Role of Vitamin D Glucosiduronate in Calcium Homeostasis

Nagubandi, Sreeramulu; Kumar, Rajiv; Londowski, James M.; Corradino, R. A.; Tietz, Pamela S.

doi:10.1172/jci109979

Cited by 32 publications

(10 citation statements)

References 14 publications

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“…There was significantly higher hydroxyestrone sulfate in obese men compared with normal-weight men in this study. Vitamin D3 glucosiduronate plays an important role in calcium homeostasis through the hydrolysis of the conjugate to vitamin D(3), which showed the reutilization of the biliary products of vitamin D(3) (Nagubandi et al, 1980). In addition, higher concentrations of estrone from extraglandular conversion of plasma androstenedione may result in feminization (Hemsell et al, 1997).…”

Section: Principal Changes In Metabolites Of Obesity With Hyperlipemiamentioning

confidence: 99%

Metabolomic analysis of serum from obese adults with hyperlipemia by UHPLC‐Q‐TOF MS/MS

Wang

Liu

et al. 2015

Biomedical Chromatography

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The prevalence of obesity has dramatically increased and poses a major threat to human health. Obesity often accompanies hyperlipemia, which is strongly related to the occurrence and development of obesity-related chronic diseases. Differences in metabolomic profiling of serum between obese (with hyperlipemia) and normal-weight men (n = 30 in each group) were investigated using ultrahigh-pressure liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF MS/MS) and partial least-squares-discriminant analysis (PLS-DA). Obese men showed higher levels of weight, body mass index, fat mass, systolic blood pressure, fasting plasma glucose, triglyeride, total cholesterol, insulin, HOMA-IR and high-sensitivity CRP. Obese and normal-weight groups were clearly discriminated from each other on a PLS-DA score plot and nine major metabolites contributing to the discrimination were assigned, including increased 2-octenoylcarnitine, eicosadienoic acid, 12-hydroperoxyeicosatetraenoic acid, 4-hydroxyestrone sulfate, lysoPE[18:1(11Z)/0:0], thromboxane B2 and pyridinoline and decreased vitamin D3 glucosiduronate and 9,10-DHOME. These metabolites were associated with lipid metabolism and obesity-related diseases, and reflected the metabolic differences between normal and obese men, which may be important for future clinical diagnosis, treatment and assessment of the therapeutic effect on obesity-related chronic disease.

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Section: Principal Changes In Metabolites Of Obesity With Hyperlipemiamentioning

confidence: 99%

Metabolomic analysis of serum from obese adults with hyperlipemia by UHPLC‐Q‐TOF MS/MS

Wang

Liu

et al. 2015

Biomedical Chromatography

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“…Sodium concentrations were measured in urine using an Instrumentation Laboratory flame photometer (Instrumentation Laboratory, Wilmington, Massachusetts, USA). Serum and urine calcium concentrations were determined by atomic absorption spectrometry (26)(27)(28)(29). Plasma 1α, 25-dihydroxyvitamin D and 25-hydroxyvitamin D concentrations were measured by and sodium-dependent phosphate, alanine, and glucose cotransport measured as described previously (2,12).…”

Section: Synthesis and Purification Of Sfrp-4mentioning

confidence: 99%

Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent

Berndt¹,

Craig²,

Bowe³

et al. 2003

J. Clin. Invest.

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266

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Conflict of interest:The authors have declared that no conflict of interest exists. Nonstandard abbreviations used: tumor-induced osteomalacia (TIO); parathyroid hormone (PTH); parathyroid hormonerelated protein (PTHrP); opossum kidney (OK); serial analysis of gene expression (SAGE); secreted frizzled-related protein-4 (sFRP-4); mean arterial blood pressure (MAP); thyro-parathyroidectomized (TPTX); phosphate diet (Pi); fractional excretion of phosphate (FEPi); fractional sodium excretion (FENa); fractional excretion of calcium (FECa); X-linked hypophosphatemic rickets (XLH); autosomal dominant hypophosphatemic rickets (ADHR).

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“…1,25-(OH) 2 D 3 is extensively metabolized in the liver accomplished via several catabolic routes, with 24-hydroxylation initiating the apparent pathway for the elimination of the hormone [22][23][24]. We hypothesised that a clinically significant hepatic first pass effect may exist upon the administration of 1,25-(OH) 2 D 3 as a hepatic arterial infusion, and that such an effect may allow high levels of 1,25-(OH) 2 D 3 to be delivered to the liver and consequently the liver tumor whilst avoiding high systemic levels.…”

Section: 25-(oh) 2 D 3 Undergoes Extensive First Pass Metabolism Inmentioning

confidence: 99%

1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

Pourgholami

Morris

2004

The Journal of Steroid Biochemistry and Molecular Biology

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Role of Vitamin D Glucosiduronate in Calcium Homeostasis

Abstract: A B S T R A C T Evidence has beenThese results suggest the existence of a mechanism for reutilization of the biliary products of vitamin D3.

Cited by 32 publications

References 14 publications

Metabolomic analysis of serum from obese adults with hyperlipemia by UHPLC‐Q‐TOF MS/MS

Metabolomic analysis of serum from obese adults with hyperlipemia by UHPLC‐Q‐TOF MS/MS

Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent

1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

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