Rosacea and gastrointestinal disorders: a population‐based cohort study

Egeberg, Alexander; Weinstock, Leonard B.; Thyssen, Erik P.; Gislason, Gunnar; Thyssen, Jacob P.

doi:10.1111/bjd.14930

Cited by 128 publications

(109 citation statements)

References 35 publications

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“…Recent studies suggest that systemic comorbidities including coronary artery disease, hypertension, dyslipidaemia, gastrointestinal diseases, type 1 diabetes, multiple sclerosis and rheumatologic arthritis are significantly associated with rosacea . Regarding cancer risk in rosacea patients, little reliable data are available.…”

Section: Discussionmentioning

confidence: 99%

“…Lactobacillales can contribute to improved enteral conditions by regulating anti‐inflammatory responses, recovering gut integrity and decreasing gut permeability, and its abundance is increased in the faeces of patients with IBD compared to healthy individuals . Given that rosacea is associated with IBD, it is plausible that two diseases have an overlapping pathogenesis with regard to the aetiological implications of Lactobacillales. Previous studies have reported increased levels of Citrobacter in Crohn's disease (CD) and Desulfovibrio in ulcerative colitis (UC) .…”

Section: Discussionmentioning

confidence: 99%

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Rosacea and its association with enteral microbiota in Korean females

Nam

Yun

Kim

et al. 2017

Experimental Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rosacea and its association with enteral microbiota in Korean females

Nam

Yun

Kim

et al. 2017

Experimental Dermatology

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“…Egeberg et al . confirm common rosacea and gastrointestinal disorder coexistence, also regarding Helicobacter pylori infection and SIBO.…”

Section: Methodsmentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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“…However, given that Fusobacterium varium , which inhabits the enteral mucosa, was highly detected in colon tissue samples from patients with active ulcerative colitis (UC), along with increasing serum antibody levels of F. varium , a link between UC and Fusobacterium remains plausible [23]. The association between rosacea and UC has been well established by previous studies, based on the increased prevalence of UC in rosacea patients and the shared genetic background between rosacea and inflammatory bowel disease [10, 24]. In this regard, Fusobacterium may account for blood dysbiosis as well as enteral inflammation accompanied with rosacea, and thus may be a link between rosacea and UC.…”

mentioning

confidence: 99%