Salivary analysis in oral cancer patients

“…Disruption of the equilibrium between the generation and removal of free radicals leads to oxidative stress and changes in the macromolecules, such as nucleic acid, lipids, and proteins (12). Currently, mounting evidence suggests that free radicals play a pivotal role in tissue transformation into malignancy (13,14).…”

Section: Discussionmentioning

confidence: 99%

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

et al. 2018

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Background: Oxidative stress has been shown to be the most significant influential factor in cancer pathogenesis. Follicular cells are affected in papillary thyroid carcinoma (PTC), which is the most prevalent thyroid cancer associated with oxidative stress. As a noninvasive source of body metabolism, saliva has recently attracted the attention of researchers as an investigative specimen. The present study aimed to evaluate and compare the levels of total antioxidant capacity (TAC) and malondialdehyde (MDA) in the blood and saliva samples of PTC patients and healthy control subjects. Methods: This case-control study was conducted on the patients with PTC referring to Taleghani Hospital in Tehran, Iran. Age-and gender-matched healthy volunteers were selected as the control group. Blood and saliva samples were obtained from all the subjects. Measurement of the MDA and TAC levels was performed using a commercial kit (ZellBio GmbH, Germany) based on colorimetric methods. Data analysis was performed in MedCalc software version 14.8.1.

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“…On the other hand, 8-OHdG level has been studies in oral pathologies, including periodontal disease [25,[32][33][34][35] and oral cancer [36]. As described above, in periodontitis OxS because of the formation of ROS, which is stimulated by neutrophils, produce damage of the bonesupporting tissues.…”

Section: Periodontitis and Oxs: Nuclear And Oxidative Dna Damagementioning

confidence: 99%

Periodontal Disease and Nuclear and Oxidative DNA Damage

Zamora‐Pérez¹,

Zúñiga‐González²,

Gómez‐Meda³

et al. 2017

Insights Into Various Aspects of Oral Health

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Oral health is an important aspect of the overall health status of an individual. DNA damage has been associated with oral health and dental factors due to the increased of oxidative stress (OxS). DNA damage can produce a wide range of effects on human health. These effects could appear immediately, but others do not become evident much later. Chronic diseases have been study to understand their mechanisms, clinical implications, and the development of secondary disease such as cancer. Periodontitis is one of the most common oral diseases. It is an inflammatory chronic infectious disease, which is characterized by the loss of supporting tissues and tooth loss caused by periodontopathogens and long-term release of reactive oxygen species (ROS); thus, oxidative stress is increased during periodontitis. Oxidative stress can produce DNA damage, including the oxidation of nucleosides, which could cause DNA strand break. This oxidative damage leads the formation of micronuclei (MN) a marker of nuclear damage. Also, oxidative stress increased 8-hydroxy-2′-deoxyguanosine levels which are the most common stable product of oxidative DNA damage.

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Salivary analysis in oral cancer patients

Cited by 156 publications

References 78 publications

Analysis of Salivary Antioxidant Levels in Different Clinical Staging and Histological Grading of Oral Squamous Cell Carcinoma: Noninvasive Technique in Dentistry

Analysis of Salivary Antioxidant Levels in Different Clinical Staging and Histological Grading of Oral Squamous Cell Carcinoma: Noninvasive Technique in Dentistry

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

Periodontal Disease and Nuclear and Oxidative DNA Damage

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