Salivary concentrations of IL-8 and IL-1ra after HIIT and MICT in young, healthy adults: A randomized exercise study

O’Neill, Carley; O’Rourke, Nicholas; Jeffrey, Michael; Green-Johnson, Julia M.; Dogra, Shilpa

doi:10.1016/j.cyto.2022.155965

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…Within this paper, we aim to report on salivary biomarkers analyzed with such a combined SERS-MD approach to characterize two important proteins found in saliva, which were not, to the best of our knowledge, described before. Currently detected predominantly using an expensive enzymatic immunoassay (i.e., ELISA test) [30], lysozyme (LYZ) and interleukin-8 (IL-8) have already been shown to be differentially expressed in several disease states of head and neck cancer or infections. IL-8 (1-3 ng/mL) is a non-structural protein secreted by neutrophils and macrophages, which plays an important role in the proliferation of angiogenesis and, in particular, its concentration dramatically increases in the presence of oropharyngeal squamous cell carcinoma (OSCC), which is one type of head and neck cancer [31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Label-Free SERS and MD Analysis of Biomarkers for Rapid Point-of-Care Sensors Detecting Head and Neck Cancer and Infections

Farnesi,

Rinaldi,

Liu

et al. 2023

Sensors

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For the progress of point-of-care medicine, where individual health status can be easily and quickly monitored using a handheld sensor, saliva serves as one of the best-suited body fluids thanks to its availability and abundance of physiological indicators. Salivary biomarkers, combined with rapid and highly sensitive detection tools, may pave the way to new real-time health monitoring and personalized preventative therapy branches using saliva as a target matrix. Saliva is increasing in importance in liquid biopsy, a non-invasive approach that helps physicians diagnose and characterize specific diseases in patients. Here, we propose a proof-of-concept study combining the unique specificity in biomolecular recognition provided by surface-enhanced Raman spectroscopy (SERS) in combination with molecular dynamics (MD) simulations, which give leave to explore the biomolecular absorption mechanism on nanoparticle surfaces, in order to verify the traceability of two validated salivary indicators, i.e., interleukin-8 (IL-8) and lysozyme (LYZ), implicated in oropharyngeal squamous cell carcinoma (OSCC) and oral infection. This strategy simultaneously assures the detection and interpretation of protein biomarkers in saliva, ultimately opening a new route for the evolution of fast and accurate point-of-care SERS-based sensors of interest in precision medicine diagnostics.

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Section: Introductionmentioning

confidence: 99%

Label-Free SERS and MD Analysis of Biomarkers for Rapid Point-of-Care Sensors Detecting Head and Neck Cancer and Infections

Farnesi,

Rinaldi,

Liu

et al. 2023

Sensors

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“…HIIT has also been indicated for various health conditions ranging from obesity, and type 2 diabetes mellitus (Motta et al, 2016;Martins et al, 2017), nonalcoholic fatty liver disease, inflammatory diseases (Winn et al, 2018;Castro-de-Paiva et al, 2022;O'Neill et al, 2022), systemic arterial hypertension (Moraes-Teixeira et al, 2010;de Oliveira et al, 2020), stroke (Gjellesvik et al, 2020), menopause (Pimenta et al, 2015;Jabbour & Iancu, 2020), mental illness (Korman et al, 2020) and cancer (Herranz-Gómez et al, 2022), among others.…”

Section: Introductionmentioning

confidence: 99%

High-Intensity Interval Training (Treadmill) Effects in Myokines and Endoplasmic Reticulum Stress of Calf Muscles in Obese Mice

et al. 2023

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Obesity is commonly associated with chronic tissue inflammation and skeletal muscle dysfunction. The study aimed to investigate the effects of High-Intensity Interval training (HIIT) on myokines and endoplasmic reticulum (ER) stress of dietinduced obese (DIO) mice. Three-month-old C57BL/6 male mice were fed a control (C) diet (n=20) or a high-fat (HF) diet (n=20) for 16 weeks. Then, half of the groups underwent HIIT (treadmill running) for an additional four weeks. HIIT increased calf muscles' contribution to BW (+24 %) and reduced weight gain in HF/HIIT than in HF (-120 %). Intramuscular fat accumulation was observed in HF and HF/ HIIT. Peak velocity was higher in HF/HIIT compared to HF (+26 %). Plasma insulin did not change, but glycemia was lower in HF/HIIT than in HF (-30 %). Fndc5 (+418 %) and Irisin (+72 %) were higher in HF/HIIT than in HF. Muscle Fgf21 was higher in HF/HIIT compared to HF (+30 %). In addition, NfKb (-53 %) and Tnfa (-63 %) were lower in HF/HIIT than in HF. However, Il1b (-86 %), Il6 (-48 %), Il7 (-76 %), and Il15 (-21 %) were lower in HF/HIIT than in HF. Finally, HIIT reduced ER stress in HF/HIIT compared to HF: Atf4, -61 %; Chop, -61 %; Gadd45, -95 %. In conclusion, HIIT leads to weight loss and avoids muscle depletion. HIIT improves blood glucose, Irisin-Fndc5, and peak velocity. In addition, HIIT mitigates muscle inflammation and ER stress.

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Short bouts of walking attenuates the response of IL-8 to prolonged sitting in healthy adults

et al. 2023

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Salivary concentrations of IL-8 and IL-1ra after HIIT and MICT in young, healthy adults: A randomized exercise study

Cited by 6 publications

References 45 publications

Label-Free SERS and MD Analysis of Biomarkers for Rapid Point-of-Care Sensors Detecting Head and Neck Cancer and Infections

Label-Free SERS and MD Analysis of Biomarkers for Rapid Point-of-Care Sensors Detecting Head and Neck Cancer and Infections

High-Intensity Interval Training (Treadmill) Effects in Myokines and Endoplasmic Reticulum Stress of Calf Muscles in Obese Mice

Short bouts of walking attenuates the response of IL-8 to prolonged sitting in healthy adults

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