Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells

Hu, Xiaolan; Zhang, Xianqi; Qiu, Shuifeng; Yu, De‐Quan; Lin, Sabrina

doi:10.1016/j.bbrc.2010.06.033

Cited by 83 publications

(66 citation statements)

References 24 publications

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“…Recently, research in apoptosis induction therapy has been performed with medicinal plants that were known to be chemopreventive candidates with few side effects. [22][23][24] Caspases, cysteine-containing aspartate-specific proteases, play an important role in apoptosis. 25 Activation of caspases is central to the execution of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Ginkgo May Sensitize Ovarian Cancer Cells to Cisplatin

et al. 2012

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Ginkgolide B (GB), the primary active component of Ginkgo biloba extracts, may have antitumor properties. The objective of this study was to determine the effects and possible mechanisms of GB in ovarian cancer cells. In this study, human ovarian cancer cell lines (SKOV3 and CAOV3) were treated with different concentrations of GB alone or in combination with Cis-diaminodichloroplatinum (CDDP). An MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was performed to determine cell viability. The apoptosis rates of cells were measured by flow cytometric analysis. The expression of apoptosis-associated and proliferation-associated proteins was detected by Western blot. The cytotoxicity of GB was analyzed using a lactate dehydrogenase assay. Treatment with 100 µM GB for 3 days significantly inhibited SKOV3 and CAOV3 cell proliferation by 57.3% and 63.1% compared with control cells, respectively, as determined by MTT assay. Similarly, the apoptotic cell population was increased when treated with GB in a dose-dependent manner both in SKOV3 and CAOV3 cells. These effects were characterized by the upregulation of p21, p27, cleaved capase-3, and cleaved caspase-8 and downregulation of cyclin D1. In addition, a combined treatment of low concentrations of GB and CDDP showed an additive effect on the inhibition of SKOV3 cell proliferation. Furthermore, GB had significantly less cytotoxicity than CDDP in normal human ovarian surface epithelial cells. This study suggests that GB can be proposed as an effective antiproliferative and apoptosis-inducing agent with interesting translational application in ovarian cancers, used in addition to conventional chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Ginkgo May Sensitize Ovarian Cancer Cells to Cisplatin

et al. 2012

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“…[19] In a further study, we will focus on investigating (i) the uncertain effect of the salidroside-epirubicin compound; and (ii) the dose-related pharmacologic and probable toxicologic effects of salidroside.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer

et al. 2012

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Background: Salidroside [2-(4-hydroxyphenyl)ethyl-b-D-glucopyranoside], one of the most potent ingredients extracted from the plant Rhodiola rosea L., has been shown to have a cardiovascular protective effect as an antioxidant, and early treatment of epirubicin-induced cardiotoxicity has been the focus of clinical chemotherapy in patients with breast cancer. However, the cardioprotective effects of salidroside on epirubicin-induced cardiotoxicity, especially early left ventricular regional systolic dysfunction, have to date been sparsely investigated. Objective: The aim of this study was to investigate the protective effects of salidroside in preventing early left ventricular regional systolic dysfunction induced by epirubicin. Methods: Sixty patients with histologically confirmed breast cancer were enrolled. Eligible patients were randomized to receive salidroside (600 mg/day; n = 30) or placebo (n = 30) starting 1 week before chemotherapy. Patients were investigated by means of echocardiography and strain rate (SR) imaging. We also measured plasma concentrations of reactive oxygen species (ROS). All parameters were assessed at baseline and 7 days after each new epirubicin dose of 100 mg/m 2 . Results: A decline of the SR peak was observed at an epirubicin dose of 200 mg/m 2 , with no significant differences between salidroside and placebo (1.35 -0.36 vs 1.42 -0.49/second). At growing cumulative doses of epirubicin, the SR normalized only with salidroside, showing a significant difference in comparison with placebo at epirubicin doses of 300 mg/m 2 (1.67 -0.43 vs 1.32 -0.53/second, p < 0.05) and 400 mg/m 2 (1.68 -0.29 vs 1.40 -0.23/second, p < 0.05). Moreover, a significant increase in plasma concentrations of ROS was found with placebo, but they remained unchanged with salidroside.

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“…The effects are potentially mediated by changes in serotonin and dopamine levels due to monoamine oxidase inhibition and its influence on opioid peptides such as β-endorphins. Additionally, Rhodiola rosea and/or its major active ingredients have been reported to induce cell-cycle arrest and apoptosis in human breast cancer cells (Hu et al, 2010), reduce high-altitude sickness and mental problems (Gupta et al, 2010). It protects neuronal cells from oxidative stress (Qu et al, 2009;Yu et al, 2010;Zhang et al, 2010), reduces or abolishes bingeing-related eating disorders (Cifani et al, 2010) and suppresses adipogenesis and lipid accumulation (Lee et al, 2011).…”

Section: Rhodiola Rosea (Hong Jing Tian)mentioning

confidence: 99%

Panax ginsengRhodiola roseaandSchisandra chinensis

Chan

2011

International Journal of Food Sciences and Nutrition

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Panax ginseng (Ginseng), Rhodiola rosea (Hong Jing Tian) and Schisandra chinensis (Wu Wei Zi) are well-known herbs in traditional Chinese medicine (TCM). Recently, there have been a number of studies on these 3 herbs. This review discusses their active components and major pharmacological effects. For Panax ginseng, it has been shown to have an anti-inflammatory activity, affects pulmonary function and erectile dysfunction, improves cognition in patients with Alzheimer's disease and promotes sexual arousal in menopausal women as well as prevent cancer. For Rhodiola rosea, its effectiveness on alleviating depression and reducing fatigue are summarized in this review.Additionally, anti-cancer and other clinical effects of Schisandra chinensis are also discussed. These 3 herbs are considered as adaptogens as they bear multiple functions and their effects were found to be very different in subjects depending on the circumstances (age, gender, environment, diet, season, etc.). Thus, in most cases, the art of the TCM practitioner is to prescribe these herbs after a complete evaluation of patients' overall heath status.

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Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells

Cited by 83 publications

References 24 publications

Ginkgo May Sensitize Ovarian Cancer Cells to Cisplatin

Ginkgo May Sensitize Ovarian Cancer Cells to Cisplatin

Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer

Panax ginsengRhodiola roseaandSchisandra chinensis

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