Room temperature preparation of highly crosslinked microgels

Dvorakova, Gita; Biffis, Andrea

doi:10.1007/s00289-009-0134-z

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Polymers prepared using N80 formulation provided the biggest particles with the highest polydispersity in the series (Figure B). These findings were also observed by Dvorakova, where the degree of crosslinking has no significant effect on the sizes of highly cross‐linked microspheres prepared under photoinitiated polymerization using methyl methacrylate and EGDMA with DMF as solvent.…”

Section: Resultssupporting

confidence: 77%

“…Instead, the condition shifts to favor the formation of free template and monomers, thereby affecting the stability of the complex. Gratifyingly, this problem may be circumvented by using template‐monomer combination possessing excellent binding interactions or by shifting the equilibrium toward complex formation by running the polymerization reaction at lower temperature …”

Section: Introductionmentioning

confidence: 99%

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Room temperature synthesis and binding studies of solution‐processable histamine‐imprinted microspheres

Romano

Holdsworth

Quirino

et al. 2017

J of Molecular Recognition

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Accurate quantification of histamine levels in food and in biological samples is important for monitoring the quality of food products and for the detection of pathophysiological conditions. In this study, solution processable histamine-imprinted microspheres were synthesized at 30°C via dilute free radical phototochemical polymerization technique using ethylene glycol dimethacrylate (EGDMA) as the crosslinker and methacrylic acid (MAA) as the monomer. The processability of the resulting polymer is dictated by the monomer feed concentration (eg, 4 wt% 80:20 EGDMA:MAA formulation) and solvent (acetonitrile). Whereas, the particle size is influ- These results demonstrated that histamine-selective imprinted polymers can be obtained readily using room temperature photochemical polymerization where these materials can be subsequently used as recognition element for optical-based histamine sensing. KEYWORDSfrontal analysis capillary electrophoresis, histamine, microspheres, photochemical polymerization, processable, thermal polymerization 1 | INTRODUCTION Solution-processable imprinted polymers are highly crosslinked submicron-sized polymeric particles (ie, microgels, nano-gels, microspheres, or simple nanoparticles) that form stable dispersions in a given solvent without changing their overall structure including their binding pockets. 1 These polymers also possess more accessible sites providing better binding kinetics. [2][3][4] Due to these unique properties, these imprinted polymers are ideal for catalysis, 3-6 for drug delivery or controlled release, 7 and for sensing. [8][9][10][11][12] These polymers have been prepared via solution polymerization, 3,4,12,13 conventional thermal and controlled radical precipitation polymerization, 1 and mini-emulsion and micro-emulsion polymerization, 14 where the resulting processable polymers can be easily characterized as macromolecules both as a solid or in solution form using standard techniques.Even with the numerous advantages, 1 major drawback in using these polymers is the nature of preparation where high dilution polymerization is required. In a typical molecular imprinting process, a target molecule acts as a template where functional and cross-linking monomers (pre-polymer) are initially allowed to organize and preassemble, and then copolymerized to form binding sites complementary to the target template. The polymer framework is held together by the highly cross-linked structure. 15 In a highly dilute condition, the formation of a stable pre-polymer complex is not favored. Instead, the condition shifts to favor the formation of free template and monomers, thereby affecting the stability of the complex. Gratifyingly, this problem may be circumvented by using template-monomer combination possessing excellent binding interactions or by shifting the equilibrium toward complex formation by running the polymerization reaction at lower temperature. 16,17

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Section: Resultssupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Room temperature synthesis and binding studies of solution‐processable histamine‐imprinted microspheres

Romano

Holdsworth

Quirino

et al. 2017

J of Molecular Recognition

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“…Consequently, all microgels were initially characterized in solution using DLS and UV–vis spectroscopy. Attempts to analyze the microgels by gel permeation chromatography were futile due to their high crosslinking content (≥5%), as already noted by others. , …”

Section: Resultsmentioning

confidence: 95%

Crosslinked Microgels as Platform for Hydrolytic Catalysts

Sharma

Striegler

2018

Biomacromolecules

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In an effort to develop biomimetic glycosyl transfer catalysts, a polymerization protocol was developed that is applicable to the synthesis of crosslinked microgels via UV-initiated free radical polymerization of miniemulsions at ambient temperature and below. The catalytic activity of the microgels derived from butyl acrylate, EGDMA, and a catalyst-precursor ligand was established using the hydrolysis of 4-methylumbelliferyl β-d-galactopyranoside as a model reaction. The microgel-catalyzed hydrolysis was up to 3 × 10-fold accelerated over the background reaction and notably 38-fold faster than the hydrolysis catalyzed by its low molecular weight analog. Dynamic light scattering analysis demonstrated mean hydrodynamic diameters of the particles between 210 and 280 nm and chemical stability of the particles in aqueous solution between pH 1 and 13. A bell-shaped correlation between catalytic proficiency and material rigidity was observed that peaks at 40 mol % of crosslinking content of the microgel.

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Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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SummaryHerein we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004 to 2011. In total, 3779 references to the original papers, reviews, edited volumes and monographs from this period are included, along with recently identified uncited materials from prior to 2004 which were omitted in the first instalment of this series covering the years 1930 to 2003. 1 In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by sections describing fundamental aspects of molecular imprinting including the development of novel polymer formats. Thereafter, literature describing efforts to apply these polymeric materials to a range of application areas is presented. Current trends and areas of rapid development are discussed.2

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Room temperature preparation of highly crosslinked microgels

Cited by 5 publications

References 30 publications

Room temperature synthesis and binding studies of solution‐processable histamine‐imprinted microspheres

Room temperature synthesis and binding studies of solution‐processable histamine‐imprinted microspheres

Crosslinked Microgels as Platform for Hydrolytic Catalysts

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

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