Salinomycin residues and their ionophoricity in pig tissues

Dimenna, Gary P.; Lyon, F.S.; Creegan, James A.; Wright, George J.; Wilkes, Laurie C.; Johnson, Dallas E.; Szymanski, T. A.

doi:10.1021/jf00094a024

Cited by 12 publications

(10 citation statements)

References 2 publications

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“…Using a microbiological assay, they were able to detect salinomycin, only occasionally, at concentrations of less than 10 ng/g in muscle and kidney; and to detect it at concentrations of around 10 ng/g in liver of chickens following in-feed administration of 60mg/kg salinomycin, without withdrawal. One other study, by Dimenna et al (1990), reported undetectable levels of [ 14 C]salinomycin in the kidney fat and muscle of pigs treated with 41 mg/kg [ l4 C]salinomycin, without withdrawal. They did, however, detect salinomycin in liver, at a concentration of about l-8ng/g.…”

Section: Discussionmentioning

confidence: 99%

Development of an ELISA for salinomycin and depletion kinetics of salinomycin residues in poultry

Kennedy¹,

Blanchflower²,

O'Dornan³

1995

Food Additives and Contaminants

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Salinomycin is widely used as a feed additive to control coccidiosis in the broiler industry world-wide. EC legislation on veterinary drug residues will soon be extended to cover poultry. This will require the development of rapid assays to screen for the presence of residual concentrations of this and other drugs in poultry meat. This study describes the development of an enzyme-linked immunosorbent assay for salinomycin that has a limit of detection of approximately 0.2 ng/g. The antibody cross-reacts with narasin, but is not subject to interference from lasalocid, maduramicin or monensin. Residual concentrations of salinomycin were measured in the tissues of broilers following feeding of medicated feed containing 60 mg/kg salinomycin. Salinomycin residues were present only at very low concentrations in liver and muscle, and fell below the limit of decision of the assay within 2 days of withdrawal of the medicated feed.

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Section: Discussionmentioning

confidence: 99%

Development of an ELISA for salinomycin and depletion kinetics of salinomycin residues in poultry

Kennedy¹,

Blanchflower²,

O'Dornan³

1995

Food Additives and Contaminants

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“…Salinomycin is able to penetrate blood brain barrier, though the existence of P-glycoprotein could limit its oral availability and brain penetration [54]. Liver is the primary site for metabolizing salinomycin; rapid hepatic biotransformation of salinomycin yields numerous metabolites [55]. The elimination of salinomycin is moderately fast; 24 hours has been suggested as an adequate withdrawal period for salinomycin in chickens [53].…”

Section: Pharmacokinetic Parameters Of Salinomycin As An Anti-coccidimentioning

confidence: 99%

Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

Zhou¹,

Wang²,

Wong³

et al. 2013

CMC

123

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Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent despite its largely unknown mechanism of action. This review summarizes the pharmacologic effects of salinomycin and presents possible mechanisms by which salinomycin exerts its anti-tumorigenic activities. Recent advances and potential complications that might limit the utilization of salinomycin as an anti-cancer and anti-CSC agent are also presented and discussed.

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“…Moreover, Atef et al (1993) concluded that the highest concentration of Salinomycin was in liver, kidneys, muscles, fat and heart. They also mentioned that the toxic effect induced by Salinomycin may be due to its action on cellular cations homeostasis (Westley, 1983) or residual effects on tissue cells (Dimenna et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on The Effects of Enzymes Feed Additive“Kemzyme” and Antibiotic Growth Promoter "Salinomycin" on Haemostatic Mechanism of Rabbit Bucks

Bughdadi¹,

Attia²,

Saleh³

2013

JAS

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The present study was designed to investigate the effects of enzymes (Kemzyme) or antibiotic (Salinomycin) feed additives on haemostatic mechanism and some haemostatic parameters in rabbit bucks.Twenty four rabbit bucks of average age 4 months were used and allocated into 3 equal groups (8/ each); control un-supplemented, Kemzyme and Salinomycin supplemented groups. The supplements were mixed with the ration for 8 successive weeks. Blood samples were collected at the end of the 4 th and the 8 th weeks of the experiment. Results obtained revealed that: 1) Kemzyme supplementation was not associated with any significant alterations in the measured parameters and 2) at the end of the 8 th . week , salinomycin adversely affected the haemostatic mechanism in the form of hypocoagulabe state manifested by a significant increase in PT and APTT with a significant decrease in coagulation factors VII, IX and X activities. It could be concluded that kemzyme is a more safer feed additive .While, salinomycin should not be used for more than 4 weeks to avoid its adverse effect on haemostasis that could be a cause of sudden death resulting in economic losses or rendering the rabbit meat unmarketable due to inter and intramuscular patches of bleeding.

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Salinomycin residues and their ionophoricity in pig tissues

Cited by 12 publications

References 2 publications

Development of an ELISA for salinomycin and depletion kinetics of salinomycin residues in poultry

Development of an ELISA for salinomycin and depletion kinetics of salinomycin residues in poultry

Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

A Comparative Study on The Effects of Enzymes Feed Additive“Kemzyme” and Antibiotic Growth Promoter "Salinomycin" on Haemostatic Mechanism of Rabbit Bucks

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