Role of vitamin D supplementation in allergic rhinitis

Modh, Datt; Katarkar, Ashish; Thakkar, Bhaskar; Jain, Anil K.; Shah, Pankaj; Joshi, Krupal

doi:10.4103/0972-6691.134223

Cited by 23 publications

(15 citation statements)

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“…Absolute Eosinophils counts (AEC) were significantly raised in the allergic cases as shown in The findings of present study are in agreement with previous studies. 11,12 The findings are of clinical importance as the vitamin D 3 deficiency if treated timely may positively benefit the URTA related morbidities.…”

Section: Resultsmentioning

confidence: 97%

Upper Respiratory Tract Allergy

Qureshi

Palli

2018

TPMJ

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Objectives: To evaluate serum vitamin D3, Blood Eosinophils, AbsoluteEosinophils Counts and IgE in the upper respiratory tract allergies (URTA) in Rural PopulationSindh. Study Design: Case control study. Place and Duration: Department of Medicine andBiochemistry, Isra University from January 2014 to October 2015. Subjects & Methods: Asample of 50 diagnosed cases of URTA and 50 age and gender matched control subjects wereselected through non-probability sampling. Blood samples were centrifuged to separate sera.Serum vitamin D3, Blood Eosinophils, Absolute Eosinophils and serum IgE were estimated.Data was analyzed on the SPSS 22.0 software at 95% confidence interval (P≤0.05). Results:Vitamin D3 showed significant decrease in allergic subjects; noted as 26.96±9.75 ng/dlcompared to 32.62±11.75 ng/dl in controls. Blood Eosinophils (%) were raised in the allergicsubjects compared to controls 3.42±1.91 and 1.93±0.65 respectively (p=0.0001). AbsoluteEosinophils counts (AEC) were significantly raised in the allergic cases as shown in Table-I(p=0.0001). Serum IgE in controls and cases was noted as 86.7±17.39 and 400.26±232.8IU/ml respectively (p=0.0001). Conclusion: The present study reports vitamin D3 deficiencyassociated with raised Eosinophils, Absolute Eosinophils counts and serum IgE in upperrespiratory tract allergy.

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Section: Resultsmentioning

confidence: 97%

Upper Respiratory Tract Allergy

Qureshi

Palli

2018

TPMJ

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“…The authors reported that patients in the allergic rhinitis group were vitamin D deficient, but none of the subjects in the control group were vitamin D deficient. In recent decades, some studies have suggested a relationship between the increasing incidence of allergic disease and vitamin D deficiency; however, these findings are still debated [15] [16]. A meta-analysis conducted by Kim et al found that prior vitamin D levels were not associated with developing allergic rhinitis but were associated with the prevalence of allergic rhinitis in children [17].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis

Sudiro¹,

Lestari²,

Madiadipoera³

et al. 2017

OALib

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Background: Vitamin D deficiency has been targeted as a cause of the increased incidence of allergic rhinitis. Many factors, including sun exposure, influence vitamin D levels. Indonesia is a country with abundant sunshine exposure throughout the year; therefore, Indonesian residents are not expected to have inadequate vitamin D levels. Objective: This study aimed to investigate whether vitamin D deficiency levels are correlated with disease spectrum among allergic rhinitis patients. Material and Method: A cross-sectional study was conducted in the Rhino-Allergy ORL-HNS Clinic at Dr. Hasan Sadikin General Hospital in Bandung, Indonesia, from March-June 2016. All subjects underwent skin prick tests and serum 25-hydroxy vitamin D levels examination. To measure the association between vitamin D deficiency level and severity of allergic rhinitis, a Rank-Spearman correlation test was used and significant level was determined when the p-value is <0.05. Results: A total of 46 allergic rhinitis patients (19 males, 27 females, aged 28.3 ± 6 years) were included in this study. 63% of allergic rhinitis patients had a severe vitamin D deficiency and 50% of them classified as having persistent moderate-severe based on ARIA-WHO classification. Vitamin D deficiency was found to be significantly correlated with severity of allergic rhinitis status (r s = −0.321; p = 0.005). Conclusion: We found vitamin D deficiency was correlated with allergic rhinitis classification and a significant proportion of allergic rhinitis patients showed a severe vitamin D deficiency.

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“…Vitamin D can regulate the body’s immune cells which work on the pathophysiology of AR. Previous research in India discovered that there was vitamin D deficiency in 91% of AR samples; however, the incidence of vitamin D deficiency in AR in Indonesia has not been found yet [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Serum Vitamin D Levels with Allergic Rhinitis Incidence and Total Nasal Symptom Score in Allergic Rhinitis Patients

Restimulia¹,

Pawarti²,

Ekorini³

2018

Open Access Maced J Med Sci

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BACKGROUND:Allergic diseases and vitamin D deficiency were found to have a relationship. However, there was limited number of studies on the relationship between vitamin D with allergic rhinitis (AR) and total nasal symptom scores (TNSS), particularly in determining the cut-off points of serum vitamin D levels which correlated to AR.AIM:As this particular study has never been conducted in Indonesia, the main objective of this study was to investigate this issue.METHODS:The research was conducted at Dr Soetomo Hospital, Surabaya in January 2017. A group of 30 subjects were recruited using consecutive sampling. Levels of serum vitamin D were measured using electrochemiluminescence immunoassay (ECLIA) method while the total nasal symptom scores were obtained by accumulating all the nasal symptoms. Data of serum vitamin D levels and TNSS were analysed statistically with the Pearson correlation test.RESULTS:It was found that the mean of serum 25(OH) vitamin D levels (9.13 ng/mL) of the AR group was significantly lower than the non-AR group (26.22 ng/mL) (P = 0.000). The vitamin D cut-off points which correlated to AR was about 12.83 ng/mL (sensitivity = 80%; specificity = 100%). A Pearson correlation test found a strong, negative correlation between vitamin D levels and TNSS (P = 0.000; r = -0.800).CONCLUSION:There was a strong, negative correlation between serum vitamin D levels with AR and TNSS. The cut-off points of serum vitamin D levels correlated to AR were approximately12.83 ng/mL. Thus, further research needs to be conducted.

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Role of vitamin D supplementation in allergic rhinitis

Cited by 23 publications

References 0 publications

Upper Respiratory Tract Allergy

Upper Respiratory Tract Allergy

Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis

The Relationship between Serum Vitamin D Levels with Allergic Rhinitis Incidence and Total Nasal Symptom Score in Allergic Rhinitis Patients

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