Micro, small and medium enterprises are the backbone of the economy in all countries, including Indonesia. Various disturbances that occur, especially in the era of uncertainty, have selected MSMEs. MSMEs that continue to exist show that these MSMEs have high resilience. This study aims to explore the disturbances faced and the survival strategy of MSMEs in the fisheries sector of Takalar Regency in an era of uncertainty. The research was conducted from August to October 2021. MSMEs in the fisheries sector in Takalar Regency are the object of research because this sector has experienced many disturbances but still exists and is one of the main contributors to the GRDP of Takalar Regency. The research method uses descriptive analysis and focuses on group discussion. Descriptive analysis data were obtained from in-depth surveys and interviews of 100 MSME entrepreneurs in the fisheries sector of Takalar Regency, and data for focus group discussion analysis were obtained from 10 msME experts in the fisheries sector. The results showed that internal factors of MSMEs and external factors caused supply disruptions and price stability in MSMEs in the fisheries sector of Takalar Regency. Internal factors of MSMEs are the quality and quantity of human resources, lack of technology, limited MSME finances, and low quality of the products produced. External factors are environmental damage, the phenomenon of climate change, water pollution, overfishing, high input prices, and fuel scarcity. MSMEs have tried to solve the causes of disruption in new ways and methods. The conclusion of this study is the disruption that occurs in MSMEs in the fisheries sector, namely, supply disruptions and price stability faced by MSMEs with innovative strategies.