Saccharomyces cerevisiae: A novel and efficient biological control agent for Colletotrichum acutatum during pre-harvest

Lopes, Marcos Roberto; Klein, Mariana Nadjara; Ferraz, Luriany Pornpeo; Silva, Aline Caroline da; Kupper, Kátia Cristina

doi:10.1016/j.micres.2015.04.003

Cited by 67 publications

(41 citation statements)

References 27 publications

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“…In addition to the development of novel biocontrol agents to prevent latent infections, a biocontrol agent (as well as a chemical compound) may be applied early in the season or even during the flowering stage. Therefore, application of biocontrol agents in the field during the growing season has been suggested (Ippolito and Nigro 2000;Lima et al 1997;Lopes et al 2015). However, knowledge on epidemiology of the causal agents of latent postharvest diseases is limited.…”

Section: Biological Control Agentsmentioning

confidence: 99%

Latent postharvest pathogens of pome fruit and their management: from single measures to a systems intervention approach

Wenneker

Thomma

2020

Eur J Plant Pathol

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Postharvest diseases of pome fruit are typically caused by a wide diversity of fungal pathogens, and the list of confirmed causal agents is still growing. There is considerable knowledge on the epidemiology of wound pathogens, such as Botrytis cinerea and Penicillium expansum. In contrast, knowledge on the occurrence of the different postharvest diseases caused after latent (quiescent) infections during long-term storage and their epidemiology is limited. Well-known pathogens causing postharvest losses after latent infections are Neofabraea spp. and Colletotrichum spp., but in many cases the causal agents that occur in a specific region remain unknown and their control relies on the routine use of fungicide applications. However, due to the growing concern over the use of synthetic fungicides, alternative control measures are highly desired. Over the past years the use of physical treatments, natural compounds, and biocontrol agents have been investigated as alternatives. However, no single method has emerged that can robustly and reliably control postharvest diseases of pome fruit in practice. In this review it is argued to approach latent postharvest diseases as complex problems that require multiple interventions at different stages of the disease process in a systems intervention approach for their control. Such approach requires a deep understanding of the epidemiology of the causal agents in the orchard, fruit defence mechanisms against pathogens, and the molecular biology of host-pathogen interactions in order to develop novel disease control methods in which the deployment of resistant cultivars can be a cornerstone.

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Section: Biological Control Agentsmentioning

confidence: 99%

Latent postharvest pathogens of pome fruit and their management: from single measures to a systems intervention approach

Wenneker

Thomma

2020

Eur J Plant Pathol

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“…Fungal co-culturing techniques have been used previously to mimic in vitro microbial interactions occurring in their natural environment and to identify new antifungal compounds (Liu et al, 2001; Kim et al, 2015; Lopes et al, 2015; Ting and Jioe, 2016). We selected B. cinerea as a model to be used in fungal co-cultures and to induce the production of new SMs derived from fungal interactions.…”

Section: Resultsmentioning

confidence: 99%

Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents

et al. 2017

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New fungal SMs (SMs) have been successfully described to be produced by means of in vitro-simulated microbial community interactions. Co-culturing of fungi has proved to be an efficient way to induce cell–cell interactions that can promote the activation of cryptic pathways, frequently silent when the strains are grown in laboratory conditions. Filamentous fungi represent one of the most diverse microbial groups known to produce bioactive natural products. Triggering the production of novel antifungal compounds in fungi could respond to the current needs to fight health compromising pathogens and provide new therapeutic solutions. In this study, we have selected the fungus Botrytis cinerea as a model to establish microbial interactions with a large set of fungal strains related to ecosystems where they can coexist with this phytopathogen, and to generate a collection of extracts, obtained from their antagonic microbial interactions and potentially containing new bioactive compounds. The antifungal specificity of the extracts containing compounds induced after B. cinerea interaction was determined against two human fungal pathogens (Candida albicans and Aspergillus fumigatus) and three phytopathogens (Colletotrichum acutatum, Fusarium proliferatum, and Magnaporthe grisea). In addition, their cytotoxicity was also evaluated against the human hepatocellular carcinoma cell line (HepG2). We have identified by LC-MS the production of a wide variety of known compounds induced from these fungal interactions, as well as novel molecules that support the potential of this approach to generate new chemical diversity and possible new therapeutic agents.

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“…Several antagonistic microorganisms have been recommended to be used in fields before harvest with the purpose of protecting postharvest cultivation [7,29]. Lopes et al [110] assessed the efficacy of different antagonistic microorganisms in controlling Colletotrichum acutatum with applications on preharvest citrus fruit and found promising results. Silva and De Costa [111] assessed the potential of Burkholderia spinosa with preharvest applications for the BC of phytopathogens in banana (Musa spp.).…”

Section: Application Of Biocontrol Agents In Preharvest Stagesmentioning

confidence: 99%

Biocontrol of Postharvest Fruit Fungal Diseases by Bacterial Antagonists: A Review

et al. 2019

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This review deals with the main mechanisms of action exerted by antagonistic bacteria, such as competition for space and nutrients, suppression via siderophores, hydrolytic enzymes, antibiosis, biofilm formation, and induction of plant resistance. These mechanisms inhibit phytopathogen growth that affects postharvest fruit since quality and safety parameters are influenced by the action of these microorganisms, which cause production losses in more than 50% of fruit tree species. The use of synthetic fungicide products has been the dominant control strategy for diseases caused by fungi. However, their excessive and inappropriate use in intensive agriculture has brought about problems that have led to environmental contamination, considerable residues in agricultural products, and phytopathogen resistance. Thus, there is a need to generate alternatives that are safe, ecological, and economically viable to face this problem. Phytopathogen inhibition in fruit utilizing antagonist microorganisms has been recognized as a type of biological control (BC), which could represent a viable and environmentally safe alternative to synthetic fungicides. Despite the ecological benefit that derives from the use of controllers and biological control agents (BCA) at a commercial level, their application and efficient use has been minimal at a global level.

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Saccharomyces cerevisiae: A novel and efficient biological control agent for Colletotrichum acutatum during pre-harvest

Cited by 67 publications

References 27 publications

Latent postharvest pathogens of pome fruit and their management: from single measures to a systems intervention approach

Latent postharvest pathogens of pome fruit and their management: from single measures to a systems intervention approach

Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents

Biocontrol of Postharvest Fruit Fungal Diseases by Bacterial Antagonists: A Review

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