Ruthenium(II) arene complexes of curcuminoids: Synthesis, X-ray diffraction structure and cytotoxicity

Lei, Xiaolin; Su, Wei; Li, Peiyuan; Xiao, Qi; Huang, Shan; Qian, Quanquan; Huang, Chusheng; Qin, Danni; Lan, Hongxian

doi:10.1016/j.poly.2014.07.019

Cited by 23 publications

(24 citation statements)

References 25 publications

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“…These complexes can be very important to develop the medicinal chemistry of bioorganometallic complexes as metal based photocytotoxic agents 90 . Two ruthenium-arene complexes containing curcuminoid ligands (η6-p-cymene) Ru(CUR)Cl-CUR -thiophene aromatic curcuminoids have been synthesized by Lei et al 91 . The complexes were evaluated for their in vitro antiproliferative activities against Hela human cervical epithelioid cancer, as well as BEL-7404 and SMMC-7721 human liver cancer cell lines.…”

Section: Metal Complexes Of Curcuminoids and Their Biological Activitiesmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

730

413

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In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

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Section: Metal Complexes Of Curcuminoids and Their Biological Activitiesmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

730

413

View full text Add to dashboard Cite

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“…We report the chemical characterization and in vitro antitumor activity on 5 tumor cell lines of related complexes where the curcumin-like ligands are less polar than the parent compound. Other investigators have studied Ru complexes of curcumin modified at its aromatic rings by thiophene moieties [38], in contrast with our ligands that conserve the entire curcumin structural skeleton. Curcumin, HCurcI and HCurcII ligands also are studied in the same cell lines for comparison.…”

Section: Introductionmentioning

confidence: 99%

The in vitro antitumor activity of arene-ruthenium(II) curcuminoid complexes improves when decreasing curcumin polarity

Caruso

Pettinari

Rossi

et al. 2016

Journal of Inorganic Biochemistry

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“…Inspired by these facts, we investigated the interaction between a novel Ru(II) arene complex with curcumin analogs and ctDNA using viscosity measurement, the DNA melting technique, multispectroscopic techniques and electrochemical methods. Herein, a novel Ru(II) arene complex with curcumin analogs [( η 6 ‐ p ‐cymene)Ru(thiophene aromatic curcuminoids)Cl]Cl, which shows lower IC 50 values than other Ru(II) arene complex with curcumin analogs , was chosen. This study will help us to better understand the interaction mechanism between Ru(II) arene complex with curcumin analogs and ctDNA and will provide valuable information on the biological influences of these Ru(II) anticancer drugs in organisms.…”

Section: Introductionmentioning

confidence: 99%

Systematical investigation of binding interaction between novel ruthenium(II) arene complex with curcumin analogs and ctDNA

Huang

Yu²,

Huang

et al. 2016

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In this study, the interaction between a novel ruthenium(II) arene complex with curcumin analogs and calf thymus DNA (ctDNA) was investigated systematically by viscosity measurement, the DNA melting approach, multispectroscopic techniques and electrochemical methods. The absorption spectra of the ctDNA-drug complex showed a slight red shift and a weak hypochromic effect. The relative viscosity and melting temperature of ctDNA increased on addition of the drug. The evidence obtained from fluorescence competitive experiments indicated that the binding mode of the drug with ctDNA was intercalative. Using acridine orange (AO) as a fluorescence probe, the drug statically quenched the fluorescence of the ctDNA-AO complex, and hydrogen bonding and van der Waals interactions played vital roles in the binding interaction between the drug and ctDNA. The influences of ionic strength, chemical denaturants and pH on the binding interaction were also investigated. Circular dichroism and Fourier transform infrared spectra suggested that this drug might bond with the G-C base pairs of ctDNA and the right-handed B-form helicity of ctDNA remained after drug binding. The intercalative binding between the drug and ctDNA was further investigated using electrochemical techniques. All these results suggested that the biological activity of ctDNA was affected by ruthenium(II) arene complex with curcumin analogs. Copyright © 2016 John Wiley & Sons, Ltd.

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Ruthenium(II) arene complexes of curcuminoids: Synthesis, X-ray diffraction structure and cytotoxicity

Cited by 23 publications

References 25 publications

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

The in vitro antitumor activity of arene-ruthenium(II) curcuminoid complexes improves when decreasing curcumin polarity

Systematical investigation of binding interaction between novel ruthenium(II) arene complex with curcumin analogs and ctDNA

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