Safety and Efficacy of Preoperative Tattooing with Charcoal Nanoparticles for Laparoscopic Resection of Gastric Tumors

Wang, Yu; Ma, Jun; Huang, Sheng; Wang, Rong; Jiang, Chuanshen; Yu, Li; Lin, Nan; Yang, Weixiao; Wang, Wen

doi:10.1166/jnn.2016.11328

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Wang et al evaluated the imaging efficacy of charcoal nanoparticles during laparoscopic surgery for gastrointestinal cancer. 51 The nanoparticles served as a tattoo agent and located tumors within a short time. Subsequent pathologic examination revealed that tumors in all removed tissues, which indicated nanotechnology contributed to a precise removal of gastric cancer.…”

Section: Nanotechnology Approaching Gastric Cancermentioning

confidence: 99%

Nanotechnology-based strategies for gastric cancer imaging and treatment

et al. 2021

RSC Adv.

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Section: Nanotechnology Approaching Gastric Cancermentioning

confidence: 99%

Nanotechnology-based strategies for gastric cancer imaging and treatment

et al. 2021

RSC Adv.

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“…Since 2013, based on the advantages and effectiveness of carbon nanoparticles (7), we carried out a new exploration of nanocarbon dyes in precision surgery for gastrointestinal (8,9), thyroid (10), and breast (11) tumors, providing a basis for finding a new and effective staining method. Furthermore, we previously conducted a retrospective analysis of the short-term follow-up of preoperative carbon nanoparticle staining in 16 breast cancer patients and also performed a preliminary study of carbon nanoparticle staining before neoadjuvant chemotherapy in 3 patients.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-assisted carbon nanoparticle labeling of neoadjuvant chemotherapy for breast-conserving surgery in breast cancer

Lin¹,

Liu²,

Wang³

et al. 2023

Quant Imaging Med Surg

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Background: Neoadjuvant chemotherapy has gradually become an important means of breast cancer treatment; however, tumor regression following chemotherapy remains a concern. This study was conducted to investigate the effect of ultrasound-assisted carbon nanoparticle labeling in neoadjuvant chemotherapy for breast-conserving surgery in breast cancer.Methods: This was a prospective clinical trial study (clinical registration number: ChiCTR-OOC-15006844). Sixty-eight breast cancer patients confirmed by biopsy between July 2015 and January 2017 were randomly selected from the clinical data. Of these, 32 patients were screened for neoadjuvant chemotherapy, forming a consecutive, random series. An ultrasound-guided carbon nanotube was used to mark the original tumor, and sentinel lymph node biopsies were performed. After 4-6 cycles of standard neoadjuvant chemotherapy, 26 patients were selected for breast-conserving surgery. The feasibility and validity of carbon nanoparticle labeling were analyzed through the negative rate of incision margin, the volume of resected tumors, the detection rate of black-stained sentinel lymph nodes, the recurrence rate of ipsilateral breast, and postoperative survival.Results: In all, 32 patients underwent sentinel lymph node biopsy, 29 cases were detected (90.6%), the false-negative rate was 3.8% (1/26), and 0-4 sentinel lymph nodes (mean 1.8±1.1) were detected. A total of 26 patients underwent breast-conserving surgery, 5 underwent secondary excision, and 1 underwent subcutaneous adenectomy due to a positive margin. The minimum margin between the resected site and the infiltrated part was 1.0-2.1 cm (1.3±0.3 cm). The diameter of resected tumors ranged from 2.2 to 4.5 cm (3.1±0.6 cm). No recurrence or distant metastasis of ipsilateral breast tumors was observed during follow-up (the median follow-up time was 9 months).Conclusions: Ultrasound-assisted carbon nanoparticle labeling is effective for sentinel lymph node tracing before neoadjuvant chemotherapy and has a high detection rate for metastatic lymph nodes. During breastconserving surgery, it can determine the extent of tumor resection to achieve precision surgical treatment.

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“…However, it is difficult to identify small lesions in EGC during laparoscopic surgery even for a skilled surgeon. [ 8 ] Because EGCs do not involve the serosal layer, the location of a tumor cannot be determined by the laparoscopic view alone. [ 2 ] Without precise preoperative localization, a large portion of the stomach has to be dissected to ensure complete eradication of the cancer tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, some patients still need subsequent surgical resections owing to positive resection margins. [ 8 ] Thus, correct identification of the tumor location is very important, especially for gastric cancer in the middle third of the stomach. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

Role of preoperative endoscopic clipping in laparoscopic distal gastrectomy for early gastric cancer

Park

Moon²,

Sul³

et al. 2018

Medicine

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In this study, we evaluate the usefulness of preoperative endoscopic clipping for early gastric cancer (EGC) localization in laparoscopic distal gastrectomy.We retrospectively screened all consecutive patients who underwent laparoscopic distal gastrectomy for EGC by 1 surgeon at Chungnam National University Hospital between January 2014 and December 2016. Patients who underwent combined surgery and patients who had tumors at the lower third of the stomach were excluded. Endoscopic clipping was performed prior to surgery by specialized endoscopists. During the operation, endoscopic metal clips were found using surgical devices, and laparoscopic vessel clips were attached on the presumed site; thereafter, intraoperative radiographs were obtained for confirmation.We analyzed a total of 196 patients; of them, 101 were classified into the clipping group (CG) and 95 into the non clipping group (NCG). The 2 groups were comparable regarding their demographic characteristics. The CG showed less additional resection (2 of 101 patients [2.0%] vs 9 of 95 patients [9.4%], P = .021) and better outcomes in terms of the operation time (P = .000), duration of hospital stay (P = .036), and postoperative atelectasis (P = .001) than the NCG.Preoperative endoscopic clipping was helpful in determining the exact resection margin in laparoscopic distal gastrectomy for EGC.

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Safety and Efficacy of Preoperative Tattooing with Charcoal Nanoparticles for Laparoscopic Resection of Gastric Tumors

Cited by 3 publications

References 10 publications

Nanotechnology-based strategies for gastric cancer imaging and treatment

Nanotechnology-based strategies for gastric cancer imaging and treatment

Ultrasound-assisted carbon nanoparticle labeling of neoadjuvant chemotherapy for breast-conserving surgery in breast cancer

Role of preoperative endoscopic clipping in laparoscopic distal gastrectomy for early gastric cancer

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