S136 The association between cough reflex sensitivity and serum ACE level in patients with sarcoidosis

Abstract

key determinants of smoking, gender, DM, HTN, hypercholesterolaemia and BMI. On univariate analysis, BMI was significantly higher in the NSIP subgroup (p¼0.025 vs UIP or INDET). Rates of STEMI and strokes were highest in UIP cases (n/s) whereas that of CABG was highest in the INDET subgroup. These observations were corrected for IPF severity in so far as FVC and DL CO were decreased comparably across all three radiological subgroups. Evaluation of co-existing COPD was not undertaken; however, mean FEV 1 did not differ between groups. Conclusions Amongst patients with clinical IPF, UIP morphology correlates with the highest risk of cardiovascular morbidity compared to NSIP. A tendency for ischaemic heart disease to precede IPF in the majority of cases suggests the possibility that broader systemic or cardiac-specific factors may influence the pathogenesis of these pulmonary disorders. Conclusion Although these data represent only a proportion of patients undergoing allogeneic HSCT, we found 10% of patients developed impaired PFT at 12 months with large falls in FEV 1 and FVC. These data suggest there may be as many as 60 to 120 HSCT recipients each year developing major impairment of lung function. Multi-centre prospective studies are required to fully characterise the frequency and risk factors for impaired PFT post-HSCT.

Cough in Sarcoidosis

“…In the study by Sinha et al, patients with sarcoidosis and cough reported triggers of cough and laryngeal sensations commonly reported by patients with CHS [22]. Triggers such as odours, changes in air temperature, smoke, speech and symptoms of [13]. There was a strong association between self-reported triggers and cough frequency assessed objectively.…”

“…In an unselected group of patients with pulmonary sarcoidosis, 50 % had an abnormal raised cough frequency assessed objectively with a validated 24-h cough monitor, the Leicester Cough Monitor (LCM) [14]. The average cough frequency was within the range reported for patients with idiopathic chronic cough [13,15]. Sinha et al also investigated the impact of cough on health-related quality of life (HRQOL) with a validated questionnaire: the Leicester Cough Questionnaire (LCQ) [16].…”

“…Dagnell et al reported increased nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and their receptors TrKA and TrKB [23]. Sinha et al investigated for the first time cough reflex sensitivity in patients with sarcoidosis [13]. Cough reflex sensitivity was assessed with a capsaicin challenge test and was significantly heightened compared to a healthy control group.…”

“…Sinha et al evaluated cough in sarcoidosis in a recent study [13]. In an unselected group of patients with pulmonary sarcoidosis, 50 % had an abnormal raised cough frequency assessed objectively with a validated 24-h cough monitor, the Leicester Cough Monitor (LCM) [14].…”

Cough in chronic lung disease: a state of the art review

“…Sinha et al . reported heightened CRS was associated with lower serum ACE level (r=0.72) though there was no association between serum ACE and objective CFreq ( 4 , 62 ). Meanwhile, Gvozdenovic et al .…”