Safe core-satellite magneto-plasmonic nanostructures for efficient targeting and photothermal treatment of tumor cells

Bertorelle, Fabrizio; Pinto, Marcella; Zappon, Roberta; Pilot, Roberto; Litti, Lucio; Fiameni, S.; Conti, Giamaica; Gobbo, Marina; Toffoli, Giuseppe; Colombatti, Marco; Fracasso, Giulio; Meneghetti, Moreno

doi:10.1039/c7nr07844g

Cited by 31 publications

(37 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The core should be engineered in order to optimize the enhancement in the spectral region of interest; this aim can be pursued, for example, by using nanoparticles with different shapes (i.e., nanospheres [416], nanostars [317], etc. ), by aggregating nanoparticles to form dimers or trimers [417,418], or by fabricating more complex structures that possess a high density of hot spots (i.e., core-satellite systems [419]). The introduction in the core of a magnetic functionality allows one to separate the analyte from the (possibly) complex matrix in which it is immersed and to concentrate it [419,420].…”

Section: Fabrication Of Sers Substratesmentioning

confidence: 99%

A Review on Surface-Enhanced Raman Scattering

et al. 2019

Self Cite

View full text Add to dashboard Cite

Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.

show abstract

Section: Fabrication Of Sers Substratesmentioning

confidence: 99%

A Review on Surface-Enhanced Raman Scattering

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…With regard to the nanosystem layout, different hybrid magneto‐plasmonic configurations based on gold and iron oxide including core/shell, [ 13i,19 ] heterodimer and dumbbell structures, [ 20 ] core–satellite, [ 21 ] and nanoclusters [ 12a,22 ] have been designed for biomedical purposes. Among the broad range of possible architectures, Janus nanoparticles have attracted increased scientific interest in the technological and biomedical fields.…”

Section: Introductionmentioning

confidence: 99%

Janus Magnetic‐Plasmonic Nanoparticles for Magnetically Guided and Thermally Activated Cancer Therapy

Espinosa

Reguera

Curcio

et al. 2020

Small

108

View full text Add to dashboard Cite

Progress of thermal tumor therapies and their translation into clinical practice are limited by insufficient nanoparticle concentration to release therapeutic heating at the tumor site after systemic administration. Herein, the use of Janus magneto‐plasmonic nanoparticles, made of gold nanostars and iron oxide nanospheres, as efficient therapeutic nanoheaters whose on‐site delivery can be improved by magnetic targeting, is proposed. Single and combined magneto‐ and photo‐thermal heating properties of Janus nanoparticles render them as compelling heating elements, depending on the nanoparticle dose, magnetic lobe size, and milieu conditions. In cancer cells, a much more effective effect is observed for photothermia compared to magnetic hyperthermia, while combination of the two modalities into a magneto‐photothermal treatment results in a synergistic cytotoxic effect in vitro. The high potential of the Janus nanoparticles for magnetic guiding confirms them to be excellent nanostructures for in vivo magnetically enhanced photothermal therapy, leading to efficient tumor growth inhibition.

show abstract

“…At first, gold nanoparticles (AuNP) were produced by laser ablation synthesis in solution (LASiS), as previously reported for a wide range of materials [44][45][46]. Briefly, Nd:YAG nanosecond laser pulses were focused on a pure gold plate in a micromolar NaCl solution.…”

Section: Sers Nanostructures and Model For Sers Labeled Cellsmentioning

confidence: 99%

Single File Flow of Biomimetic Beads for Continuous SERS Recording in a Microfluidic Device

Calzavara

Ferraro

Litti

et al. 2018

Advances in Condensed Matter Physics

Self Cite

View full text Add to dashboard Cite

A major challenge in cancer treatment is the quantification of biomarkers associated with a specific cancer type. Important biomarkers are the circulating tumor cells (CTCs) detached from the main cancer and circulating in the blood. CTCs are very rare and their identification is still an issue. Although CTCs quantification can be estimated by using fluorescent markers, all the fluorescence techniques are strongly limited by the number of emissions (therefore markers) that can be discriminated with one exciting line, by their bleaching characteristics, and by the intrinsic autofluorescence of biological samples. An emerging technique that can overcome these limitations is Surface Enhanced Raman Scattering (SERS). Signals of vibrational origin with intensity similar to those of fluorescence, but narrower bandwidths, can be easily discriminated even by exciting with a single laser line. We recently showed the benefit of this method with cells fixed on a surface. However, this approach is too demanding to be applied in clinical routine. To effectively increase the throughput of the SERS analysis, microfluidics represents a promising tool. We report two different hydrodynamic strategies, based on device geometry and liquids viscosity, to successfully combine a microfluidic design with SERS.

show abstract

Safe core-satellite magneto-plasmonic nanostructures for efficient targeting and photothermal treatment of tumor cells

Cited by 31 publications

References 67 publications

A Review on Surface-Enhanced Raman Scattering

A Review on Surface-Enhanced Raman Scattering

Janus Magnetic‐Plasmonic Nanoparticles for Magnetically Guided and Thermally Activated Cancer Therapy

Single File Flow of Biomimetic Beads for Continuous SERS Recording in a Microfluidic Device

Contact Info

Product

Resources

About