ROS-degradable PEG-based wound dressing films with drug release and antibacterial properties

Paula, Carlos T. B.; Madeira, Ana B.; Pereira, Patrícia; Branco, Rita; Morais, Paula V.; Coelho, Jorge F. J.; Fonseca, Ana; Serra, Arménio C.

doi:10.1016/j.eurpolymj.2022.111447

Cited by 10 publications

(9 citation statements)

References 59 publications

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“…The methylene protons from HDI (PHP) and HMDI (PHMP) can be observed in the range of 1.50–1.18 ppm. The methyl protons from the IPDI (PIP) units are associated with the signals from 1.02 to 0.84 ppm 4 . The CH 2 protons between the 2 cycles of the HMDI (PHMP) lead to the signal at 0.94 ppm 47 …”

Section: Resultsmentioning

confidence: 99%

“…The methyl protons from the IPDI (PIP) units are associated with the signals from 1.02 to 0.84 ppm. 4 The CH 2 protons between the 2 cycles of the HMDI (PHMP) lead to the signal at 0.94 ppm. 47 When PPG is used, the region of 4.82 ppm together with the signal of the NH region shows urethane formation.…”

Section: H Nmr Spectroscopymentioning

confidence: 99%

“…Therefore, it is necessary to study the relationship between the chemical structures of the components to improve their properties and obtain new materials with specific applications. [1][2][3][4][5] The physical characteristics necessary in the specific application of the polymeric material must be provided by the components used for the synthesis of the polyurethanes. The structures of the soft segment and especially of the hard segment affect the properties because they act together on the degree of phase separation, crystallization, morphology and hydrogen bonds.…”

Section: Introductionmentioning

confidence: 99%

“…Polyurethane materials are widely used due to the diversity of their properties, which ensure the possibility of developing high‐quality products. Therefore, it is necessary to study the relationship between the chemical structures of the components to improve their properties and obtain new materials with specific applications 1–5 . The physical characteristics necessary in the specific application of the polymeric material must be provided by the components used for the synthesis of the polyurethanes.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and properties of water‐dispersible polyurethanes based on various diisocyanates and PEG as the hard segment

Oprea¹,

Potolinca²

2023

J of Applied Polymer Sci

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Water‐dispersible polyurethanes are a greener alternative to polyurethane solutions in organic solvents. Various polyurethane materials were prepared by a two‐step polymerization procedure of polypropylene glycol with Mn of 2000, polyethylene glycol with Mn of 1500, and diisocyanates with different chemical structures, aliphatic, cycloaliphatic and aromatic. It was investigated how the diisocyanate structure affected the molecular morphology, contact angle measurements, and physical characteristics of water‐dispersible polyurethanes. FTIR and NMR measurements showed a close relationship between the intermolecular connections and the hard segment structure, mainly of the diisocyanate used. Also, the polarized light method showed that the presence of the PEG in the hard domain improved aggregation through physical interactions due to its structural flexibility and mobility. These water‐dispersible polyurethanes can assure the use of these polyurethane materials in a broad range of applications with increased environmental protection.

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Section: Resultsmentioning

confidence: 99%

Section: H Nmr Spectroscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and properties of water‐dispersible polyurethanes based on various diisocyanates and PEG as the hard segment

Oprea¹,

Potolinca²

2023

J of Applied Polymer Sci

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“…Researchers have frequently investigated novel biomolecule-derived poly(lactic-co-glycolic acid)s (PLGAs) [1], polyurethanes (PUs) [2], and poly(ethylene glycol)s (PEGs) [3], biopolymers because of increasing attention to their biocompatibility, biodegradability superior mechanical properties, and chemical versatility. PLGA is biodegradable and biocompatible, displays different degradation times with chemical versatility has adjustable mechanical properties, and is an FDA and EMA-approved polymer [4,5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Poly(lactic-co-glycolic acid) Derived with LGlutamic Acid and L-Aspartic Acid

Önel

2023

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible, biodegradable polymer approved by the FDA and EMA, which is the most widely used in the field of health. In this study, PLGA was synthesized primarily from lactide and glycolide by polycondensation and ring-opening polymerization. Then, amino acid derivatives of PLGA were synthesized by the reaction of PLGA and amino acids in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The polymers synthesized were PLGA, PLGA-L-glutamic acid (PLGA-G), and PLGA-L-aspartic acid (PLGA-A). The chemical structure of these polymers was confirmed by 1H and 13C Nuclear Magnetic Resonance (1H NMR and 13C NMR), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Gel Permeation Chromatography (GPC). When the 13C NMR analyses of PLGA-amino acid derivatives were observed, an increase in the number of carbonyl carbons around 170 ppm was found and the structure accuracy was supported. In addition, when the FTIR analyses of PLGA-amino acid derivatives were examined, the structure was confirmed by observing the signal of the amide bond carbonyl vibration at 1700 cm-1. While the typical endothermic thermogram of the PLGA-amino acid derivative structures was observed by DSC analysis, it was shown that the structures were low molecular weight polymers [~5000-6000 Da] by GPC analysis.

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Responsive hydrogel dressings for intelligent wound management

Wang

Yeo

et al. 2023

BMEMat

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Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐heal acute wounds imposes a significant burden on healthcare systems. Wound healing is a complicated and dynamic physiological process with distinct molecular and cellular levels at each phase. Despite numerous strategies and advanced wound dressings being developed, successful wound management through smart dressing materials that can adapt to changing wound microenvironments and address the needs of wounds at different stages remains a big challenge. Over the last decade, hydrogel‐based dressings have emerged as one of the most potent biomaterials for wound treatment with favorable biological characteristics and a high potential for active intervention during the wound‐curing process. In the current contribution, we present the most recent progress in smart hydrogel dressings that can regulate the release of therapeutics in response to external stimuli (such as light) as well as endogenous changes in wound environments (e.g., temperature, pH, glucose, and reactive oxygen species) to facilitate wound healing. We also introduce the cutting‐edge technologies of intelligent “sense‐and‐treat” dressings through a combination of built‐in sensors or sensing molecules with responsive hydrogels, which enable real‐time monitoring of wound conditions and prompt on‐demand therapy.

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ROS-degradable PEG-based wound dressing films with drug release and antibacterial properties

Cited by 10 publications

References 59 publications

Synthesis and properties of water‐dispersible polyurethanes based on various diisocyanates and PEG as the hard segment

Synthesis and properties of water‐dispersible polyurethanes based on various diisocyanates and PEG as the hard segment

Synthesis and Characterization of Poly(lactic-co-glycolic acid) Derived with LGlutamic Acid and L-Aspartic Acid

Responsive hydrogel dressings for intelligent wound management

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