Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver

Matović, Vesna; Buha, Aleksandra; Bulat, Zorica; Đukić-Ćosić, Danijela; Miljković, Milica; Ivanišević, Jasmina; Kotur‐Stevuljević, Jelena

doi:10.1016/j.fct.2011.12.035

Cited by 34 publications

(27 citation statements)

References 29 publications

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“…These observed changes are in accordance with our previous results and results of other authors who have suggested that Cd toxicity is mediated by decrease in antioxidant enzymes, production of reactive oxygen species and lipid peroxidation (13,14,22,23). However, more pronounced negative effects of Cd, except for SOD activity, were observed in rats that were treated intraperitoneally.…”

Section: Discussionsupporting

confidence: 83%

“…Similarly, no route-dependent changes in SOD activity were found in the liver of Cd-poisoned rats (13). The antagonism between Cd and Zn has been investigated for many decades, and it is known that Cd can replace Zn in many vital enzymatic reactions (24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

“…Oral and intraperitoneal doses of Cd producing toxic effects and Mg doses with possible protective effects were chosen on the basis of our previous experiments and literature data (10)(11)(12)(13)(14)(15) The animals were killed under ether anaesthesia twentyfour hours after Cd poisoning and blood samples taken from the heart and collected into heparin tubes. One portion of collected blood was used for cadmium, magnesium, and zinc determination, while the other portion was centrifuged at 837xg for 15 min and various parameters of oxidative stress were determined in the obtained plasma.…”

Section: Experimental Designmentioning

confidence: 99%

“…inhalation. Our previous study (13) has shown that oral pretreatment with Mg had benefi cial effects on all parameters of oxidative stress in the liver, suggesting gastrointestinal tract (GIT) as an important site of Cd and Mg interactions. However, the benefi cial effect of Mg ip treatment observed in that study showed that competition between Cd and Mg in GIT can not be the only explanation for the protective effects of Mg against Cd poisoning.…”

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confidence: 99%

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Effects of oral and intraperitoneal magnesium treatment against cadmium-induced oxidative stress in plasma of rats

Buha

Bulat

Đukić-Ćosić

et al. 2012

Archives of Industrial Hygiene and Toxicology

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Cadmium (Cd) has been recognised as one of the most important environmental and industrial pollutants, and up-to-date investigations have shown that one of the mechanisms of its toxicity is associated with the induction of oxidative stress. The aim of this study was to determine the connection between acute oral and intraperitoneal exposure to Cd and parameters indicative of oxidative stress in the plasma of rats, as well as to examine the potential protective effect of magnesium (Mg) in conditions of acute oral and intraperitoneal Cd poisoning. The experiment was performed on male albino Wistar rats (n=40) randomly divided into control group, Cdor group that received 30 mg kg-1 b.w. Cd by oral gavage, Cd+Mgor group that orally received 50 mg kg-1 b.w. Mg one hour before oral Cd, Cdip group that received 1.5 mg kg-1 b.w. Cd intraperitoneally, and Cd+Mgip group that intraperitoneally received 3 mg kg-1 b.w. Mg 10 min before intraperitoneal Cd. The animals were sacrifi ced 24 h after treatment and the following parameters were measured: superoxidedismutase activity, superoxide anion, total oxidative status, advanced oxidation protein products, and malondialdehyde. All parameters of oxidative stress in rat plasma were negatively affected by Cd treatment with more pronounced negative effects after intraperitoneal treatment, with the exception of superoxide dismutase (SOD) activity. Although both oral and intraperitoneal Mg pretreatment had protective effects, more pronounced benefi cial effects were observed after oral administration, since it managed to completely prevent Cd-induced changes in the investigated parameters. The observed results support the use of Mg as potential protective agent against toxic effects caused by Cd.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of oral and intraperitoneal magnesium treatment against cadmium-induced oxidative stress in plasma of rats

Buha

Bulat

Đukić-Ćosić

et al. 2012

Archives of Industrial Hygiene and Toxicology

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“…(9)(10)(11)(12)(13)(14). Furthermore, Cd toxic effects, especially as a result of chronic low-level exposure, can be connected with altered homeostasis of some bioelements (15,16).…”

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confidence: 99%

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat

Đukić-Ćosić²,

Antonijević³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg -1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg -1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO 3 ) and perchloric acid (HClO 4 ) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.

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Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

Mężyńska

Brzóska

2018

J of Applied Toxicology

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Recently, the growing attention of the scientific community has been focused on the threat to health created by environmental pollutants, including toxic metals such as cadmium (Cd), and on the need of finding effective ways to prevent and treat the unfavorable health effects of exposure to them. Particularly promising for Cd, and thus arousing the greatest interest, is the possibility of using various ingredients present in plants, including mainly polyphenolic compounds. As the liver is one of the target organs for this toxic metal and disturbances in the proper functioning of this organ have serious consequences for health, the aim of the present review was to discuss the possibility of using polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary and ginger) as the strategy in protection from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage. Owing to the ability of polyphenols to bind ions of Cd and the strong antioxidative potential of these compounds, as well as their abundance in dietary products, it seems to be of high importance to consider the possibility of using polyphenols as potential preventive and therapeutic agents against Cd hepatotoxicity, determined by its strong pro-oxidative properties. Although most of the data on the effectiveness of polyphenols comes from studies in animals, the fact that some of them are derived from experimental models that reflect human exposure to this metal allows us to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans.

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Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver

Cited by 34 publications

References 29 publications

Effects of oral and intraperitoneal magnesium treatment against cadmium-induced oxidative stress in plasma of rats

Effects of oral and intraperitoneal magnesium treatment against cadmium-induced oxidative stress in plasma of rats

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

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