Role of Type IV Collagen in Prolactin Release from Anterior Pituitaries of Male Rats

Díaz, Emilce S.; Rettori, Valéria; Suescun, María Olga; Lustig, Livia; McCann, Samuel M.; Denduchis, Berta

doi:10.1385/endo:18:2:185

Cited by 3 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it has been shown that laminin controls the release of prolactin and gonadotropins in the normal pituitary (27). Collagen IV has also been shown to control the release of prolactin (28).…”

Section: The Pituitary Glandmentioning

confidence: 99%

Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix

Páez-Pereda

Kuchenbauer

Arzt

et al. 2005

Braz J Med Biol Res

View full text Add to dashboard Cite

The extracellular matrix is a three-dimensional network of proteins, glycosaminoglycans and other macromolecules. It has a structural support function as well as a role in cell adhesion, migration, proliferation, differentiation, and survival. The extracellular matrix conveys signals through membrane receptors called integrins and plays an important role in pituitary physiology and tumorigenesis. There is a differential expression of extracellular matrix components and integrins during the pituitary development in the embryo and during tumorigenesis in the adult. Different extracellular matrix components regulate adrenocorticotropin at the level of the proopiomelanocortin gene transcription. The extracellular matrix also controls the proliferation of adrenocorticotropin-secreting tumor cells. On the other hand, laminin regulates the production of prolactin. Laminin has a dynamic pattern of expression during prolactinoma development with lower levels in the early pituitary hyperplasia and a strong reduction in fully grown prolactinomas. Therefore, the expression of extracellular matrix components plays a role in pituitary tumorigenesis. On the other hand, the remodeling of the extracellular matrix affects pituitary cell proliferation. Matrix metalloproteinase activity is very high in all types of human pituitary adenomas. Matrix metalloproteinase secreted by pituitary cells can release growth factors from the extracellular matrix that, in turn, control pituitary cell proliferation and hormone secretion. In summary, the differential expression of extracellular matrix components, integrins and matrix metalloproteinase contributes to the control of pituitary hormone production and cell proliferation during tumorigenesis.

show abstract

Section: The Pituitary Glandmentioning

confidence: 99%

Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix

Páez-Pereda

Kuchenbauer

Arzt

et al. 2005

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…In addition, the anterior pituitary cells construct a unique topography by means of homophilic and heterophilic affinities between cell types (Noda et al 2001), and by differential affinities to the ECM types (Denduchis et al 1994, Diaz et al 2002. The functions of hormone-producing cells are mainly regulated by endocrine, autocrine, and paracrine signaling.…”

Section: Introductionmentioning

confidence: 99%

Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells

Horiguchi¹,

Kikuchi²,

Kusumoto³

et al. 2009

Journal of Endocrinology

View full text Add to dashboard Cite

Folliculo-stellate (FS) cells in the anterior pituitary gland appear to possess multifunctional properties. Recently, the development of transgenic rats (S100b-green fluorescent protein (GFP) rats) that express GFP specifically in FS cells in the anterior pituitary gland has allowed us to distinguish and observe living FS cells in other kinds of pituitary cells. We used S100b-GFP rats to investigate the topographic affinity of FS cells for other pituitary cells. We observed living FS cells in enzymatically dispersed anterior pituitary cells of S100b-GFP rats under a fluorescent microscope, and noted that FS cells markedly extended and contracted cytoplasmic processes and formed interconnections with neighboring FS cells. In addition, FS cells adhered to small clusters of GFPnegative cells, which were primarily hormone-producing cells, and these clusters further aggregated during the course of cytoplasmic contraction. In the presence of laminin, fibronectin, and varying types of collagen, FS cells showed marked changes in shape and specific proliferative activity; however, GFP-negative cells did not. On reverse transcription-PCR analysis and immunohistochemistry, FS cells were shown to express integrin subunits, which are the cell surface receptors for extracellular matrix (ECM). In the anterior pituitary gland, FS cells and the various types of hormoneproducing cells generate a unique topography in the presence of basement membrane components and interstitial collagens. The novel characteristics of FS cells observed in the present study suggest that in the anterior pituitary gland, FS cells play important roles in determining and/or maintaining local cellular arrangement in the presence of ECM components.

show abstract

“…Pituitary cells also express integrins (11). There is increasing evidence that ECM is critical for development and differentiation of the pituitary gland (12), for postnatal cell migration and pituitary remodeling (13), and for hormone secretion (14, 15). As in other tissues, ECM molecules may also have important roles in pituitary tumorigenesis (16).…”

Section: Introductionmentioning

confidence: 99%

Distinct Expression Patterns of Osteopontin and Dentin Matrix Protein 1 Genes in Pituitary Gonadotrophs

et al. 2019

View full text Add to dashboard Cite

Cell-matrix interactions play important roles in pituitary development, physiology, and pathogenesis. In other tissues, a family of non-collagenous proteins, termed SIBLINGs, are known to contribute to cell-matrix interactions. Anterior pituitary gland expresses two SIBLING genes, Dmp1 (dentin matrix protein-1) and Spp1 (secreted phosphoprotein-1) encoding DMP1 and osteopontin proteins, respectively, but their expression pattern and roles in pituitary functions have not been clarified. Here we provide novel evidence supporting the conclusion that Spp1/ osteopontin, like Dmp1 /DMP1, are expressed in gonadotrophs in a sex- and age-specific manner. Other anterior pituitary cell types do not express these genes. In contrast to Dmp1, Spp1 expression is higher in males; in females, the expression reaches the peak during the diestrus phase of estrous cycle. In further contrast to Dmp1 and marker genes for gonadotrophs, the expression of Spp1 is not regulated by gonadotropin-releasing hormone in vivo and in vitro . However, Spp1 expression increases progressively after pituitary cell dispersion in both female and male cultures. We may speculate that gonadotrophs signal to other pituitary cell types about changes in the structure of pituitary cell-matrix network by osteopontin, a function consistent with the role of this secretory protein in postnatal tissue remodeling, extracellular matrix reorganization after injury, and tumorigenesis.

show abstract

Role of Type IV Collagen in Prolactin Release from Anterior Pituitaries of Male Rats

Cited by 3 publications

References 24 publications

Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix

Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix

Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells

Distinct Expression Patterns of Osteopontin and Dentin Matrix Protein 1 Genes in Pituitary Gonadotrophs

Contact Info

Product

Resources

About