Rotavirus gastroenteritis.

Walker-Smith, J A

doi:10.1136/adc.53.5.355

Cited by 41 publications

(10 citation statements)

References 39 publications

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“…Thus, the adenoviruses and the parainfluenza viruses were particularly associated with tonsillitis and otitis media (Medical Research Council, 1965;Gardner, 1968;Clarke, 1973;Pereira, 1973). Diarrhoea was associated with rotavirus and with adenoviruses (Du Pont et at., 1977;Walker-Smith, 1978). Rashes were observed with measles virus and Coxsackie A viruses (Table 4).…”

Section: Discussionmentioning

confidence: 99%

Role of viruses in febrile convulsions.

Lewis¹,

Parry²,

Parry³

et al. 1979

Archives of Disease in Childhood

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SUMMARY A disseminated viral illness was demonstrated by isolating a virus from the CSF, blood, or urine in 27% of 73 children who were admitted to hospital after a first febrile convulsion However, a viral aetiology could be implicated for 86% of the children after combining results of tissue culture, electron microscopy, mouse inoculation, complement fixation tests, and interferon assay. Parallel bacterial cultures showed a possible pathogen in 29 % of children, but in only 4 % was the pathogen isolated from the CSF, blood, or urine. No correlation was found between the nature of the pathogen (or evidence of its dissemination) and the severity of the convulsion, degree of fever, CSF protein, CSF white cells, or the WBC. The results suggest that a febrile convulsion could be a response to invasion of the blood stream or central nervous system by a micro-organism which is usually a virus. Invasion may be of such brief duration that successful isolation of the virus from the blood, CSF, or urine is not more commonly achieved.

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Section: Discussionmentioning

confidence: 99%

Role of viruses in febrile convulsions.

Lewis¹,

Parry²,

Parry³

et al. 1979

Archives of Disease in Childhood

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“…Reports have universally shown that rotavirus particles can be seen in the stools of 15 to 90% of infants with diarrhoea but are absent from the stools of most healthy children. The highest isolation rates have been in temperate climates, particularly in the winter months (Bishop et al, 1974;Davidson et al, 1975;Kapikian et al, 1976;Dupont et al, 1977;Konno et al, 1977;Schoub et al, 1977;Walker-Smith, 1978).…”

mentioning

confidence: 99%

A year's experience of the rotavirus syndrome and its association with respiratory illness.

Lewis¹,

Parry²,

Davies³

et al. 1979

Archives of Disease in Childhood

101

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SUMMARY In a hospital study rotavirus was identified in 51 % of 152 children with diarrhoea. These patients showed a clinical pattern that was distinct from patients in whom the diarrhoea was associated with bacteria, other viruses, or no pathogens. A respiratory illness was described in 66 % of rotavirus patients and usually preceded the gastrointestinal symptoms. Vomiting lasted between one and 3 days and was curtailed by substituting the normal diet with clear fluids. Watery diarrhoea continued for 4 or 5 days, even when rehydration was by the intravenous rather than the oral route. Prolonged diarrhoea was rare. Most children infected with rotavirus were under 2 years of age, but dehydration was most severe in infants aged between 12 and 18 months. A clinician can thus recognise the rotavirus syndrome and expect spontaneous recovery if adequate rehydration is maintained for a critical few days.

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“…Because of the whell like apperance of virus under electron microscopy, the name 'rotavirus'was given in 1974 [3]. Not only humans, but almost all mammal and bird species can have rotavirus infections in newborns; although rotavirus was not reported in people until 1973, it has been reported earlier in animals [4].…”

Section: Introductionmentioning

confidence: 99%

Rotavirus genotypes in children with gastroenteritis in Erzurum: first detection of G12P[6] and G12P[8] genotypes in Turkey

Aydın

Aktaş

2017

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IntroductionRotavirus is one of the leading pathogens which cause acute gastroenteritis in children and is responsible for a substantial proportion of childhood deaths worldwide.AimTo determine the group A rotavirus (RVA) prevalence and genotypes of circulating RVA strains in 0–5-year-old children with complaints of vomiting and diarrhoea in Eastern Anatolia in Turkey.Material and methodsRNA extracted from stool specimens of 329 children aged 0–5 years with acute diarrhoea was subjected to reverse transcription polymerase reaction (RT-PCR) and multiplex-nested PCR. The genotypes were identified based on the expected size of the amplicon, which was amplified with a genotype-specific primer.ResultsOut of 329 stool samples analyzed, 109 (33.1%) were positive for RVA. G1P[8] was the dominant genotype combination (42.2%), followed by G9P[8] (21.1%) and G12P[6] (11.0%). Mixed infections were identified in 5 cases: G3,9 in 2 cases, G1,9 in 1 case, P[4,8] in 1 case, and P[6,8] in 1 case. The P genotype could not be typed in two patients.ConclusionsIn the study, we detected six different rotavirus G genotypes, 3 different P genotypes, 11 different G-P combinations and 5 different mixed genotypes combinations. G1, G9, G12 and P[8] were found to be the predominant genotypes. G12P[6] and G12P[8] genotypes, showing an increase as new rotavirus genotypes in the world, are reported for the first time for our regions. We determined the dominant genotypes, mixed genotypes and unconventional genotypes of rotavirus in our region.

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Rotavirus gastroenteritis.

Cited by 41 publications

References 39 publications

Role of viruses in febrile convulsions.

Role of viruses in febrile convulsions.

A year's experience of the rotavirus syndrome and its association with respiratory illness.

Rotavirus genotypes in children with gastroenteritis in Erzurum: first detection of G12P[6] and G12P[8] genotypes in Turkey

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