Role of the Nervous System in Experimental Renal Hypertension

The behaviour of the blood pressure in normal and hypertensive rabbits in response to l‐noradrenaline and to ganglion block by hexa‐ or pentamethonium

“…Although this view has not been confirmed by others (Nickerson, Bullock & Nomaguchi, 1948;Moss & Wakerlin, 1950) the increased responses to hexa-or pentamethonium found in hypertension appear to be in partial agreement with the facts upon which this hypothesis was based, but the change in the sensitivity appears adequate to explain the apparently augmented nervous activity. Although the change in mechanism between hypertension of short and long duration is associated with increased sensitivity to noradrenaline and ganglion block, the fundamental mechanism responsible for the elevated pressure remains a humoral one.…”

“…Upon the evidence of increasing response to autonomic blocking agents, F 883 yohimbine, and pentobarbitone (Reed, Sapirstein, Southard & Ogden, 1944) in chronic hypertension, the hypothesis has been presented (Ogden, 1947) that a neurogenic mechanism succeeds the early renal one responsible for hypertension in rats and also in dogs (Mandel, Greene, Sapirstein & Ogden, 1954). Although this view has not been confirmed by others (Nickerson, Bullock & Nomaguchi, 1948;Moss & Wakerlin, 1950) the increased responses to hexaor pentamethonium found in hypertension appear to be in partial agreement with the facts upon which this hypothesis was based, but the change in the sensitivity appears adequate to explain the apparently augmented nervous activity. Although the change in mechanism between hypertension of short and long duration is associated with increased sensitivity to noradrenaline and ganglion block, the fundamental mechanism responsible for the elevated pressure remains a humoral one.…”

Persistent Hypertension in the Dog Following Disruption of the Carotid Sinus Nerves and Subsequent Unilateral Renal Artery Constriction

“…(Table 5) The decrease in mean blood pressure following tetraethylammonium chloride (TEAC) in the combined carotid sinus and unilateral renal hypertensive dogs was similar to that found in normal controls. 11 In 5 control dogs the decrease was -26 mm. Hg, while in 10 combined carotid sinns unilateral renal hypertensive animals the decrease was -23 ram.…”