Sa2063 Mirnas Contribute to the Probiotic Effect of E.coli Nissle 1917 on Host Cells Offering New Perspectives for Inflammatory Bowel Disease Treatment

Cichon, Christoph; Veltman, Katharina; Hummel, Stephanie; Sonnenborn, U.; Schmidt, M. Alexander

doi:10.1016/s0016-5085(12)61489-9

Cited by 1 publication

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“…In the more UC like dextran sulfate sodium (DSS) colitis model (miR-155) or in the more CD like T cell transfer model (mir-10a) different miRNAs, indicating the different origin of the disease, are upregulated during the course of the inflammation. 85-88 Wu et al. were able to show that different sets of miRNAs also represent the degree of inflammation in ulcerative colitis (UC) and Crohn´s disease (CD).…”

Section: Mirna and Barrier Functionmentioning

confidence: 99%

MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions

et al. 2014

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Tightly controlled epithelial and endothelial barriers are a prerequisite for life as these barriers separate multicellular organisms from their environment and serve as first lines of defense. Barriers between neighboring epithelial cells are formed by multiple intercellular junctions including the ‘apical junctional complex—AJC’ with tight junctions (TJ), adherens junctions (AJ), and desmosomes. TJ consist of tetraspan transmembrane proteins like occludin, various claudins that directly control paracellular permeability, and the ‘Junctional Adhesion Molecules’ (JAMs). For establishing tight barriers TJ are essential but at the same time have to allow also selective permeability. For this, TJ need to be tightly regulated and controlled. This is organized by a variety of adaptor molecules, i.e., protein kinases, phosphatases and GTPases, which in turn are regulated and fine-tuned involving microRNAs (miRNAs). In this review we summarize available data on the role and targeting of miRNAs in the maintenance of epithelial and/or endothelial barriers.

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Section: Mirna and Barrier Functionmentioning

confidence: 99%