Role of tigecycline in the control of a carbapenem-resistant Acinetobacter baumannii outbreak in an intensive care unit

Jamal, W.; Salama, Mona F.; Dehrab, N.; Hashem, G. Al; Shahin, M.; Rotimi, V.O.

doi:10.1016/j.jhin.2009.03.023

Cited by 32 publications

(19 citation statements)

References 25 publications

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“…This concern is justified by the phenomenal increase in the resistance rates compared to 1.1% and 0% rates reported from Kuwait in 2009. 5,13 The reason for this jump is not clear at this time but it might be due to sudden high prescription as well as perhaps clonal spread which was not investigated in this study. Further investigation on the genetic relatedness of tigecycline-and colistin-resistant isolates by pulsed-field gel electrophoresis (PFGE) or multilocus sequence technique (MLsT) might be required to detect clonal spread in our hospitals.…”

Section: And Turton Jf Et Al 12 Which Confirmed That This Gene Is Spementioning

confidence: 79%

Emergence of Tigecycline and Colistin Resistance inAcinetobacterSpecies Isolated from Patients in Kuwait Hospitals

Al‐Sweih¹,

Al-Hubail²,

Rotimi³

2011

Journal of Chemotherapy

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The development of resistance is a compelling reason for reviewing administration of antibiotics. Recently, most Acinetobacter infections are caused by multidrug-resistant (MDR) strains which have necessitated the use of tigecycline or colistin. This study was undertaken to determine the susceptibility of Acinetobacter spp. to these and other drugs. A total of 250 Acinetobacter isolates were collected from the 8 government hospitals over a period of 6 months. Susceptibility to 18 antibiotics, including tigecycline and colistin, was investigated by determining their minimum inhibitory concentrations using E test. Of the 250 isolates, 13.6% and 12% were resistant to tigecycline and colistin. A total of 25.2% and 37.2% were resistant to imipenem and meropenem, respectively. Of the 250 isolates 88.4% were MDR. This relatively high prevalence of tigecycline and colistin-resistant isolates indicates an emerging therapeutic problem which may severely compromise the treatment of MDR Acinetobacter spp. infections in Kuwait.

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Section: And Turton Jf Et Al 12 Which Confirmed That This Gene Is Spementioning

confidence: 79%

Emergence of Tigecycline and Colistin Resistance inAcinetobacterSpecies Isolated from Patients in Kuwait Hospitals

Al‐Sweih¹,

Al-Hubail²,

Rotimi³

2011

Journal of Chemotherapy

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“…The majority of the isolates were blood cultures or endotracheal tube secretions, and the Etest showed positive MBL results with all carbapenem-resistant isolates, with two distinct clones being identified (92). However, the type of MBL was not determined.…”

Section: Carbapenem Resistance In P Aeruginosa and Acinetobactermentioning

confidence: 98%

β-Lactamase Production in Key Gram-Negative Pathogen Isolates from the Arabian Peninsula

et al. 2013

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SUMMARY Infections due to Gram-negative bacilli (GNB) are a leading cause of morbidity and mortality worldwide. The extent of antibiotic resistance in GNB in countries of the Gulf Cooperation Council (GCC), namely, Saudi Arabia, United Arab Emirates, Kuwait, Qatar, Oman, and Bahrain, has not been previously reviewed. These countries share a high prevalence of extended-spectrum-β-lactamase (ESBL)- and carbapenemase-producing GNB, most of which are associated with nosocomial infections. Well-known and widespread β-lactamases genes (such as those for CTX-M-15, OXA-48, and NDM-1) have found their way into isolates from the GCC states. However, less common and unique enzymes have also been identified. These include PER-7, GES-11, and PME-1. Several potential risk factors unique to the GCC states may have contributed to the emergence and spread of β-lactamases, including the unnecessary use of antibiotics and the large population of migrant workers, particularly from the Indian subcontinent. It is clear that active surveillance of antimicrobial resistance in the GCC states is urgently needed to address regional interventions that can contain the antimicrobial resistance issue.

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“…Recently, infections due to MDR A. baumannii strains have become a serious problem in some hospitals in Kuwait, particularly the Mubarak Al-Kabeer and Al-Adan hospitals, where these isolates are the second most frequently isolated pathogens, particularly in the ICUs [11]. The Mubarak Al-Kabeer hospital is the primary teaching hospital and serves as both a referral and secondary medical center, whereas Al-Adan hospital, also a teaching hospital, is a secondary medical center, located 16 km away, in the southern part of the country.…”

Section: Introductionmentioning

confidence: 99%

Three distinct clones of carbapenem-resistant Acinetobacter baumannii with high diversity of carbapenemases isolated from patients in two hospitals in Kuwait

Al‐Sweih

Al-Hubail

Rotimi

2012

Journal of Infection and Public Health

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Role of tigecycline in the control of a carbapenem-resistant Acinetobacter baumannii outbreak in an intensive care unit

Cited by 32 publications

References 25 publications

Emergence of Tigecycline and Colistin Resistance inAcinetobacterSpecies Isolated from Patients in Kuwait Hospitals

Emergence of Tigecycline and Colistin Resistance inAcinetobacterSpecies Isolated from Patients in Kuwait Hospitals

β-Lactamase Production in Key Gram-Negative Pathogen Isolates from the Arabian Peninsula

Three distinct clones of carbapenem-resistant Acinetobacter baumannii with high diversity of carbapenemases isolated from patients in two hospitals in Kuwait

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