Role of vitamin D levels and vitamin D receptor polymorphisms in relation to coronary artery disease

Shanker, Jayashree; Maitra, Arindam; Arvind, Prathima; Nair, Jiny; Dash, Debabratha; Manchiganti, Rushiraj; Rao, Veena S.; Radhika, Kasi N.; Hebbagodi, Sridhar; Kakkar, Vijay V.

doi:10.1097/mca.0b013e3283472a57

Cited by 32 publications

(22 citation statements)

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“…Ortlepp et al determined an association between the G/G genotype of VDR gene BsmI polymorphism and the risk of myocardial infarction in patients under the age of 65 [31]. The contradictory data were obtained by Shanker et al [32] and Pan et al [33] -they detected no association between polymorphic variants and haplotypes of the VDR gene and the development of coronary heart disease. Porojan et al examined the relation of VKORC1 allelic polymorphisms with atherosclerosis and calci- fi cation.…”

Section: Resultsmentioning

confidence: 86%

Association of allelic polymorphisms of the Matrix Gla-protein system genes with acute coronary syndrome in the Ukrainian population

et al. 2015

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Section: Resultsmentioning

confidence: 86%

Association of allelic polymorphisms of the Matrix Gla-protein system genes with acute coronary syndrome in the Ukrainian population

et al. 2015

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“…In the Korean Longitudinal Study on Health and Aging [17], low 25-OH vitamin D levels were associated with an increased prevalence of a more than 50% coronary artery stenosis as determined by cardiac CTA. In two separate Indian studies of individuals with angiographically proven coronary artery disease [19,20], those with vitamin D deficiency had a significantly higher prevalence of coronary artery stenoses. In contrast to these findings, in the previously mentioned Danish crosssectional study of type II diabetics with an elevated urinary albumin excretion rate [13], neither moderate (5.0-10.0 ng/ml) nor insufficient (10.0-20.0 ng/ml) vitamin D levels were significantly associated with an increased prevalence of significant coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Low 25-OH vitamin D levels are not associated with coronary artery calcium or obstructive stenoses

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Barlow

et al. 2015

Coronary Artery Disease

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“…Numerous studies have demonstrated the involvement of these biological processes in atherosclerosis. Abnormal vascular smooth muscle cell proliferation has been shown to increase the production of acute-phase reactant proteins like CRP, while Vitamin D deficiency has been implicated in cardiovascular disease [70]–[72]. Both TLR and NLR signaling pathways belong to a specific family of pattern recognition receptors that trigger the expression of several genes involved in innate immune response [73].…”

Section: Discussionmentioning

confidence: 99%

Network Analysis of Inflammatory Genes and Their Transcriptional Regulators in Coronary Artery Disease

et al. 2014

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Network analysis is a novel method to understand the complex pathogenesis of inflammation-driven atherosclerosis. Using this approach, we attempted to identify key inflammatory genes and their core transcriptional regulators in coronary artery disease (CAD). Initially, we obtained 124 candidate genes associated with inflammation and CAD using Polysearch and CADgene database for which protein-protein interaction network was generated using STRING 9.0 (Search Tool for the Retrieval of Interacting Genes) and visualized using Cytoscape v 2.8.3. Based on betweenness centrality (BC) and node degree as key topological parameters, we identified interleukin-6 (IL-6), vascular endothelial growth factor A (VEGFA), interleukin-1 beta (IL-1B), tumor necrosis factor (TNF) and prostaglandin-endoperoxide synthase 2 (PTGS2) as hub nodes. The backbone network constructed with these five hub genes showed 111 nodes connected via 348 edges, with IL-6 having the largest degree and highest BC. Nuclear factor kappa B1 (NFKB1), signal transducer and activator of transcription 3 (STAT3) and JUN were identified as the three core transcription factors from the regulatory network derived using MatInspector. For the purpose of validation of the hub genes, 97 test networks were constructed, which revealed the accuracy of the backbone network to be 0.7763 while the frequency of the hub nodes remained largely unaltered. Pathway enrichment analysis with ClueGO, KEGG and REACTOME showed significant enrichment of six validated CAD pathways - smooth muscle cell proliferation, acute-phase response, calcidiol 1-monooxygenase activity, toll-like receptor signaling, NOD-like receptor signaling and adipocytokine signaling pathways. Experimental verification of the above findings in 64 cases and 64 controls showed increased expression of the five candidate genes and the three transcription factors in the cases relative to the controls (p<0.05). Thus, analysis of complex networks aid in the prioritization of genes and their transcriptional regulators in complex diseases.

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Role of vitamin D levels and vitamin D receptor polymorphisms in relation to coronary artery disease

Abstract: Low vitamin D level was associated with an enhanced risk for incident CAD. VDR genotypes did not show any association with either vitamin D levels or CAD.

Cited by 32 publications

References 42 publications

Association of allelic polymorphisms of the Matrix Gla-protein system genes with acute coronary syndrome in the Ukrainian population

Association of allelic polymorphisms of the Matrix Gla-protein system genes with acute coronary syndrome in the Ukrainian population

Low 25-OH vitamin D levels are not associated with coronary artery calcium or obstructive stenoses

Network Analysis of Inflammatory Genes and Their Transcriptional Regulators in Coronary Artery Disease

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