Salivary and serum antibodies in patients with Yersinia enterocolitica infection

Grönblad, Eva A.; Mãkelä, O.

doi:10.1016/0882-4010(86)90041-0

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Several recent studies have documented a rise in serum titér of Yersinia-specific antibody early in infection (8,9,15), primarily accounted for by immunoglobulin A (IgA) class antibodies, in particular the 11S or dimer form normally found in secretions (8). Since methods for detecting IgA in serum are not entirely reliable (15) and no criteria exist for ascribing significance to an increased IgA titer (4), the diagnostic applications of serum IgA levels are limited.…”

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confidence: 99%

Human coproantibody secretory immunoglobulin A response to Yersinia species

1988

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A semiquàntitative indirect immunofluorescence assay to detect coproantibody secretory IgA (SIgA) was established to investigate the human intestinal immune response to Yersinia species. This assay was based on microagglutination of SIgA in fecal specimens with the patient's homologous organism. Two populations of patients were defined, those who produced an agglutinating (2+) SIgA response and those who did not. A comparison between SIgA production and standard in vitro virulence-related characteristics of infecting organisms, including autoagglutination, calcium dependence, plasmid carriage, and absorption of Congo red, mouse virulence, and clinical presentation, was performed. A positive (2+) SIgA result was associated with acuté enteric illness (positive predictive value, 78.6%) and mouse virulence (positive predictive value, 85.7%). When patients With active inflammatory bowel disease were excluded, the positive predictive value of SIgA for mouse virulence and acute enteric disease became 100%. In addition to strains of Yersinia enterocolitica 4,0:3, strains generally characterized as nonpathogenic, including Yersiniafrederiksenii, were found to be associated with acute disease, mouse virulence, and stimulation of SIgA. The indirect immunofluorescence assay for detection of SIgA response appears to be a useful indicator of pathogenic strains of yersiniae recovered from énteric specimens. Yersinia enterocolitica is a causative agent of a variety of enteric disorders, including acute diarrhea, gastroenteritis, and pseudoappendicitis. Yersiniosis is generally self-limited, but Yersinia-related chronic diarrhea and postreactive syndromes (i.e., arthritis and erythema nodosum) have also been documented (8, 17, 18>. Other Yersinria species, Yersi

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Human coproantibody secretory immunoglobulin A response to Yersinia species

1988

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The development of oral fluid-based diagnostics and applications in veterinary medicine

Prickett

Zimmerman

2010

Anim. Health. Res. Rev.

139

110

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The purpose of this review was to discuss the history of the development and implementation of oral fluid diagnostics for infectious diseases of humans and domestic animals. The use of oral fluid for the assessment of health and diagnosis of disease in humans and animals has a surprisingly long history. As early as 1909, Pollaci and Ceraulo reported sensitive and specific agglutination of 'Micrococcus melitensis' (Brucella melitensis) by oral fluid from patients diagnosed with Malta Fever. A 1986 report of the detection of antibodies against human immunodeficiency virus (HIV) in oral fluid from patients with acquired immunodeficiency syndrome (AIDS) marked the start of a remarkably rapid series of developments in oral fluid-based assays. Cumulatively, the literature strongly supports implementation of oral fluid-based diagnostics in veterinary diagnostic medicine. Pathogen-specific IgA, IgM and IgG antibodies have all been demonstrated in oral fluid collected from diverse domestic animal species in response to infection. A variety of infectious agents, both local and systemic, are shed in oral fluid, including some of the most economically significant pathogens of production animals (e.g. foot-and-mouth disease virus, classical swine fever virus and porcine reproductive and respiratory syndrome virus) Ultimately, point-of-care rapid assays (i.e. cow-side, sow-side or pen-side tests) and access to real-time infectious disease data will revolutionize our delivery of health management services.

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