Rowell's Syndrome

Fiallo, Paolo; Ag, Tagliapietra; Santoro, G; Venturino, Ezio

doi:10.1111/j.1365-4362.1995.tb01093.x

Cited by 23 publications

(29 citation statements)

References 2 publications

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“…Rhematoid factor positivity is the least preserved of all the features of RS, being previously described in only 41% of the patients, 1,6,10,12 and in both our cases. The presence of this immunologic parameter in DLE (17%), SLE (40%), scleroderma (40%), SCLE, and Sjogren's syndrome also disclaims its uniqueness to RS 16…”

Section: Discussionsupporting

confidence: 48%

“…The therapeutic response and prognosis in RS is similar to SLE or DLE occurring alone. A majority of the previously described cases followed an uneventful course and showed good response to steroids and antimalarials 6,10 . Dapsone has also been shown to be effective in a few cases 3 .…”

Section: Discussionmentioning

confidence: 96%

“…In both our patients, EM‐like lesions occurred against the background of SLE. Rowell described this finding in association with DLE, but 59% of the subsequent reports have demonstrated the acute EM‐like episodes in SLE patients 3,5–7,9–12,14 …”

Section: Discussionmentioning

confidence: 98%

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Rowell's syndrome revisited: report of two cases from India

2004

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 96%

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Rowell's syndrome revisited: report of two cases from India

2004

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“…Seventy per cent of Ro/SSA‐positive patients have RF 17 . Among cases showing association of lupus erythematosus and EM and reported under the name of Rowell’s syndrome, 22–27 most may represent a mere combination of lupus erythematosus and EM. Only a few patients had serological characteristics meeting Rowell’s original description, 22,23 the remaining patients being negative for ANA, RF or anti‐La/SSB 24–27 …”

Section: Discussionmentioning

confidence: 99%

Guillain–Barré syndrome in a child with systemic lupus erythematosus and anti‐Ro/SSA and anti‐La/SSB autoantibodies

Miyagawa¹,

Nakajima

Nishio³

et al. 2000

British Journal of Dermatology

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We report a 9‐year follow‐up of a girl with systemic lupus erythematosus (SLE) and probable Sjögren’s syndrome. At the age of 7 years, the patient developed a chilblain‐like eruption with features of SLE, including leucopenia, oral ulcers, positive rheumatoid and antinuclear antibodies and positive anti‐dsDNA, anti‐Ro/SSA and anti‐La/SSB antibodies. At the age of 13 years she developed Guillain–Barré syndrome, which completely resolved with aggressive treatment, including high‐dose corticosteroids and the use of plasma exchange followed by intravenous gammaglobulin.

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“…Whether EM-like annular skin lesions seen in SLE patients is an incidental association of a mere coexistence of LE and EM or a separate entity, it is difficult to determine [1]. It has been a matter of debate whether RS is pathogenically distinct from EM in the setting of SLE [1,5,10,11]. The majority of cases of RS reported in the literature do not fit the original description of RS, and it may be challenging to clinically differentiate between annular and polycyclic lesions of subacute cutaneous LE and EM [1].…”

Section: Clinicopathologic Discussionmentioning

confidence: 99%

Systemic Lupus Erythematosus Associated with Rowell's Syndrome

Kim

Magro

Granstein

et al. 2013

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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A 22-year-old man with systemic lupus erythematosus (SLE) presented with 2 weeks of a generalized rash and oral ulcers.The patient was diagnosed with SLE at the age of 3 based on malar rash, photosensitivity, oral ulcers, and arthritis, which were controlled with chronic low-dose corticosteroids and hydroxychloroquine. At the age of 18, the patient developed aseptic meningitis and acute left anterior uveitis; both were responsive to increased doses of corticosteroids. He did not follow up with a rheumatologist for approximately 4 years, during which time he took no medication until 4 months prior to admission when he experienced a lupus flare with malar rash, oral ulcers, fatigue, and neuropsychiatric symptoms including severe headache, distal paresthesias, slurred speech, and a subacute decline in mental status (difficulty concentrating, slowing thoughts, word finding difficulties, and memory loss). Laboratory testing at that time revealed a moderately high titer positive antinuclear antibody (ANA), in a coarse speckled pattern, and anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibody, normal levels of C3 and C4 and positive Ro (SS-A), Smith (Sm), U1-ribonucleoprotein, anticardiolipin immunoglobulin A (IgA) (42U), and Beta-2 glycoprotein-I IgA (57U) antibodies. The patient was treated with high-dose corticosteroids, started on hydroxychloroquine 200mg twice daily, aspirin 81mg, and esomeprazole 40mg once daily, with clinical improvement. Patient was subsequently tapered down on prednisone therapy accordingly from 60 to 40mg once daily regimen.Two weeks prior to admission at our institution, the patient developed new oral ulcers and generalized rash. The rash, which was minimally pruritic, initially appeared on his hands and arms, and then extended to his trunk and face, sparing his lower extremities and buttocks. Small painful vesicular lesions with serous discharge developed on his palms and fingers. His oral ulcers, initially discrete and small, became diffuse and painful and made it difficult for him to eat, as per patient's selfreport. He sought care at an emergency department at another institution where he was treated with intravenous valacycloir for possible disseminated herpes-simplex viral (HSV) infection and with vancomycin for a possible bacterial skin superinfection. Less than 24h there, the patient left against medical advice, and presented to our hospital the following day.The patient denied joint pain, neurological symptoms, fevers or chills, chest pain, shortness of breath, cough, diarrhea, constipation, dysuria, or hematuria. The patient had known allergies to penicillin and erythromycin, but no history of recent exposure to these drugs. His medications were prednisone 40mg alternating with 20mg daily, hydroxychloroquine 200mg twice daily, aspirin 81mg daily, and esomeprazole HSSJ

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Rowell's Syndrome

Cited by 23 publications

References 2 publications

Rowell's syndrome revisited: report of two cases from India

Rowell's syndrome revisited: report of two cases from India

Guillain–Barré syndrome in a child with systemic lupus erythematosus and anti‐Ro/SSA and anti‐La/SSB autoantibodies

Systemic Lupus Erythematosus Associated with Rowell's Syndrome

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