analysis showed that cardiomyocytes had a high cuproposis score. In addition, 19 and 3 herbal species were predicted based on FDX1 and SLC31A1. Based on the molecular docking model, the natural compounds Rutin with FDX1 (-9.3 kcal/mol) and Polydatin with SLC31A1 (-5.5 kcal/mol) has high stability and molecular dynamics simulation studies further validated this structural stability.Conclusion: Our study systematically illustrates the complex relationship between cuproptosis and the pathological features of DCM and identifies two signature genes (FDX1 and SLC31A1) and two natural compounds (Rutin and Polydatin). This may enhance our diagnosis of the disease and facilitate the development of clinical treatment strategies for DCM.

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“… 396 Stimulation of SIRT3 reduces ROS and protein kinase levels and prevents cardiac hypertrophy, which may be a mechanism to inhibit cardiac remodeling. 397 Last, p300 is a potential therapeutic target for heart failure. Mice with p300 knockout exhibit remarkable cardiac defects and embryonic lethality (Table 3 ).…”

Section: Acetylationmentioning

confidence: 99%

“…The sirtuin family also plays key roles in preventing cardiomyocyte fibrosis, regulating cardiomyocyte apoptosis, improving cellular energy metabolism remodeling and inflammation, and maintaining cardiac homeostasis 396 . Stimulation of SIRT3 reduces ROS and protein kinase levels and prevents cardiac hypertrophy, which may be a mechanism to inhibit cardiac remodeling 397 . Last, p300 is a potential therapeutic target for heart failure.…”

Section: Acetylationmentioning

confidence: 99%

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong

Xiao

Xie

et al. 2023

MedComm

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Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent bonds on the backbones or amino acid side chains of proteins and expand the diversity of proteins, which provides the basis for the emergence of organismal complexity. To date, more than 650 types of protein modifications, such as the most well‐known phosphorylation, ubiquitination, glycosylation, methylation, SUMOylation, short‐chain and long‐chain acylation modifications, redox modifications, and irreversible modifications, have been described, and the inventory is still increasing. By changing the protein conformation, localization, activity, stability, charges, and interactions with other biomolecules, PTMs ultimately alter the phenotypes and biological processes of cells. The homeostasis of protein modifications is important to human health. Abnormal PTMs may cause changes in protein properties and loss of protein functions, which are closely related to the occurrence and development of various diseases. In this review, we systematically introduce the characteristics, regulatory mechanisms, and functions of various PTMs in health and diseases. In addition, the therapeutic prospects in various diseases by targeting PTMs and associated regulatory enzymes are also summarized. This work will deepen the understanding of protein modifications in health and diseases and promote the discovery of diagnostic and prognostic markers and drug targets for diseases.

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Role of resveratrol in inhibiting pathological cardiac remodeling

Cited by 21 publications

References 213 publications

Contribution of macro- and micronutrients intake to gastrointestinal cancer mortality in the ONCONUT cohort: Classical vs. modern approaches

Contribution of macro- and micronutrients intake to gastrointestinal cancer mortality in the ONCONUT cohort: Classical vs. modern approaches

Identification of cuproptosis-related biomarkers in dilated cardiomyopathy and potential therapeutic prediction of herbal medicines

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

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