Safety considerations for working with animal models involving human health hazards

Carpenter, Calvin B.

doi:10.1002/ame2.12019

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…We created a questionnaire, which has a total of 29 questions and is divided into 5 sections, 2 of which contain Likert-style questions (see Section 3 in the SI for details), by reviewing and analyzing literature studies. ,− This questionnaire was created because there is not a readily available questionnaire on laboratory safety awareness that can be used to thoroughly assess laboratory safety awareness among university students at our university. Then, using the questionnaire, a cross-sectional study of the students was carried out.…”

Section: Methodsmentioning

confidence: 99%

Determination of University Students’ Laboratory Safety Awareness: A Cross-Sectional Study

Wu,

Yang,

2023

J. Chem. Educ.

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Based on four types of laboratory safety questions (chemical, biological, physical, and medical), a cross-sectional survey of students at Kunming University of Science and Technology (China) was carried out to determine the awareness of laboratory safety among university students. The survey was completed by 335 students in total, with a response rate of 95.71%. GHS pictograms, attitudes toward lab safety, practices for lab safety, and emergency equipment and procedures were all covered in the survey. The survey's findings showed that 63.58% of students did not have an excellent awareness of laboratory safety. With mean scores of 2.56 and 2.20, respectively, the student's ability to identify GHS pictograms and laboratory emergencies was poor. In addition, close to 5% of students maintained a negative attitude toward laboratory safety, and a small number of students (1.79−6.27%) reported never having complied with any of the measures in the questionnaire regarding laboratory safety practices. Comparative analysis revealed statistically significant relationships between different majors, whether they had experienced laboratory safety training and some survey questions (p < 0.05), and further identified factors and odds ratio values (5.382−8.037) that influence students' awareness of laboratory safety. Based on the results of the research, specific recommendations for instructors, university administrators, and the government are also given to improve university students' awareness of laboratory safety.

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Section: Methodsmentioning

confidence: 99%

Determination of University Students’ Laboratory Safety Awareness: A Cross-Sectional Study

Wu,

Yang,

2023

J. Chem. Educ.

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“…Laboratory personnel require personal protective equipment, which varies depending on the pathogen and the specific nature of the laboratory work. The staff should undergo training and lab skills testing on a regular basis [10]. BSL3 laboratories investigate a range of EIDs, with the exception of the especially virulent viral infections as Ebola, Marburg, Congo-Crimean hemorrhagic fever, Junin, Lassa, and Hendra viruses, which are usually handled in the highly containment BSL-4 facilities [11].…”

Section: Introductionmentioning

confidence: 99%

Some Specific Biological Risks of SARS-CoV-2 Infected Syrian Hamsters at Animal Biosafety Level - Lab 3

Vilkova,

Rinat,

Turebekov

et al. 2024

Global Biosecurity

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The emergence of novel severe acute respiratory syndrome 2 (SARS-CoV-2) has prompted extensive research to identify its pathogenesis, transmission, and reservoir entry in animals. Syrian hamsters (Mesocricetus auratus) are being identified as an ideal animal model for the study of SARS-CoV-2 infection due to their susceptibility and respiratory symptoms similar to that observed in humans. This study focused on the specific biological risks associated with the use of infected Syrian hamsters in animal biosafety level 3 (ABSL-3) laboratories. The professional and psychological training of professionals working with laboratory animals should be a priority. Biological safety requires the involvement of all parties from technical staff to top management. The COVID-19 pandemic has shown a limitation in experimental studies when obtaining the right strain of mice proved difficult. A rare experimental model of Syrian hamsters started to be used in the work, which Syrian hamsters have several distinctive characteristics associated with increased aggressiveness of females, leading to a requirement to keep them isolated and some technical difficulties during manipulations in the biological safety cabinet. Therefore, a risk-based approach must be introduced to reduce the additional risks to workers to an acceptable level. This includes enhanced accuracy in the use of personal protective equipment (PPE), rigorously following biosecurity protocols, and monitoring staff health to detect potential risk of zoonotic transmission. The implementation of international standards and regulations on biological safety and biosecurity is of paramount importance.

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“…We are surrounded by modern chemical and biological hazards and diseases that in everyday life we recognize as lumpy skin disease, avian influenza, swine flu, and bluetongue disease, various types of salmonellae, trichinella, tapeworms, and anthrax. If we add also radioactive substances, plant and animal toxins and inorganic toxins (arsenic-rat poison, potassium cyanide) and physical hazards in food (glass, metal particles) then legal, institutional, organizational, scientific-educational, pedagogical, human resources, operationaltactical and other measures need to be undertaken in order to protect people, facilities and objects (Ntemiri et al, 2019, Carpenter, 2018Corradini et al, 2018;Froude et al, 2011). All the measures stated above are implemented through cooperation and exchange of information among police, laboratories, inspectorates and other authorities.…”

Section: Introductionmentioning

confidence: 99%

Sensory-Biological-Chemical Protection of States Persons in Montenegro

Spalević¹,

Spalević²,

Spalević³

et al. 2021

AgricultForest

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In this paper we presented the results of a study on sensory-bio-chemical checks in facilities on the territory of Montenegro visited, regardless of the reason, by national states persons and foreign states persons during their visits to Montenegro. The checks concern the total number of checks, results of compliance, structure of the premises and relations within the checks. The checks were carried out by specialized police officers, officers of inspectorates and national laboratories. We analysed 965 checks over 11 years, with 551 checks showing compliance with the requirements or 57.1% and 414 checks showing non-compliance with the requirements or 42.9%. Detection of non-compliant swabs and samples using scientific and technological analyses prevented poisoning of states persons. Most of the checks were carried out in hotel-tourism facilities, then in residential-type facilities and the lowest number of checks was carried out in other facilities. The total number of checks rose by 6.11% on average per annum, on the basis of which a forecast of checks by 2022 was given.Based on results of the study, proposals are given in the conclusion, aimed at further improvement of work of the police and other authorities. There is also a need for modernization of capacities in terms of human resources and technical equipment and for continuous monitoring of hazards in the field of sensorybiological-chemical protection with a view to preventing possible threats for state persons.

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Safety considerations for working with animal models involving human health hazards

Cited by 5 publications

References 6 publications

Determination of University Students’ Laboratory Safety Awareness: A Cross-Sectional Study

Determination of University Students’ Laboratory Safety Awareness: A Cross-Sectional Study

Some Specific Biological Risks of SARS-CoV-2 Infected Syrian Hamsters at Animal Biosafety Level - Lab 3

Sensory-Biological-Chemical Protection of States Persons in Montenegro

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