RuCl3 catalyses aldol condensations of aldehydes and ketones

Synthesis and Biological Activity of Novel 2,5-Dichloro-3-Acetylthiophene Chalcone Derivatives

“…All compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) were synthesized by a mixture of 2,5-dichloro-3-acetylthiophene (0.001 mol) and the appropriate aryl or heteroaryl aldehyde (0.001 mol) were stirred in methanol (10 mL). To this mixture an aqueous solution of KOH (40%, 5 mL) was added with continuous stirring.…”

“…6,7,8,9,10,11 The use of several Lewis acids (p-toluene sulfonic acid, B 2 O 3 , RuCl 3 , AlCl 3 , BF 3 and dry HCl) has also been demonstrated. 12,13,14,15,16,17 The most important catalysts were used and listed as solid sodium hydroxide (NaOH) and aqueous NaOH. Andreson et al, in 2001, introduced first time a solid sodium hydroxide method in a hydroxy chalcone derived from cinnamon.…”

“…Then, it was purified by column chromatography and crystallized from a mixture of ethyl acetate and hexane (1:1) (Scheme-I). Reagents and conditions: (i) potassium hydroxide (KOH), (ii) Room temperature condition; (iii) Methanol; The structural group of R in scheme-1 is specified below (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and the synthesis was carried out with individual type of aromatic or heteroaromatic aldehydes to synthesize various chalcone derivatives with 2,5-dichloro-3-acetylthiopene ring (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) as in the Table 1. The mechanism of formation of novel synthetic chalcone was shown below in Figure 1.…”

“…The MIC was taken as that concentration used in the test tube number just prior to the test tube number labelled where the first sign of growth was observed. This procedure was followed to determine the MIC values for all the compounds of series of new chalcone derivatives with 2,5-dichloro-3-acetylthiopene ring (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). It is shown in the Table 2.…”

Synthesis of Biologically Active Chalcon Analogues via Claisen-Schmidt Condensation in Solvent-Free Conditions: Supported Mixed Addenda Heteropoly Acid as a Heterogeneous Catalyst

“…H 5 PMo 10 V 2 O 40 (Mo 10 V 2 ) showed excellent reactivity among different kinds of the catalysts (Table 1). HPAs with Keggin structures are flexible in their acid strength and have low toxicity and fairly high thermal stability, so they are excellent and versatile catalysts for a wide variety of organic reactions in both homogeneous and heterogeneous media 24,25 . By immobilization of HPAs into convenient carriers, the reaction easily carry out in a heterogeneous which has some advantages like increase the accessibility to the acid sites and control solid acid strength.…”