Roles of secretory leukocyte protease inhibitor amniotic membrane in oral wound healing

Abstract

Secretory Leukocyte Protease Inhibitor (SLPI) is serine protease inhibitor. Secretory Leukocyte Protease Inhibitor is a protein found in secretions such as whole saliva, seminal fluid, cervical mucus, synovial fluid, breast milk, tears, and cerebral spinal fluid, as in secretions from the nose and bronchi, amniotic fluid and amniotic membrane etc. These findings demonstrate that SLPI function as a potent anti protease, anti inflammatory, bactericidal, antifungal, tissue repair, extra cellular synthesis. Impaired healing states are characterized by excessive proteolysis and often bacterial infection, leading to the hypothesis that SLPI may have a role in the process. The objectives of this article are to investigate the role of SLPI in oral inflammation and how it contributes to tissue repair in oral mucosa. The oral wound healing responses are impaired in the SLPI sufficient mice and matrix synthesis and collagen deposition are delayed. This study indicated that SLPI is a povital factor necessary for optimal wound healing.

Secretory leukocyte protease inhibitor and its role in virus induced head and neck cancers

“…Gen SLPI je lokalizovan na hromozomu 20q12-13.2 2 . Ima različite imunološke sposobnosti koje uključuju njegovu antiinflamatornu i antimikrobnu aktivnost 3 . Zbog svoje antiproteazne aktivnosti, može inhibirati virusne infekcije 4 .…”

“…SLPI was first identified in secretions from patients with chronic obstructive pulmonary disease (COPD) and cystic fibrosis and was considered as an antielastase inhibitor 2 . It is produced from varied cells of the body including neutrophils, macrophages, β-cells of the pancreas, epithelium of renal tubules, acinar cells of major salivary and submucosal glands as well as mucous membranes of respiratory and gastrointestinal tracts 2,3 . In the oral cavity, it was first identified in parotid secretions but since then has been isolated from almost all human secretions including seminal, cervical, cere-brospinal, synovial, nasal, bronchial as well as from breast milk and tears 2,3 .…”

“…Smanjeni SLPI je povezan sa produženim vremenom zarastanja. Ova funkcija SLPI u promovisanju zarastanja rana je verovatno posledica njegove anti-inflamatorne aktivnosti koja dovodi do brže formacije matriksa u ranama 3,6 .…”

“…The decreased SLPI was associated with the increased time of healing. This function of SLPI in promoting wound healing is probably a consequence of its anti-inflammatory activity leading to faster matrix formation in wounds 3,6 .…”

“…The SLPI gene is localized on chromosome 20q12-13.2 2 . It has a variety of immunological capabilities, which include its anti-inflammatory and anti-microbial activity 3 . Due to its anti-protease activity, it can inhibit viral infections 4 .…”