Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional study

Larsson, Charlotte; Gullberg, Bo; Råstam, Lennart; Lindblad, Ulf

doi:10.1186/1472-6823-9-16

Cited by 147 publications

(120 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have also indicated that cortisol levels differ between men and women [8]- [11], [12]- [14]. In our study, there were noticed higher levels of salivary and serum cortisol values in the nurses working in the emergency department, compared to the nurses working in the pathology department.…”

Section: Discussionsupporting

confidence: 55%

Sex Differences in Salivary and Serum Cortisol Values Among Nurses and Correlation with Work Stress

2016

IJSR

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 55%

Sex Differences in Salivary and Serum Cortisol Values Among Nurses and Correlation with Work Stress

2016

IJSR

View full text Add to dashboard Cite

“…Also, in other studies (46,47), no correlation was found between human tissue HSD11B1 expression and age. Moreover, it is known that the hyperactivity of the HPA axis is reported mainly in the elderly people and there are no significant differences during adulthood (48,49). According to our findings, it seems that in severely obese patients without MetS, the downregulation of NR3C1a in the liver as well as the lower expression of HSD11B1 in the VAT might protect them from the development of metabolic consequences of their obesity.…”

Section: European Journal Of Endocrinologymentioning

confidence: 61%

Cortisol in tissue and systemic level as a contributing factor to the development of metabolic syndrome in severely obese patients

Constantinopoulos

Michalaki

Κοττόρου

et al. 2015

European Journal of Endocrinology

View full text Add to dashboard Cite

Context: Adrenal and extra-adrenal cortisol production may be involved in the development of metabolic syndrome (MetS). Objective: To investigate the activity of the hypothalamic-pituitary-adrenal (HPA) axis and the expression of HSD11B1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptors) a (NR3C1a) and b (NR3C1b) in the liver, subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) of severely obese patients with and without MetS. Methods: The study included 37 severely obese patients (BMI R40 kg/m 2 ), 19 with MetS (MetSC group) and 18 without (MetSK group), studied before and during bariatric surgery. Before the day of surgery, urinary free cortisol (UFC) and diurnal variation of serum and salivary cortisol were estimated. During surgery, biopsies of the liver, VAT and SAT were obtained. The expression of HSD11B1, NR3C1a and NR3C1b was evaluated by RT-PCR.Results: UFC and area under the curve for 24-h profiles of serum and salivary cortisol were lower in the MetSK group. In the MetSK group, mRNA levels of HSD11B1 in liver exhibited a negative correlation with liver NR3C1a (LNR3C1a) and VAT expression of HSD11B1 was lower than the MetSC group. Conclusions: We observed a downregulation of the NR3C1a expression and lower VAT mRNA levels of HSD11B1 in the MetSK group, indicating a lower selective tissue cortisol production and action that could protect these patients from the metabolic consequences of obesity. In the MetSK group, a lower activity of the HPA axis was also detected. Taken together, cortisol in tissue and systematic level might play a role in the development of MetS in severely obese patients.

show abstract

“…Two thirds of the population were younger than 50 years. The procedure is described in detail in previous publications [22]. The ten year follow-up is now ongoing and full data for the Skövde cohort has been collected.…”

Section: Study Populationsmentioning

confidence: 99%

Primary care screening for individuals with impaired glucose metabolism with focus on impaired glucose tolerance

Hellgren

Daka

Jansson

et al. 2015

Primary Care Diabetes

Self Cite

View full text Add to dashboard Cite

Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional study

Abstract: Background: Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population.

Cited by 147 publications

References 39 publications

Sex Differences in Salivary and Serum Cortisol Values Among Nurses and Correlation with Work Stress

Sex Differences in Salivary and Serum Cortisol Values Among Nurses and Correlation with Work Stress

Cortisol in tissue and systemic level as a contributing factor to the development of metabolic syndrome in severely obese patients

Primary care screening for individuals with impaired glucose metabolism with focus on impaired glucose tolerance

Contact Info

Product

Resources

About