RP‐HPLC Method for the Estimation of Donepezil Hydrochloride Dosage Form

Abstract

A simple and accurate methods to determine donepezil, in tablet dosage form, were developed and validated using liquid chromatography (LC). The LC separation was achieved on a Inertsil C8-3, 25 cm x 4.6-mm, 5 µ in the isocratic mode using buffer : methanol : triethylamine (550:450:5)v/v, adjusted to pH 2.50±0.05 with orthophosphoric acid, as the mobile phase at a flow rate of 1.0 mL/min. The methods were performed at 271 nm. In LC method, quantification was achieved with PDA detection over the concentration range of 20-60 µg/mL with mean recovery of 100.18±0.75%. The method was validated by determining its sensitivity, accuracy and precision. The proposed method is simple, fast, accurate and precise and hence can be applied for routine quality control of donepezil HCl in bulk and tablet dosage form

Study on the preparation and drug release property of Modified PEG-DA based hydrogels

“…Donepezil has been investigated to be sufficient for enhancing of cognitive impairment and memory loss in patients with Alzheimer's disease. It is well efficient when 5 mg of the drug is used once daily (22)(23)(24)(25)(26)(27). 1.…”

Simultaneous Analysis of Indapamide and Related Impurities in Sustained-Release Tablets by a Single-Run HPLC-PDA Method

“…Referring to the quality standards of indapamide, indapamide tablets and indapamide sustained-release tablets in BP, USP, ChP and other literatures [15][16][17] , the contents of indapamide and the related impurities in generic indapamide sustained-release tablets, including 2methyl-1-nitroso-2,3-dihydro-1H-indole (Impurity A, denoted as ImA), ImB, Im1 and other unspecified impurities, were firstly detected simultaneously by a single-run high performance liquid chromatography equipped with photodiode array detector (HPLC-PDA) method in this paper. The results provided references for the quality control, consistency evaluation and quality standards study of generic indapamide sustained-release tablets.…”

Tip-loaded dissolving microneedles for transdermal delivery of donepezil hydrochloride for treatment of Alzheimer’s disease

“…However, the MW of DPH is close to the cutoff of MW (500), and the Log P of DPH is close to cutoff of Log P (5). In addition, because DPH is a hydrophilic molecule with a molecular weight of 415.96, its skin permeability is too low to achieve sufficient transdermal flux [13,14]. One study [15] sought to increase skin permeability by solubilizing DPH in propylene glycol containing fatty acid, but this method showed only a small increase in skin permeability.…”