Roles of ligands from the TNF superfamily in B cell development, function, and regulation

Figgett, William A.; Vincent, Fabien B.; Saulep-Easton, Damien; Mackay, Fabienne

doi:10.1016/j.smim.2014.06.001

Cited by 28 publications

(22 citation statements)

References 172 publications

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“…This receptor is a member of the TNF superfamily and is one of the three receptors for the B‐cell‐activating factor from the TNF family (BAFF). Upon binding to the BAFF receptor, BAFF induces naïve B‐cell survival and maturation; while via the B‐cell maturation antigen, BAFF supports the survival of plasma cells in the bone marrow 35 …”

Section: Discussionmentioning

confidence: 99%

“…Upon binding to the BAFF receptor, BAFF induces naïve B-cell survival and maturation; while via the B-cell maturation antigen, BAFF supports the survival of plasma cells in the bone marrow. 35 Extensive work was necessary to clarify the more elusive role of TACI, revealing two sides of this receptor: a positive function driving T-cell-independent humoral immune responses 36 and a negative one downregulating B-cell activation and expansion by triggering FAS-mediated B-cell apoptosis. 21 It is also known that an endogenous soluble TACI form exists in vivo and that its shedding is due to the proteolytic activity of the metalloproteinase ADAM10, releasing this receptor from the membrane of activated memory B cells.…”

Section: Discussionmentioning

confidence: 99%

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Interferon‐β therapy specifically reduces pathogenic memory B cells in multiple sclerosis patients by inducing a FAS‐mediated apoptosis

Rizzo

Giacomini

Mechelli³

et al. 2016

Immunol Cell Biol

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Growing evidences put B lymphocytes on a central stage in multiple sclerosis (MS) immunopathology. While investigating the effects of interferon-β (IFN-β) therapy, one of the most used first-line disease-modifying drugs for the treatment of relapsing-remitting MS, in circulating B-cell sub-populations, we found a specific and marked decrease of CD27 memory B cells. Interestingly, memory B cells are considered a population with a great disease-driving relevance in MS and resulted to be also target of B-cell depleting therapies. In addition, Epstein-Barr virus (EBV), associated with MS etiopathogenesis, harbors in this cell type and an IFN-β-induced reduction of the memory B-cell compartment, in turn, resulted in a decreased expression of the EBV gene latent membrane protein 2A in treated patients. We found that in vivo IFN-β therapy specifically and highly induced apoptosis in memory B cells, in accordance with a strong increase of the apoptotic markers Annexin-V and active caspase-3, via a mechanism requiring the FAS-receptor/TACI (transmembrane activator and CAML interactor) signaling. Thus, efficacy of IFN-β therapy in MS may rely not only on its recognized anti-inflammatory activities but also on the specific depletion of memory B cells, considered to be a pathogenic cell subset, reducing their inflammatory impact in target organs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interferon‐β therapy specifically reduces pathogenic memory B cells in multiple sclerosis patients by inducing a FAS‐mediated apoptosis

Rizzo

Giacomini

Mechelli³

et al. 2016

Immunol Cell Biol

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“…With respect to the latter, most TNF superfamily members play essential roles in different aspects of B cell biology, from their development in hematopoietic tissues, to their maturation in peripheral tissues and their differentiation into memory or plasma cells [2]. Interestingly, cooperative signaling via TNF ligands and receptors was first seen within the CD40-CD40 ligand (CD40L) interaction, that promotes the proliferation of antigen-activated B cells through the expression of CD40L by CD4 + T helper (Th) cells [3].…”

Section: Introductionmentioning

confidence: 99%

Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease

et al. 2017

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Proliferative kidney disease (PKD) is a parasitic infection of salmonid fish characterized by hyper-secretion of immunoglobulins in response to the presence of the myxozoan parasite, Tetracapsuloides bryosalmonae. In this context, we hypothesized that the BAFF/APRIL axis, known to play a major role in B cell differentiation and survival in mammals, could be affected by the parasite and consequently be involved in the apparent shift in normal B cell activity. To regulate B cell activity, BAFF and APRIL bind to transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), whereas BAFF also binds to BAFF receptor (BAFF-R). In teleost fish, although some BAFF and APRIL sequences have been reported, their receptors have not been identified. Thus, as a first step in the current work, we have identified homologues to mammalian TACI, BCMA and BAFF-R in rainbow trout (Oncorhynchus mykiss), that constitute the first report of BAFF and APRIL receptor sequences in fish. Subsequently we studied the transcriptional modulation of BAFF, APRIL, and the fish-specific related cytokine, BALM and their putative receptors in fish naturally exposed to T. bryosalmonae. Finally, to gain further insights on the functional role that these cytokines play during the course of PKD, we have studied their effect on the survival of kidney IgM+ B cells and on immunoglobulin transcription. Our results support the premise that the BAFF / APRIL axis could play an important role during PKD, which may open the possibility of new therapeutic treatments against the disease.

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“…BCMA is mostly expressed on plasma cells (PC) and is important for their survival, essentially in response to a proliferation-inducing ligand (APRIL; also named TNFSF13), which binds to TACI and BCMA (reviewed in Ref. [9]). TACI is expressed on mature B cells, and most highly on MZ and peritoneal B-1 B cells in mice; TACI is expressed most highly on CD19 þ /CD27 þ memory B cells in humans [10,11].…”

Section: Introductionmentioning

confidence: 99%

Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers

Figgett

Deliyanti

Fairfax

et al. 2015

Journal of Autoimmunity

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Roles of ligands from the TNF superfamily in B cell development, function, and regulation

Cited by 28 publications

References 172 publications

Interferon‐β therapy specifically reduces pathogenic memory B cells in multiple sclerosis patients by inducing a FAS‐mediated apoptosis

Interferon‐β therapy specifically reduces pathogenic memory B cells in multiple sclerosis patients by inducing a FAS‐mediated apoptosis

Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease

Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers

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