Safety and immunogenicity of a soluble native Neospora caninum tachyzoite-extract vaccine formulated with a soy lecithin/β-glucan adjuvant in pregnant cattle

Mansilla, Florencia Celeste; Moore, D.P.; Quintana, María Eugenia; Cardoso, Nancy Patricia; Hecker, Yanina P.; Gual, Ignacio; Czepluch, Wenzel; Odeón, Anselmo Carlos; Capozzo, Alejandra Victoria

doi:10.1016/j.vetimm.2015.03.007

Cited by 15 publications

(6 citation statements)

References 23 publications

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“…This is the first report describing the effect of N. caninum profilin on dendritic cells and the assessment of its immunogenicity. The vaccine containing a recombinant profilin (rNcPRO) was formulated with an adjuvant containing TLR-2 agonists, which has already been used in mice and cattle (Mansilla et al, 2013, Mansilla et al, 2012, Mansilla et al, 2015; vaccines prepared with this particular adjuvant and low doses of sNcAg induced protection in BALB/c mice (Mansilla et al, 2012). The rationale was to favor the activation of MyD88 pathway in antigen presenting cells by tacking different TLRs, as MyD88 is required for resistance against N. caninum in mice (Mineo et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice

Mansilla

Quintana

Langellotti

et al. 2016

Experimental Parasitology

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Section: Discussionmentioning

confidence: 99%

Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice

Mansilla

Quintana

Langellotti

et al. 2016

Experimental Parasitology

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“…More recently, Mansilla et al . reported on the safety and immunogenicity of a soluble native N. caninum tachyzoite‐extract vaccine formulated with a soya lecithin/β‐glucan adjuvant in pregnant cattle. This formulation had previously been shown to be protective in the mouse model and induced strong IFN‐γ responses and high‐avidity antibodies in nonpregnant cattle .…”

Section: Vaccine Development: Present Statusmentioning

confidence: 99%

Vaccines for bovine neosporosis: current status and key aspects for development

Horcajo

Regidor‐Cerrillo

Aguado‐Martínez

et al. 2016

Parasite Immunology

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SUMMARYBovine neosporosis is a worldwide concern due to its global distribution and great economic impact. Reproductive failure in cattle due to abortion leads to major economic losses associated with the disease. Currently, there is no treatment or vaccine available against abortion or transmission caused by Neospora caninum infection in cattle. However, vaccination is considered the best measure of control against bovine neosporosis. Several host and parasite factors can influence the dynamics of the infection in bovines. Moreover, the availability of well-defined infection models is a key factor for the evaluation of vaccine candidates. However, working with cattle is not easy due to difficult handling, facilities and costs, and therefore, 'more affordable' models could be used for screening of promising vaccines to establish proof of concept. So far, live-attenuated vaccines have shown good efficacy against exogenous transplacental transmission; however, they have relevant disadvantages and associated risks, which render inactivated or subunit vaccines the best way forward. The identification of novel potential targets and vaccines, and the application of innovative vaccine technologies in harmonized experimental animal models, will accelerate the development of an effective vaccine against bovine neosporosis.

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“…Vaccine research has been under way for a long time, and most approaches have focused on inactivated whole vaccines (killed tachyzoites), 109 – 111 the use of subunit native (tachyzoite-extract vaccine formulated with a soy lecithin/β-glucan adjuvant) 112 , 113 and recombinant N. caninum antigens, 114 – 117 and live naturally attenuated parasites. 118 – 120 …”

Section: Treatment Prevention and Controlmentioning

confidence: 99%

Canine neosporosis: perspectives on pathogenesis and management

Silva¹,

Machado²

2016

VMRR

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Canine neosporosis is a worldwide disease caused by the obligate intracellular parasite protozoan Neospora caninum, manifesting mainly neurological symptoms. N. caninum has a heteroxenous life cycle and affects a wide range of warm-blooded animals. The domestic and wild canids are the definitive host of the parasite. They shed oocysts after ingestion of tissue cysts from infected intermediate hosts (ovine, equine, bovine, canine, and many other species), containing bradyzoites, or oocyst-contaminated water and food. The presence of dogs in farms is considered a risk factor for production animals. A wide range of diagnostic methods are currently available, but the most used is serology, ie, indirect fluorescent antibody test specific to the antibody detection in blood serum samples. No vaccine is available, but control strategies should be focused on the vertical and horizontal transmission of the parasite, ie, avoid feeding dogs with raw or undercooked meat, and taking care with water for human and animal consumption. No medicines to control the transplacental transmission are available yet.

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Safety and immunogenicity of a soluble native Neospora caninum tachyzoite-extract vaccine formulated with a soy lecithin/β-glucan adjuvant in pregnant cattle

Cited by 15 publications

References 23 publications

Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice

Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice

Vaccines for bovine neosporosis: current status and key aspects for development

Canine neosporosis: perspectives on pathogenesis and management

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