Role of transcription factor acetylation in the regulation of metabolic homeostasis

Park, Joo-Man; Jo, Seongho; Kim, Miyoung; Kim, Tae Hyun; Ahn, Young Soo

doi:10.1007/s13238-015-0204-y

Cited by 53 publications

(51 citation statements)

References 92 publications

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“…6) (22,70). Similar regulatory functions are attributed to post-translational lysine acetylation (102,123). Of particular relevance to the induction of innate immune memory for its potential influence on cellular metabolism is the post-translational methylation recently shown to regulate HIF1a function.…”

Section: Multiple Roles For Lysine Methylation In Innate Immune Memorymentioning

confidence: 91%

Epigenetics and Trained Immunity

Heijden

Noz

Joosten

et al. 2018

Antioxidants & Redox Signaling

198

170

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Section: Multiple Roles For Lysine Methylation In Innate Immune Memorymentioning

confidence: 91%

Epigenetics and Trained Immunity

Heijden

Noz

Joosten

et al. 2018

Antioxidants & Redox Signaling

198

170

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“…Overexpressed [26] FOXK2 Under-expressed [27] HIC1 Under-expressed [28] CHK1 Ubiquitination Overexpressed [29] p53 Under-expressed [30] Acetylation Acetylation has emerged as a dynamic post translational modification that plays a key role in regulating nuclear transcription and metabolic homeostasis [33]. [40].…”

Section: Sumoylationmentioning

confidence: 99%

Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview

Sharma¹,

Prabhakaran²,

Desai³

et al. 2019

Oncogen

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Studies on post-translational modifications (PTMs) have grabbed attention of the scientific community worldwide, its role in pathogenesis of cancer and prognostic biomarkers associated with cancers. However, unraveling the specific role of PTMs in carcinogenesis or in predictive biomarkers requires holistic understanding of the cancer types and associated mechanisms. Manifestation of cancer is complex and involves multiple steps including modifications at the levels of genes, associated proteins and signaling pathways. Biomarkers, as a prognostic marker, are critical in deciding efficacy of the clinical outcomes in malignancies. Growing evidence suggests that several biomarkers that are post-translationally modified play important role in human cancers. In the current review, few of such biomarkers and targets that are post-translationally modified and are associated with carcinogenesis are collated and analyzed to provide a bird's eye view of their role in cancer types. Such analysis will help in understanding the pathogenesis and the precise role of biomarkers in designing better therapeutic interventions for different cancer types. METHODS The writing of this review involved a comprehensive search of original articles and reviews published on the subject of post translational modifications. Free search engine PubMed was used to conduct the online search. Sorting option 'Best Match' of PubMed was used to conduct the more relevant search.Various expressions were used to find relevant references for example, "post translational modifications in cancer", "acetylation in cancer and post translational modifications", "methylation in cancer and post translational modifications", "biomarkers in cancer" etc. Some other expressions were used to conduct a more specific search to complement the findings in the articles retrieved with the more general search criteria for example, "checkpoint kinase 1 in cancer", "candidate tumor suppressor BTG3" etc. Further, some articles were also found through reading of previous reviews on similar subjects including the ones by Karve and Cheema [1], and Han et al, [2].Articles clearly related to the theme of this review and those that matched the search criteria were selected according to their year of publication (only articles published after

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“…Acetylation has also been reported to modify the activity of TFs, thereby regulating the ability of the TF to bind DNA (Gu & Roeder, 1997;reviewed in Kouzarides, 2000;Bannister & Miska, 2000). Besides histones, HATs and HDACs, respectively acetylate and deacetylate non-histone proteins, including TFs, which may suggest a mechanism for SCR acetylation/deacetylation (reviewed in Park et al, 2015;Wang et al, 2011;Glozak et al, 2005;Choudhary et al, 2014).…”

Section: Competition Of Acetylation and Formylation Observed In Scrmentioning

confidence: 99%

Post-translational modifications ofDrosophila melanogasterHOX protein, Sex combs reduced

Banerjee

Percival‐Smith

2019

Preprint

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Homeotic selector (HOX) transcription factors (TFs) regulate gene expression that determines the identity of Drosophila body segments along the anterior-posterior (A-P) axis. Besides a highly conserved DNA-binding homeodomain (HD), HOX proteins also contain functionally important, evolutionarily conserved small motifs, which may be Short Linear Motifs (SLiMs). SLiMs are proposed to be sites of phosphorylation and this may regulate the activity of HOX proteins. Sex combs reduced protein fused to a triple tag (SCRTT) was extracted from developing embryos that express SCRTT from a heat-shock promoter fusion gene and purified using Ni-NTA beads under denaturing conditions. Multiple sites of post-translational modification (PTM) were identified in purified SCRTT

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Role of transcription factor acetylation in the regulation of metabolic homeostasis

Cited by 53 publications

References 92 publications

Epigenetics and Trained Immunity

Epigenetics and Trained Immunity

Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview

Post-translational modifications ofDrosophila melanogasterHOX protein, Sex combs reduced

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