Rs8193036 Polymorphism of Il-17a Gene in a Kazakh Population and Its Association With Plasma Il-17a Among Erysipelas Patients

Abstract

We studied associations between rs8193036 polymorphism of IL-17A gene (C737T) and plasma levels of IL-17A in patients with erysipelas and healthy subjects in a Kazakh population. The rs8193036 polymorphism was assessed in 95 patients with erysipelas and 383 control subjects. The IL-17A (rs8193036) polymorphism was studied by a real time polymerase chain reaction. Plasma levels of IL-17A were assessed in 90 patients with erysipelas and 90 healthy subjects by enzyme immunoassay. Categorical data were analyzed using Pearson's Chi tests and odds ratios (OR) with 95 % confidence intervals (CI). Continuous data were studied using Kruskal -Wallis and Mann-Whitney tests with Bonferroni correction. We found that T allele occurred more frequently (OR = 1.41; 95 % CI: 0.21-0.92) while allele C (OR = 0.71; 95 % CI: 0.51-0.99) and genotype CC (OR = 0.44; 95% CI: 0.21-0.92) occurred less frequently in cases than in controls. In erysipelas patients with CC genotype the level of IL-17A was significantly higher (p = 0.010) compared to the carriers of CT genotype. Also, the levels of IL-17A in patients with erysipelas was higher than among controls in groups with both CC and CT genotypes (p = 0.023 and p = 0.020, respectively). These data suggest that the rs8193036 polymorphism of IL-17A gene may play a role in the etiology of erysipelas, but other factors are also involved.

Correlations of IL-17 and NF-κB gene polymorphisms with susceptibility and prognosis in acute respiratory distress syndrome in a chinese population

“…Located in the regulatory domain of IL-17, SNP of rs2275913 can reduce IL-17 expression, relieve severe inflammatory reaction and intervene ARDS development [23]. Nevertheless, C>T at rs8193036 can increase IL-17 expression, activate and boost the inflammatory reaction, which finally contribute to higher risk of ARDS [24]. The distribution profiles of the two SNPs were consistent with that on ARDS risk and prognosis, indicating that rs2275913 and rs8193036 should affect ARDS initiation and progression via regulating the expression of IL-17.…”