Sponge amnion potential in post tooth extraction wound healing by interleukin-6 and bone morphogenetic protein-2 expression analysis: An animal study

Indrawati, Dwi Wahyu; Munadziroh, Elly; Sulisetyawati, Theresia Indah Budhy; Fadhlallah, Prasiddha Mahardhika El

doi:10.4103/1735-3327.266089

Dent Res J

2019

DOI: 10.4103/1735-3327.266089

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Sponge amnion potential in post tooth extraction wound healing by interleukin-6 and bone morphogenetic protein-2 expression analysis: An animal study

Dwi Wahyu Indrawati

Elly Munadziroh

Theresia Indah Budhy Sulisetyawati

et al.

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Cited by 4 publications

References 19 publications

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Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts

Mahmoud,

Hamad,

Al Shibitini

et al. 2024

ACS Pharmacol. Transl. Sci.

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Understanding the complex interplay of pro-inflammatory and anti-inflammatory cytokines is crucial in the field of wound healing, as it holds the key to developing effective therapeutics. In the initial stages of wound healing, pro-inflammatory cytokines like IL-1β, IL-6, TNF-α, and various chemokines play vital roles in recruiting cells for debris clearance and the recruitment of growth factors. Careful regulation and timely resolution of this early inflammation are essential for optimal wound repair. As the healing process progresses, anti-inflammatory proteins such as IL-10 and IL-4 become instrumental in facilitating the transition to later stages where proinflammatory cytokines promote angiogenesis and wound remodeling. This Perspective underscores the complexity of inflammatory cytokines in wound healing research and emphasizes the need for comprehensive and unbiased methodologies in their evaluation. For robust and reliable results in wound-healing research, a more holistic approach is necessary�one that considers the roles, interactions, and timing of biological molecules, alongside careful sampling and evaluation strategies.

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Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts

Mahmoud,

Hamad,

Al Shibitini

et al. 2024

ACS Pharmacol. Transl. Sci.

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The Role of Recombinant Secretory Leukocyte Protease Inhibitor to CD163, FGF-2, IL-1 and IL-6 Expression in Skin Wound Healing

Munadziroh¹,

Putri²,

Ristiana³

et al. 2022

CCID

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Background The wound healing process can be optimized through the addition of a biomaterial such as recombinant secretory leukocyte protease inhibitor (rSLPI). The SLPI is a non-glycosylated proteomic material that inhibits protease enzymes and has anti-inflammatory properties, thus accelerating wound healing. This study analyzed the administration of rSLPI doses 0.04 cc and 0.06 cc in skin wound healing on the CD163 expression of macrophages and cytokines such as interleukin 1 (IL-1), interleukin 6 (IL-6) and fibroblast growth factor 2 (FGF-2). Materials and Methods rSLPI produced from Escherichia coli TOP10 as the cloning host, BL21 (DE3) strains as the expression host and pET30a plasmids were used for the expression system construction. The wound was created on Wistar rat dorsal skin, then rSLPI 0.04 cc and 0.06 cc was administered. In the next four days, the back skin was biopsied and stained by immunohistochemistry to analyze the CD163, FGF-2, IL-1 and IL-6 expression. Results The administration of rSLPI increased CD163 and FGF-2 expression dependent on dose (p<0.05). On the other hand, administration of rSLPI decreased IL-1 and IL-6 expression depending on dose (p <0.05). Conclusion The administration of rSLPI is able to accelerate the wound healing process by increasing the CD163 and FGF-2 expression. The cytokines such as IL-1 and IL-6 decreased depending on rSLPI doses.

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South Sulawesi Milkfish (Chanos Chanos) Scale Waste as a New Anti-inflammatory Material in Socket Preservation

Djais

Mappangara

Gani

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: One of South Sulawesi’s huge brackish water fishery product is milkfish (Chanos chanos). Scales are wasted in milkfish processing. However, they are a good source of chitosan, which has been found to promote anti-inflammation, wound healing, and bone regeneration. AIM: This study aims to determine the effect of milkfish scales waste on the inflammatory response of wound healing after tooth extraction by tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 analysis. METHODS: This is a post-test-only control group design study. Thirty-two Cavia cobaya were divided into four groups: (1) Socket preservation using milkfish scales chitosan, (2) milkfish scales chitosan + bovine xenograft, (3) bovine xenograft as a positive control, and (4) placebo as a negative control, then were sacrificed on 3rd, 7th, 14th, and 28th days. The mandible jaw specimen was taken for immunohistochemical analysis to determine the levels of TNF-α and IL-6. The data were analyzed using the Kolmogorov–Smirnov test, Levene’s test, and one-way analysis of variance. RESULTS: On days 3, 7, 14, and 28, groups with chitosan added showed lower levels of TNF-α and a faster decrease in IL-6 expressions compared to those without chitosan. CONCLUSION: Milkfish scale chitosan suppresses TNF-α and IL-6 production, thus reducing inflammation in socket preservation.

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Sponge amnion potential in post tooth extraction wound healing by interleukin-6 and bone morphogenetic protein-2 expression analysis: An animal study

Cited by 4 publications

References 19 publications

Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts

Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts

The Role of Recombinant Secretory Leukocyte Protease Inhibitor to CD163, FGF-2, IL-1 and IL-6 Expression in Skin Wound Healing

South Sulawesi Milkfish (Chanos Chanos) Scale Waste as a New Anti-inflammatory Material in Socket Preservation

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