Rotavirus Gastroenteritis in a Neonatal Unit of a Greek Tertiary Hospital: Clinical Characteristics and Genotypes

Koukou, Dimitra; Chatzichristou, Panagiota; Trimis, Georgios; Siahanidou, Tania; Skiathitou, Anna-Venetia; Koutouzis, Emmanouil I.; Syrogiannopoulos, George A.; Lourida, Athanasia; Michos, Athanasios; Syriopoulou, Vassiliki

doi:10.1371/journal.pone.0133891

Cited by 23 publications

(27 citation statements)

References 54 publications

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“…The correlations between clinical signs and etiological factors in this study were consistent with other results (17,20,26,27). Fever, diarrhea and stools with blood, mucus and/or pus occurred more frequent in patients with bacterial AGE, while vomiting appeared more often in children with viral infections.…”

Section: Discussionsupporting

confidence: 91%

“…Występowanie objawów chorobowych w zależności od czynnika etiologicznego, pokazanych w prezentowanej pracy, pokrywa się z doniesieniami innych autorów (17,20,26,27). Gorączka, biegunka oraz patologiczne domieszki w kale częściej obserwowano w infekcjach bakteryjnych, natomiast w AGE o etiologii wirusowej znamiennie częściej występowały wymioty.…”

Section: Discussionunclassified

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Epidemiologic characteristics and clinical course of children with acute gastroenteritis hospitalized in the Department of Pediatric Infectious Diseases and Hepatology at John Paul II Hospital in Krakow

Rzucidło-Hymczak¹,

Hymczak²,

Plicner³

et al. 2018

Przegl Epidemiol

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INTRODUCTION. Acute gastroenteritis (AGE) is considered one of the most common reasons for hospitalization and the third leading cause of death related to infectious diseases in children. The incidence and prevalence of campylobacteriosis is lower in Poland than in other parts of the European Union. THE AIM OF THE STUDY. The aim of the study was to investigate the epidemiology and clinical features of AGE in hospitalized children. MATERIALS AND METHODS. The study population comprised 462 consecutive patients with AGE, hospitalized in the Department of Pediatric Infectious Diseases and Hepatology at John Paul II Hospital in Krakow during 2016. After admission in the hospital, the patients' stool samples were collected and tested for viral or bacterial pathogens. The specimens were analyzed using classical cultural methods and qualitative immunochromatographic assays for pathogens screening. The patients' age, sex, etiological factor, seasonal distribution, hospital length of stay and symptoms of disease were collected retrospectively. RESULTS. The median age of AGE patients was 3.0 years [1.5-5.5]. Eighty percent of all AGE cases occurred in patients under 5 years of age (p<0.001). Rotavirus was the leading cause of AGE and Campylobacter was the most common bacterial pathogen (p=0.001, p=0.05 respectively). The average length of hospital stay was 3.1 ± 1.6 days. The longest hospitalization stays were related to patients with enteropathogenic Escherichia coli and Salmonella (p<0.001 for all). A seasonal pattern was observed for etiological factors of AGE (p<0.001). Fever, diarrhea and pathological stool contaminations occurred more frequently in patients with bacterial AGE (p<0.001 for all). SUMMARY AND CONCLUSIONS. This study showed that routine diagnosis of Campylobacter in all children with AGE is associated with a higher than reported prevalence of campylobacteriosis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionunclassified

Epidemiologic characteristics and clinical course of children with acute gastroenteritis hospitalized in the Department of Pediatric Infectious Diseases and Hepatology at John Paul II Hospital in Krakow

Rzucidło-Hymczak¹,

Hymczak²,

Plicner³

et al. 2018

Przegl Epidemiol

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“…Rotavirus infection in children clinically manifests with several symptoms, such as fever, vomiting and watery, bloodless diarrhoea (25,26). These clinical manifestations are more severe than those of other causes of viral gastroenteritis (27).…”

Section: Discussionmentioning

confidence: 99%

“…Severe complications of rotavirus infection, such as bloody diarrhoea associated with necrotising enterocolitis (NEC) and bowel perforation, have been described (25,26,29). Even though they have not yet been fully elucidated, several factors were associated with the pathogenesis of the disease (30).…”

Section: Discussionmentioning

confidence: 99%

Identification of Rotavirus Strains Causing Diarrhoea in Children under Five Years of Age in Yogyakarta, Indonesian

Nirwati

Hakim

Aminah³

et al. 2017

MJMS

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Background: Rotavirus is an important cause of severe diarrhoea in children. The aims of this study were to identify the rotavirus strains that cause diarrhoea in children in Yogyakarta and to determine the association between rotavirus positivity and its clinical manifestations.Methods: Clinical data and stool samples were collected from children hospitalised at Kodya Yogyakarta Hospital, Indonesia. Rotavirus was detected in stool samples using an enzyme immunoassay (EIA), which was followed by genotyping using reverse transcriptase polymerase chain reaction (RT-PCR). Electropherotyping was performed for the rotavirus-positive samples.Results: In total, 104 cases were included in the study, 57 (54.8%) of which were rotavirus-positive. Based on a multiple logistic regression analysis, age group, vomiting and stool mucous were associated with rotavirus positivity. Most of the 56 samples subjected to genotyping were classified as G1 (80.36%) and P[8] (69.64%) genotypes. The genotype combination G1P[8] was identified as the most prevalent strain (66.07%). Of the 19 samples subjected to electropherotyping, 17 G1 isolates and 1 G3 isolate had long patterns, and 1 G1 isolate had a short pattern.Conclusion: G1P[8] was the most dominant strain of rotavirus causing diarrhoea in children in Yogyakarta. Age group, vomiting and stool mucous were associated with rotavirus positivity.

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“…Studying stool samples had revealed that Esch.coli were isolated from all 6 studied stool samples in infants with gastroenteritis. Esch.coli gastroenteritis in infants is rare where rotavirus (RV) is responsible for up to 87% of infantile diarrhea (34). Esch.coli is a normal inhabitants of the colon, and therefore, determination of the clinical significance of this isolation depends on the determination of whether the isolated strains were pathogenic or not.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Diagnosis of Bacterial Infections Among Children in the West Bank of Mosul City

AL-Hammadi¹

2020

J.Edu.Sci.

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Infections caused by bacteria are common in infants and neonates. Some of these infections are severe and usually carry high risk of fatal complications such as septicemia and / meningitis if left untreated. Very often, the diagnosis of these infections is clinical as well as laboratory diagnosis to determine the type of bacteria in body fluids such as urine, stool, blood and CSF. The present study aims to isolate and identify the bacteria responsible for some types of severe infections in neonates such as urinary tract infections (UTI), gastrointestinal tract (GIT) infections and bacteremia in West bank of Mosul city and test their susceptibility to different antibiotics. Twenty-seven (27) samples from blood, 28 from urine and 6 from stool were collected from neonates admitted to "Mosul General Hospital" in West Bank of Mosul city in the period between 1/7/2018 to 1/9/2018. Our results indicated that Staphylococcus aureus was the most common bacterial isolate in blood (81%), whereas both Staphylococcus aureus and Esch. coli were common in urine (48% and 43% respectively) followed by Proteus and Pseudomonas aeruginosa (4.5 % each). Both Staphylococcus aureus and Esch. coli were highly sensitive to amoxiclav (83% for and 100% respectively), levofloxacin (88% for Staphylococcus aureus and 100 % for Esch.coli) and meropenem (100% for both Staphylococcus aureus and Esch .coli). However, both of them were highly resistant to ampicillins (100%) and 3rd generation cephalosporins. Although meropenem is effective, it's use should be selected and restricted to highly resistant cases to avoid the emergence of early antibiotic resistance.

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Rotavirus Gastroenteritis in a Neonatal Unit of a Greek Tertiary Hospital: Clinical Characteristics and Genotypes

Cited by 23 publications

References 54 publications

Epidemiologic characteristics and clinical course of children with acute gastroenteritis hospitalized in the Department of Pediatric Infectious Diseases and Hepatology at John Paul II Hospital in Krakow

Epidemiologic characteristics and clinical course of children with acute gastroenteritis hospitalized in the Department of Pediatric Infectious Diseases and Hepatology at John Paul II Hospital in Krakow

Identification of Rotavirus Strains Causing Diarrhoea in Children under Five Years of Age in Yogyakarta, Indonesian

Isolation and Diagnosis of Bacterial Infections Among Children in the West Bank of Mosul City

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